تناسین ایکس

تناسین ایکس (انگلیسی: Tenascin X‎) یا «پروتئین شبه هگزابراکیون» یک گلیکوپروتئین است که در انسان توسط ژن «TNXB» کُد می‌شود و در بافت‌های همبند نظیر پوست، مفاصل و عضلات یافت می‌شود.[4]

TNXB
ساختارهای موجود PDB Human UniProt search: PDBe RCSB List of PDB id codes 2CUH, 2CUI, 2CUM
معین‌کننده‌ها
نام‌های دیگر	TNXB, EDS3, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS, tenascin XB, EDSCLL, EDSCLL1
شناسه‌های بیرونی	OMIM: 600985 MGI: 1932137 HomoloGene: 49589 GeneCards: TNXB
Gene location (Mouse) Chr. Chromosome 17 (mouse)[1] Band 17 B1|17 18.24 cM Start 34,660,457 bp[1] End 34,719,815 bp[1]
هستی‌شناسی ژن عملکرد ملکولی • integrin binding • GO:0001948 پیوند پروتئینی • heparin binding • extracellular matrix structural constituent • collagen fibril binding ترکیبات سلولی • GO:0005578 بافت‌مانه برون‌یاخته‌ای • intracellular anatomical structure • fibrillar collagen trimer • extracellular exosome • extracellular space • extracellular region • collagen-containing extracellular matrix فرایند زیستی • collagen fibril organization • collagen metabolic process • extracellular matrix organization • cell adhesion • elastic fiber assembly • actin cytoskeleton organization Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	7148	81877
آنسامبل	ENSG00000236236 ENSG00000236221 ENSG00000229353 ENSG00000229341 ENSG00000233323 ENSG00000231608 ENSG00000206258 ENSG00000168477	ENSMUSG00000033327
یونی‌پروت	P22105	n/a
RefSeq (mRNA)	NM_019105، NM_001365276 NM_032470، NM_019105، NM_001365276	XM_006525185، XM_006525186، XM_006525187، XM_006525188، XM_006525189، XM_006525191 NM_031176، XM_006525185، XM_006525186، XM_006525187، XM_006525188، XM_006525189، XM_006525191
RefSeq (پروتئین)	NP_115859، NP_001352205 NP_061978، NP_115859، NP_001352205	n/a
موقعیت (UCSC)	n/a	Chr : 34.66 – 34.72 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

این پروتئین خاصیت ضدچسبندگی دارد (بر خلاف فیبرونکتین) و احتمالاً در جریانِ فرایند بهبود زخم‌ها، در بلوغِ ماتریکس برون‌یاخته‌ای نقش دارد.[5]

فقدان تناسین ایکس موجب بروز یکی از انواع نشانگان اهلرز-دنلوس می‌شود که در آن تراکم کلاژن کاهش یافته و رشته‌های اِلاستیکی تکه‌تکه می‌شوند.[6]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000033327 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Tee MK, Thomson AA, Bristow J, Miller WL (July 1995). "Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X". Genomics. 28 (2): 171–8. doi:10.1006/geno.1995.1128. PMID 8530023.
5. "Entrez Gene: tenascin XB".
6. Zweers, MC; Schalkwijk, J; Van Kuppevelt, TH; Van Vlijmen-Willems, IM; Bergers, M; Lethias, C; Lamme, EN (2005). "Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components". Cell and Tissue Research. 319 (2): 279–87. doi:10.1007/s00441-004-1011-6. PMID 15558324.

• مشارکت‌کنندگان ویکی‌پدیا. «Tenascin X». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ دسامبر ۲۰۱۷.

