اینتگرین بتا-۵

اینتگرین بتا-۵ (انگلیسی: Integrin beta-5‎) یک پروتئین است که در انسان توسط ژن «ITGB5» کُدگذاری می‌شود.[4][5]

ITGB5
معین‌کننده‌ها
نام‌های دیگر	ITGB5, Integrin, beta 5, integrin subunit beta 5
شناسه‌های بیرونی	OMIM: 147561 MGI: 96614 HomoloGene: 20511 GeneCards: ITGB5
Gene location (Mouse) Chr. Chromosome 16 (mouse)[1] Band 16|16 B3 Start 33,829,665 bp[1] End 33,949,338 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • virus receptor activity • GO:0001948 پیوند پروتئینی • integrin binding • signaling receptor activity ترکیبات سلولی • integral component of membrane • membrane • focal adhesion • receptor complex • پوسته یاخته • cell surface • integrin complex • phagocytic vesicle • integrin alphav-beta5 complex • extracellular exosome فرایند زیستی • کشش ماهیچه • endodermal cell differentiation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • extracellular matrix organization • epithelial cell-cell adhesion • stress fiber assembly • cell adhesion • integrin-mediated signaling pathway • ورود ویروس • cell-matrix adhesion • GO:0022415 viral process • transforming growth factor beta receptor signaling pathway • کوچ یاخته • cell adhesion mediated by integrin Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	3693	16419
آنسامبل	ENSG00000082781	ENSMUSG00000022817
یونی‌پروت	P18084	O70309
RefSeq (mRNA)	NM_002213، XM_005247436، XM_017006353، XM_017006354، XM_017006355، NM_001354764، NM_001354765، NM_001354766 XM_006713630، NM_002213، XM_005247436، XM_017006353، XM_017006354، XM_017006355، NM_001354764، NM_001354765، NM_001354766	NM_010580، XM_030248983 NM_001145884، NM_010580، XM_030248983
RefSeq (پروتئین)	XP_005247493، XP_006713693، XP_016861842، XP_016861843، XP_016861844، NP_001341693، NP_001341694، NP_001341695 NP_002204، XP_005247493، XP_006713693، XP_016861842، XP_016861843، XP_016861844، NP_001341693، NP_001341694، NP_001341695	NP_034710، XP_030104843 NP_001139356، NP_034710، XP_030104843
موقعیت (UCSC)	n/a	Chr : 33.83 – 33.95 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

افزایش سطح این پروتئین در بیمارانی که از «پوکی استخوان نوع ۲» (اتوزومال غالب) رنج می‌برند، دیده شده‌است.[6]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000022817 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. PMID 2211615.
5. "Entrez Gene: ITGB5 integrin, beta 5".
6. Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology". Lab Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069.

• مشارکت‌کنندگان ویکی‌پدیا. «Integrin, beta 5». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۸ ژانویه ۲۰۱۸.

بیشتر بخوانید

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• Pasqualini R, Bodorova J, Ye S, Hemler ME (1993). "A study of the structure, function and distribution of beta 5 integrins using novel anti-beta 5 monoclonal antibodies". J. Cell Sci. 105 (1): 101–11. PMID 7689573.
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