BAD
آگونیست مرگ سلول مرتبط با لنفوم ۲ لنفوسیت‌های بی (انگلیسی: Bcl-2-associated death promoter)[1] یک پروتئین است که در انسان توسط ژن «BAD» کُدگذاری می‌شود.
| BCL2 associated agonist of cell death | |||||||||||||||
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| معین‌کننده‌ها | |||||||||||||||
| نام‌های دیگر | BCL2-binding component 6BCL2-antagonist of cell death proteinbcl-2-binding component 6BCL2-binding proteinbcl-XL/Bcl-2-associated death promoterbcl2-associated agonist of cell deathbcl2 antagonist of cell deathBADbcl-2-like protein 8BCL-X/BCL-2 binding proteinbcl2-L-8bcl-associated death protein | ||||||||||||||
| شناسه‌های بیرونی | GeneCards: | ||||||||||||||
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| گونه‌ها | انسان | موش | |||||||||||||
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| موقعیت (UCSC) | n/a | n/a | |||||||||||||
| جستجوی PubMed | n/a | n/a | |||||||||||||
| ویکی‌داده | |||||||||||||||
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| Pro-apoptotic Bcl-2 protein, BAD | |||||||||
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 کمپلکس ترکیبی مولکول bcl-xl با پپتیدی از پروتئینِ BAD | |||||||||
| شناسه‌ها | |||||||||
| نماد | Bcl-2_BAD | ||||||||
| پی‌فم | PF10514 | ||||||||
| اینترپرو | IPR018868 | ||||||||
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این پروتئین القاکنندهٔ آپوپتوز سلولی و عضوی از خانوادهٔ BH3 (از زیرگروه‌های خانواده Bcl-2) است[2] با این تفاوت که بر خلاف بیشتر اعضای این خانواده، فاقد دومِـین کربوکسیل تراغشایی در لایهٔ خارجی میتوکندری و هسته سلول است.[3]
منابع
- https://www.ncbi.nlm.nih.gov/gene/572#gene-expression
- Adachi M, Imai K (2002). "The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2". Cell Death Differ. 9 (11): 1240–7. doi:10.1038/sj.cdd.4401097. PMID 12404123.
- Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11". Mol. Endocrinol. 11 (12): 1858–67. doi:10.1210/me.11.12.1858. PMID 9369453.
- مشارکت‌کنندگان ویکی‌پدیا. «Bcl-2-associated death promoter». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ اکتبر ۲۰۲۰.
برای مطالعهٔ بیشتر
- Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M (2004). "HIV/SIV escape from immune surveillance: focus on Nef". Curr. HIV Res. 2 (2): 141–51. doi:10.2174/1570162043484924. PMID 15078178.
- Jiang P, Du W, Wu M (2007). "p53 and Bad: remote strangers become close friends". Cell Res. 17 (4): 283–5. doi:10.1038/cr.2007.19. PMID 17404594.
- Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ (1995). "Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death". Cell. 80 (2): 285–91. doi:10.1016/0092-8674(95)90411-5. PMID 7834748. S2CID 10343291.
- Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ (1996). "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)". Cell. 87 (4): 619–28. doi:10.1016/S0092-8674(00)81382-3. PMID 8929531. S2CID 860908.
- Wang HG, Rapp UR, Reed JC (1996). "Bcl-2 targets the protein kinase Raf-1 to mitochondria". Cell. 87 (4): 629–38. doi:10.1016/S0092-8674(00)81383-5. PMID 8929532. S2CID 16559750.
- Inohara N, Ding L, Chen S, Núñez G (1997). "harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". EMBO J. 16 (7): 1686–94. doi:10.1093/emboj/16.7.1686. PMC 1169772. PMID 9130713.
- Zha J, Harada H, Osipov K, Jockel J, Waksman G, Korsmeyer SJ (1997). "BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity". J. Biol. Chem. 272 (39): 24101–4. doi:10.1074/jbc.272.39.24101. PMID 9305851.
- Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11". Mol. Endocrinol. 11 (12): 1858–67. doi:10.1210/me.11.12.1858. PMID 9369453.
- del Peso L, González-García M, Page C, Herrera R, Nuñez G (1997). "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt". Science. 278 (5338): 687–9. Bibcode:1997Sci...278..687D. doi:10.1126/science.278.5338.687. PMID 9381178.
- Ottilie S, Diaz JL, Horne W, Chang J, Wang Y, Wilson G, Chang S, Weeks S, Fritz LC, Oltersdorf T (1997). "Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins". J. Biol. Chem. 272 (49): 30866–72. doi:10.1074/jbc.272.49.30866. PMID 9388232.
- Huang DC, Adams JM, Cory S (1998). "The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4". EMBO J. 17 (4): 1029–39. doi:10.1093/emboj/17.4.1029. PMC 1170452. PMID 9463381.
- Blume-Jensen P, Janknecht R, Hunter T (1998). "The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136". Curr. Biol. 8 (13): 779–82. doi:10.1016/S0960-9822(98)70302-1. PMID 9651683. S2CID 15596347.
- Strobel T, Tai YT, Korsmeyer S, Cannistra SA (1998). "BAD partly reverses paclitaxel resistance in human ovarian cancer cells". Oncogene. 17 (19): 2419–27. doi:10.1038/sj.onc.1202180. PMID 9824152.
- Song Q, Kuang Y, Dixit VM, Vincenz C (1999). "Boo, a novel negative regulator of cell death, interacts with Apaf-1". EMBO J. 18 (1): 167–78. doi:10.1093/emboj/18.1.167. PMC 1171112. PMID 9878060.
- Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G (1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3". Cancer Res. 59 (3): 533–7. PMID 9973195.
- Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC (1999). "Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD". Science. 284 (5412): 339–43. Bibcode:1999Sci...284..339W. doi:10.1126/science.284.5412.339. PMID 10195903.
- Holmgreen SP, Huang DC, Adams JM, Cory S (1999). "Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members". Cell Death Differ. 6 (6): 525–32. doi:10.1038/sj.cdd.4400519. PMID 10381646.
- Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B (1999). "alpha-Synuclein shares physical and functional homology with 14-3-3 proteins". J. Neurosci. 19 (14): 5782–91. doi:10.1523/JNEUROSCI.19-14-05782.1999. PMC 6783081 Check
|pmc=value (help). PMID 10407019. - Scheid MP, Schubert KM, Duronio V (1999). "Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase". J. Biol. Chem. 274 (43): 31108–13. doi:10.1074/jbc.274.43.31108. PMID 10521512.
- Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME (1999). "Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms". Science. 286 (5443): 1358–62. doi:10.1126/science.286.5443.1358. PMID 10558990.
پیوند به بیرون
- bcl-Associated Death Protein در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
- مکان ژنوم BAD انسانی و صفحهٔ جزئیات ژنی BAD در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
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