بیشتر بخوانید

• Goepel C (2008). "Differential elastin and tenascin immunolabeling in the uterosacral ligaments in postmenopausal women with and without pelvic organ prolapse". Acta Histochem. 110 (3): 204–9. doi:10.1016/j.acthis.2007.10.014. PMID 18155129.
• Yuan Y, Nymoen DA, Stavnes HT, et al. (2009). "Tenascin-X is a novel diagnostic marker of malignant mesothelioma". Am. J. Surg. Pathol. 33 (11): 1673–82. doi:10.1097/PAS.0b013e3181b6bde3. PMC 2783994. PMID 19738457.
• Egging D, van Vlijmen-Willems I, van Tongeren T, et al. (2007). "Wound healing in tenascin-X deficient mice suggests that tenascin-X is involved in matrix maturation rather than matrix deposition". Connect. Tissue Res. 48 (2): 93–8. doi:10.1080/03008200601166160. PMID 17453911.
• Egging DF, van Vlijmen-Willems I, Choi J, et al. (2008). "Analysis of obstetric complications and uterine connective tissue in tenascin-X-deficient humans and mice". Cell Tissue Res. 332 (3): 523–32. doi:10.1007/s00441-008-0591-y. PMC 2386751. PMID 18335242.
• Kato A, Endo T, Abiko S, et al. (2008). "Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions". Exp. Cell Res. 314 (14): 2661–73. doi:10.1016/j.yexcr.2008.05.019. PMID 18588874.
• Bristow J, Carey W, Egging D, Schalkwijk J (2005). "Tenascin-X, collagen, elastin, and the Ehlers-Danlos syndrome". American Journal of Medical Genetics. 139C (1): 24–30. doi:10.1002/ajmg.c.30071. PMID 16278880.
• Fellay J, Ge D, Shianna KV, et al. (2009). McCarthy MI, ed. "Common genetic variation and the control of HIV-1 in humans". PLoS Genet. 5 (12): e1000791. doi:10.1371/journal.pgen.1000791. PMC 2791220. PMID 20041166.
• Kamatani Y, Matsuda K, Ohishi T, et al. (2008). "Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population". J. Hum. Genet. 53 (1): 64–73. doi:10.1007/s10038-007-0219-1. PMID 18058064.
• Valdes AM, Thomson G (2009). "Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1". Diabetes Obes Metab. 11. Suppl 1: 46–52. doi:10.1111/j.1463-1326.2008.01002.x. PMC 2755069. PMID 19143814.
• Yu CY (1998). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631.
• Endo T, Ariga H, Matsumoto K (2009). "Truncated form of tenascin-X, XB-S, interacts with mitotic motor kinesin Eg5". Mol. Cell. Biochem. 320 (1–2): 53–66. doi:10.1007/s11010-008-9898-y. PMID 18679583.
• Sovio U, Bennett AJ, Millwood IY, et al. (2009). Gibson G, ed. "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966". PLoS Genet. 5 (3): e1000409. doi:10.1371/journal.pgen.1000409. PMC 2646138. PMID 19266077.
• Araújo VC, Furuse C, Cury PR, et al. (2008). "Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma". Appl. Immunohistochem. Mol. Morphol. 16 (1): 48–53. doi:10.1097/PAI.0b013e31802eff1c. PMID 18091320.
• Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951.
• Barcellos LF, May SL, Ramsay PP, et al. (2009). Roopenian DC, ed. "High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions". PLoS Genet. 5 (10): e1000696. doi:10.1371/journal.pgen.1000696. PMC 2758598. PMID 19851445.
• McKinnon E, Morahan G, Nolan D, et al. (2009). "Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach". Diabetes Obes Metab. 11 (Suppl 1): 92–100. doi:10.1111/j.1463-1326.2008.01009.x. PMC 2755510. PMID 19143821.
• Chapuis J, Hot D, Hansmannel F, et al. (2009). "Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease". Mol. Psychiatry. 14 (11): 1004–16. doi:10.1038/mp.2009.10. PMC 2860783. PMID 19204726.
• Vignal C, Bansal AT, Balding DJ, et al. (2009). "Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci". Arthritis Rheum. 60 (1): 53–62. doi:10.1002/art.24138. PMID 19116923.
• Buysschaert ID, Grulois V, Eloy P, et al. (2010). "Genetic evidence for a role of IL33 in nasal polyposis". Allergy. 65 (5): 616–22. doi:10.1111/j.1398-9995.2009.02227.x. PMID 19860791.
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