DCPS

DCPS با نامِ کاملِ «Scavenger mRNA-decapping enzyme DcpS» یک پروتئین است که در انسان توسط ژن «DCPS» کد می‌شود.[4][5][6]

DCPS
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 1ST0, 1ST4, 1XML, 1XMM, 3BL7, 3BL9, 3BLA, 4QDE, 4QDV, 4QEB
معین‌کننده‌ها
نام‌های دیگر	DCPS, DCS1, HINT-5, HINT5, HSL1, ARS, HSPC015, decapping enzyme, scavenger
شناسه‌های بیرونی	OMIM: 610534 MGI: 1916555 HomoloGene: 32202 GeneCards: DCPS
Gene location (Mouse) Chr. Chromosome 9 (mouse)[1] Band 9|9 A4 Start 35,124,408 bp[1] End 35,176,061 bp[1]
هستی‌شناسی ژن عملکرد ملکولی • m7G(5')pppN diphosphatase activity • GO:0001948 پیوند پروتئینی • hydrolase activity • RNA 7-methylguanosine cap binding • exoribonuclease activity ترکیبات سلولی • سیتوپلاسم • میتوکندری • هسته یاخته • نوکلئوپلاسم • P-body • سیتوزول فرایند زیستی • mRNA cis splicing, via spliceosome • negative regulation of programmed cell death • mRNA processing • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • cellular response to menadione • پیرایش آران‌ای • exonucleolytic catabolism of deadenylated mRNA • RNA phosphodiester bond hydrolysis, exonucleolytic • deadenylation-dependent decapping of nuclear-transcribed mRNA Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	28960	69305
آنسامبل	ENSG00000110063	ENSMUSG00000032040
یونی‌پروت	Q96C86	Q9DAR7
RefSeq (mRNA)	NM_001350236 NM_014026، NM_001350236	NM_027030
RefSeq (پروتئین)	NP_001337165 NP_054745، NP_001337165	NP_081306
موقعیت (UCSC)	n/a	Chr : 35.12 – 35.18 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

جهش در این ژن موجب بروز سندرم الرقاد می گردد.

جستارهای وابسته

• سندرم الرقاد

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000032040 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Liu H, Rodgers ND, Jiao X, Kiledjian M (Aug 2002). "The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases". EMBO J. 21 (17): 4699–4708. doi:10.1093/emboj/cdf448. PMC 126188. PMID 12198172.
5. van Dijk E, Le Hir H, Seraphin B (Oct 2003). "DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway". Proc Natl Acad Sci U S A. 100 (21): 12081–12086. doi:10.1073/pnas.1635192100. PMC 218716. PMID 14523240.
6. "Entrez Gene: DCPS decapping enzyme, scavenger".

• مشارکت‌کنندگان ویکی‌پدیا. «DCPS (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳۰ دسامبر ۲۰۱۷.

بیشتر بخوانید

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–1560. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Wang Z, Kiledjian M (2002). "Functional link between the mammalian exosome and mRNA decapping". Cell. 107 (6): 751–762. doi:10.1016/S0092-8674(01)00592-X. PMID 11747811.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kwasnicka DA, Krakowiak A, Thacker C, et al. (2003). "Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1". J. Biol. Chem. 278 (40): 39051–39058. doi:10.1074/jbc.M306355200. PMC 2556063. PMID 12871939.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gu M, Fabrega C, Liu SW, et al. (2004). "Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity". Mol. Cell. 14 (1): 67–80. doi:10.1016/S1097-2765(04)00180-7. PMID 15068804.
• Liu SW, Jiao X, Liu H, et al. (2004). "Functional analysis of mRNA scavenger decapping enzymes". RNA. 10 (9): 1412–1422. doi:10.1261/rna.7660804. PMC 1370627. PMID 15273322.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Malys N, Carroll K, Miyan J, Tollervey D, McCarthy JE (2004). "The 'scavenger' m7GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeast". Nucleic Acids Res. 32 (12): 3590–3600. doi:10.1093/nar/gkh687. PMC 484174. PMID 15240832.
• Chen N, Walsh MA, Liu Y, et al. (2005). "Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping". J. Mol. Biol. 347 (4): 707–718. doi:10.1016/j.jmb.2005.01.062. PMID 15769464.
• Kwaśnicka-Crawford DA, Vincent SR (2005). "Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity". Biochem. Biophys. Res. Commun. 336 (2): 565–571. doi:10.1016/j.bbrc.2005.08.129. PMID 16140270.
• Malys N, McCarthy JEG (2006). "Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies". J. Mol. Biol. 363 (2): 370–382. doi:10.1016/j.jmb.2006.08.015. PMID 16963086.