کربوکسیل‌استراز ۲

کربوکسیل‌استراز ۲ (به انگلیسی: Carboxylesterase 2) یک پروتئین است که در انسان توسط ژن «CES2» کُدگذاری می‌شود.[3][4][5] این پروتئین عضوی از ابرخانواده هیدرولاز آلفا/بتا است.[6]

CES2
معین‌کننده‌ها
نام‌های دیگر	CES2, CE-2, CES2A1, PCE-2, iCE, Carboxylesterase 2, CES-2
شناسه‌های بیرونی	OMIM: 605278 MGI: 3648740 HomoloGene: 128645 GeneCards: CES2
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • methylumbelliferyl-acetate deacetylase activity • hydrolase activity • GO:0004091 carboxylic ester hydrolase activity • methyl indole-3-acetate esterase activity ترکیبات سلولی • endoplasmic reticulum lumen • شبکه آندوپلاسمی • extracellular space فرایند زیستی • xenobiotic metabolic process • فروگشت • prostaglandin metabolic process Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	8824	436059
آنسامبل	ENSG00000172831	ENSMUSG00000091813
یونی‌پروت	O00748	F6Z9B9
RefSeq (mRNA)	NM_198061، NM_001365405، NM_001365406، NM_001365407، NM_001365408 NM_003869، NM_198061، NM_001365405، NM_001365406، NM_001365407، NM_001365408	NM_001272045
RefSeq (پروتئین)	NP_932327، NP_001352334، NP_001352335، NP_001352336، NP_001352337 NP_003860، NP_932327، NP_001352334، NP_001352335، NP_001352336، NP_001352337	NP_001258974
موقعیت (UCSC)	n/a	n/a
جستجوی PubMed	[1]	[2]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

این آنزیم متعلق به خانواده‌ای از آنزیم‌هاست که سبب هیدرولیز داروهای حاوی پیوندهای استری و آمیدی همچون کوکائین و هروئین می‌گردند. این خانوادهٔ آنزیمی می‌توانند سبب تجزیهٔ اسید چرب با زنجیرهٔ بلند و تیواسترها نیز بشوند. عملکرد خاص این آنزیم هنوز به‌خوبی مشخص نیست، اما احتمال دارد که کربوکسیل‌استرازها در سوخت‌وساز چربی و در ساختمان سد خونی مغزی نقش داشته باشند. دو گونه پیرایش دگرسان برای برای ژن «CES2» کشف شده‌است که یک پروتئین واحد را می‌سازند.[5]

نقشهٔ مسیر تعاملی

بر روی نام ژن‌ها، پروتئین‌ها و متابولیت‌ها کلیک کنید تا به مقالهٔ اختصاصی هر یک از آنها هدایت شوید.[§ 1] [[File: [[<div style="display:block; width:58px; height:0px; overflow:hidden; position:relative; right:174.0px; top:75px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:53px; height:0px; overflow:hidden; position:relative; right:308.0px; top:87px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:53px; height:0px; overflow:hidden; position:relative; right:308.0px; top:67px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:51px; height:0px; overflow:hidden; position:relative; right:72.0px; top:120px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:59px; height:0px; overflow:hidden; position:relative; right:54.0px; top:178px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; 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width:46px; height:0px; overflow:hidden; position:relative; right:344.0px; top:170px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:39px; height:0px; overflow:hidden; position:relative; right:245.0px; top:352px; background:transparent; border-top:3px green solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:350.0px; top:238px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:440.0px; top:302px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:544.0px; top:301px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:321.0px; top:400px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; 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width:80px; height:0px; overflow:hidden; position:relative; right:437.0px; top:816px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:80px; height:0px; overflow:hidden; position:relative; right:389.0px; top:863px; background:transparent; border-top:3px green solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:487.5px; top:842px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:386.5px; top:890px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:430.5px; top:890px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:386.5px; top:910px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:430.5px; top:910px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:180.5px; top:966px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:224.5px; top:966px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:180.5px; top:946px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:44px; height:0px; overflow:hidden; position:relative; right:224.5px; top:946px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:37px; height:12px; overflow:hidden; position:relative; right:436.5px; top:100px; background:transparent; border:4px black solid"></div>]] |{{{اندازه پایه}}}px|alt=]] فعالیت (5-FU) فلوروراسیل؛ ویرایش این نقشهٔ مسیر تعاملی در ویکی‌مسیر قابل ویرایش است: "FluoropyrimidineActivity_WP1601".

بر روی نام ژن‌ها، پروتئین‌ها و متابولیت‌ها کلیک کنید تا به مقالهٔ اختصاصی هر یک از آنها هدایت شوید. [§ 1] [[File: [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:494.74789915966403px; top:463.949579831933px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:374.3333333333333px; top:354.333333333333px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:365.6666666666667px; top:312px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:415.10084033613447px; top:130px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:49.3333333333333px; height:0px; overflow:hidden; position:relative; right:135.66666666666555px; top:294.422969187675px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; 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height:0px; overflow:hidden; position:relative; right:251.0px; top:484px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:531.3837535014006px; top:500.019607843137px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:88.43417366946755px; top:583.6162464986px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:88.43417366946755px; top:603.6162464986px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:326.6666666666667px; top:721.666666666667px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:216.0px; top:707.333333333333px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:216.0px; top:727.333333333333px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:352.4341736694678px; top:571.434173669467px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:352.4341736694678px; top:591.434173669467px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:352.4341736694678px; top:611.434173669467px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:49.2408963585433px; height:0px; overflow:hidden; position:relative; right:479.12044817927165px; top:721.487394957983px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:55.0728291316524px; height:0px; overflow:hidden; position:relative; right:406.06162464986005px; top:721.487394957983px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:48.3865546218487px; height:0px; overflow:hidden; position:relative; right:177.45378151260496px; top:130.666666666667px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:52.1176470588235px; height:0px; overflow:hidden; position:relative; right:247.25210084033603px; top:130.666666666667px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:46.3445378151259px; height:0px; overflow:hidden; position:relative; right:341.2605042016808px; top:130.666666666667px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:551.1008403361344px; top:594.717086834733px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:49.8263305322132px; height:0px; overflow:hidden; position:relative; right:483.7871148459377px; top:188.3837535014px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:60px; height:0px; overflow:hidden; position:relative; right:414.3333333333333px; top:409.333333333333px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:53.6554621848737px; height:0px; overflow:hidden; position:relative; right:410.6302521008398px; top:186.176470588235px; background:transparent; border-top:3px blue solid"></div>]] [[<div style="display:block; width:53px; height:12px; overflow:hidden; position:relative; right:374.3333333333333px; top:337.333333333333px; background:transparent; border:4px black solid"></div>]] |{{{اندازه پایه}}}px|alt=]] مسیر ایرینوتکان؛ ویرایش نقشهٔ مسیر تعاملی در ویکی‌مسیر قابل ویرایش است: "IrinotecanPathway_WP46359".

منابع

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF (Jun 1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". J Biol Chem. 272 (23): 14769–75. doi:10.1074/jbc.272.23.14769. PMID 9169443.
4. Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G (Jun 1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochem Biophys Res Commun. 233 (1): 117–20. doi:10.1006/bbrc.1997.6413. PMID 9144407.
5. "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)".
6. Imai T (Jun 2006). "Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120.

• مشارکت‌کنندگان ویکی‌پدیا. «Carboxylesterase 2». در دانشنامهٔ ویکی‌پدیای انگلیسی.

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