HSPA6

HSPA6
ساختارهای موجود
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3FE1
معین‌کننده‌ها
نام‌های دیگر	HSPA6, HSP70B', heat shock protein family A (Hsp70) member 6
شناسه‌های بیرونی	OMIM: 140555 HomoloGene: 105648 GeneCards: HSPA6
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• enzyme binding; • unfolded protein binding; • nucleotide binding; • GO:0001948 پیوند پروتئینی; • ATP binding; • heat shock protein binding; • ATPase activity; • protein folding chaperone; • misfolded protein binding;
ترکیبات سلولی	• سیتوپلاسم; • میانک; • COP9 signalosome; • سیتوزول; • extracellular exosome; • blood microparticle; • extracellular region; • secretory granule lumen; • ficolin-1-rich granule lumen; • هسته یاخته; • protein-containing complex;
فرایند زیستی	• cellular heat acclimation; • response to unfolded protein; • cellular response to heat; • protein refolding; • neutrophil degranulation; • cellular response to unfolded protein; • chaperone cofactor-dependent protein refolding;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3310
	n/a
	ENSG00000173110
	n/a
	P17066
	n/a
	NM_002155
	n/a
	NP_002146
	n/a
	ویکی‌داده
مشاهده/ویرایش Human

پروتئین ۶ گرماشوک ۷۰ کیلو دالتونی (انگلیسی: Heat shock 70 kDa protein 6‎) یک پروتئین است که در انسان توسط ژن «HSPA6» کُدگذاری می‌شود.[2][3]

منابع

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Leung TK, Hall C, Rajendran M, Spurr NK, Lim L (Mar 1992). "The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1". Genomics. 12 (1): 74–9. doi:10.1016/0888-7543(92)90409-L. PMID 1346391.
"Entrez Gene: HSPA6 heat shock 70kDa protein 6 (HSP70B')".

مشارکت‌کنندگان ویکی‌پدیا. «HSPA6». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۱ آوریل ۲۰۲۰.

برای مطالعهٔ بیشتر

Leung TK, Rajendran MY, Monfries C, et al. (1990). "The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B') and isolation of its cDNA and genomic DNA". Biochem. J. 267 (1): 125–32. doi:10.1042/bj2670125. PMC 1131254. PMID 2327978.
Schiller P, Amin J, Ananthan J, et al. (1988). "Cis-acting elements involved in the regulated expression of a human HSP70 gene". J. Mol. Biol. 203 (1): 97–105. doi:10.1016/0022-2836(88)90094-0. PMID 3184191.
Rensing SA, Maier UG (1994). "Phylogenetic analysis of the stress-70 protein family". J. Mol. Evol. 39 (1): 80–6. doi:10.1007/BF00178252. PMID 7545947.
Furlini G, Vignoli M, Re MC, et al. (1994). "Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein". J. Gen. Virol. 75 (1): 193–9. doi:10.1099/0022-1317-75-1-193. PMID 7906708.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Mercier PA, Winegarden NA, Westwood JT (1999). "Human heat shock factor 1 is predominantly a nuclear protein before and after heat stress". J. Cell Sci. 112. ( Pt 16): 2765–74. PMID 10413683.
O'Keeffe B, Fong Y, Chen D, et al. (2000). "Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription". J. Biol. Chem. 275 (1): 279–87. doi:10.1074/jbc.275.1.279. PMID 10617616.
Agostini I, Popov S, Li J, et al. (2000). "Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex". Exp. Cell Res. 259 (2): 398–403. doi:10.1006/excr.2000.4992. PMID 10964507.
Gurer C, Cimarelli A, Luban J (2002). "Specific incorporation of heat shock protein 70 family members into primate lentiviral virions". J. Virol. 76 (9): 4666–70. doi:10.1128/JVI.76.9.4666-4670.2002. PMC 155079. PMID 11932435.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lim MC, Brooke SM, Sapolsky RM (2003). "gp120 neurotoxicity fails to induce heat shock defenses, while the over expression of hsp70 protects against gp120". Brain Res. Bull. 61 (2): 183–8. doi:10.1016/S0361-9230(03)00113-8. PMID 12832005.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

پیوند به بیرون

HSPA6 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

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[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1346391-2] Leung TK, Hall C, Rajendran M, Spurr NK, Lim L (Mar 1992). "The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1". Genomics. 12 (1): 74–9. doi:10.1016/0888-7543(92)90409-L. PMID 1346391.

[entrez-3] "Entrez Gene: HSPA6 heat shock 70kDa protein 6 (HSP70B')".