اکتینین آلفا ۳

اکتینین آلفا ۳ (انگلیسی: Actinin alpha 3‎) یک پروتئین است که در انسان توسط ژن «ACTN3» کُدگذاری می‌شود.[1][2]

Actinin alpha 3
معین‌کننده‌ها
نام‌های دیگرalpha-actinin skeletal muscleAlpha-actinin skeletal muscle isoform 3actininalpha 3F-actin cross-linking proteinalpha-actinin-3ACTN3
شناسه‌های بیرونیGeneCards:
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

n/a

n/a

آنسامبل

n/a

n/a

یونی‌پروت

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (پروتئین)

n/a

n/a

موقعیت (UCSC)n/an/a
جستجوی PubMedn/an/a
ویکی‌داده
مشاهده/ویرایش Human

این پروتئین نوعی اکتین است که چندین نقش مهم ایفا می‌کند و بیان آن محدود به ماهیچه‌های اسکلتی است.

اهمیت ورزشی

به‌نظر می‌رسد که میان چندریختی «ACTN3 R577X» و عملکردِ ورزشکاران حرفه‌ای در پاورلیفتینگ و دو سرعت ارتباطی موجود باشد. این چندریختی ژنی با ریکاوری پس از ورزش و میزان آسیب‌دیدگی نیز مرتبط است؛[3] بدین نحو که در ژنوتیپ XX، احتمال آسیب دیدگی عضلات بیشتر است و مدت زمان بیشتری لازم است تا ماهیچه‌ها بهبود یابند.[3]

منابع
  1. "Entrez Gene: ACTN3 actinin, alpha 3".
  2. Beggs AH, Byers TJ, Knoll JH, Boyce FM, Bruns GA, Kunkel LM (May 1992). "Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11". The Journal of Biological Chemistry. 267 (13): 9281–8. PMID 1339456.
  3. Pickering C, Kiely J (2017). "ACTN3: More than Just a Gene for Speed". Frontiers in Physiology. 8: 1080. doi:10.3389/fphys.2017.01080. PMC 5741991. PMID 29326606.

برای مطالعهٔ بیشتر
  • MacArthur DG, North KN (July 2004). "A gene for speed? The evolution and function of alpha-actinin-3". BioEssays. 26 (7): 786–95. doi:10.1002/bies.20061. PMID 15221860.
  • Beggs AH, Byers TJ, Knoll JH, Boyce FM, Bruns GA, Kunkel LM (May 1992). "Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11". The Journal of Biological Chemistry. 267 (13): 9281–8. PMID 1339456.
  • Yürüker B, Niggli V (February 1992). "Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network". Journal of Cell Science. 101. 101 ( Pt 2): 403–14. PMID 1629252.
  • Pavalko FM, LaRoche SM (October 1993). "Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". Journal of Immunology. 151 (7): 3795–807. PMID 8104223.
  • Chan Y, Tong HQ, Beggs AH, Kunkel LM (July 1998). "Human skeletal muscle-specific alpha-actinin-2 and -3 isoforms form homodimers and heterodimers in vitro and in vivo". Biochemical and Biophysical Research Communications. 248 (1): 134–9. doi:10.1006/bbrc.1998.8920. PMID 9675099.
  • North KN, Yang N, Wattanasirichaigoon D, Mills M, Easteal S, Beggs AH (April 1999). "A common nonsense mutation results in alpha-actinin-3 deficiency in the general population". Nature Genetics. 21 (4): 353–4. doi:10.1038/7675. PMID 10192379.
  • Nikolopoulos SN, Spengler BA, Kisselbach K, Evans AE, Biedler JL, Ross RA (January 2000). "The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells". Oncogene. 19 (3): 380–6. doi:10.1038/sj.onc.1203310. PMID 10656685.
  • Takada F, Vander Woude DL, Tong HQ, Thompson TG, Watkins SC, Kunkel LM, Beggs AH (February 2001). "Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines". Proceedings of the National Academy of Sciences of the United States of America. 98 (4): 1595–600. doi:10.1073/pnas.041609698. PMC 29302. PMID 11171996.
  • Bang ML, Mudry RE, McElhinny AS, Trombitás K, Geach AJ, Yamasaki R, Sorimachi H, Granzier H, Gregorio CC, Labeit S (April 2001). "Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies". The Journal of Cell Biology. 153 (2): 413–27. doi:10.1083/jcb.153.2.413. PMC 2169455. PMID 11309420.
  • Mills M, Yang N, Weinberger R, Vander Woude DL, Beggs AH, Easteal S, North K (June 2001). "Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy". Human Molecular Genetics. 10 (13): 1335–46. doi:10.1093/hmg/10.13.1335. PMID 11440986.
  • Burgueño J, Blake DJ, Benson MA, Tinsley CL, Esapa CT, Canela EI, Penela P, Mallol J, Mayor F, Lluis C, Franco R, Ciruela F (September 2003). "The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin". The Journal of Biological Chemistry. 278 (39): 37545–52. doi:10.1074/jbc.M302809200. PMID 12837758.
  • Clarkson PM, Devaney JM, Gordish-Dressman H, Thompson PD, Hubal MJ, Urso M, Price TB, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Seip RL, Hoffman EP (July 2005). "ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women". Journal of Applied Physiology. 99 (1): 154–63. doi:10.1152/japplphysiol.01139.2004. PMID 15718405.
  • Franzot G, Sjöblom B, Gautel M, Djinović Carugo K (April 2005). "The crystal structure of the actin binding domain from alpha-actinin in its closed conformation: structural insight into phospholipid regulation of alpha-actinin". Journal of Molecular Biology. 348 (1): 151–65. doi:10.1016/j.jmb.2005.01.002. PMID 15808860.
  • Clarkson PM, Hoffman EP, Zambraski E, Gordish-Dressman H, Kearns A, Hubal M, Harmon B, Devaney JM (August 2005). "ACTN3 and MLCK genotype associations with exertional muscle damage". Journal of Applied Physiology. 99 (2): 564–9. doi:10.1152/japplphysiol.00130.2005. PMID 15817725.
  • Asanuma K, Kim K, Oh J, Giardino L, Chabanis S, Faul C, Reiser J, Mundel P (May 2005). "Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner". The Journal of Clinical Investigation. 115 (5): 1188–98. doi:10.1172/JCI23371. PMC 1070637. PMID 15841212.
  • Niemi AK, Majamaa K (August 2005). "Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes". European Journal of Human Genetics. 13 (8): 965–9. doi:10.1038/sj.ejhg.5201438. PMID 15886711.
  • Triplett JW, Pavalko FM (November 2006). "Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis". American Journal of Physiology. Cell Physiology. 291 (5): C909–21. doi:10.1152/ajpcell.00113.2006. PMID 16807302.

پیوند به بیرون
در ویکی‌انبار پرونده‌هایی دربارهٔ اکتینین آلفا ۳ موجود است.
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