DDR1

خانواده گیرندهٔ دومین دیسکوئیدین، عضو ۱ (انگلیسی: Discoidin domain receptor family, member 1‎) که با نام CD167a هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «DDR1» کُدگذاری می‌شود.[4]

DDR1
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 3ZOS, 4AG4, 4BKJ, 4CKR, 5BVK, 5BVN, 5BVO, 5BVW, 5FDP
معین‌کننده‌ها
نام‌های دیگر	DDR1, CAK, CD167, DDR, EHGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE, discoidin domain receptor tyrosine kinase 1
شناسه‌های بیرونی	OMIM: 600408 MGI: 99216 HomoloGene: 68212 GeneCards: DDR1
Gene location (Mouse) Chr. Chromosome 17 (mouse)[1] Band 17 B1|17 18.7 cM Start 35,681,567 bp[1] End 35,704,621 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • transferase activity • nucleotide binding • protein kinase activity • collagen binding • metal ion binding • kinase activity • GO:0001948 پیوند پروتئینی • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase collagen receptor activity • protein tyrosine kinase activity • ATP binding • تیروزین کیناز گیرنده‌ای ترکیبات سلولی • integral component of membrane • membrane • receptor complex • پوسته یاخته • integral component of plasma membrane • extracellular region • extracellular exosome • extracellular space فرایند زیستی • collagen-activated tyrosine kinase receptor signaling pathway • branching involved in mammary gland duct morphogenesis • فسفرگیری • transmembrane receptor protein tyrosine kinase signaling pathway • female pregnancy • extracellular matrix organization • ear development • mammary gland alveolus development • regulation of extracellular matrix disassembly • smooth muscle cell migration • smooth muscle cell-matrix adhesion • regulation of cell-matrix adhesion • protein phosphorylation • cell adhesion • regulation of cell growth • peptidyl-tyrosine phosphorylation • lactation • wound healing, spreading of cells • embryo implantation • negative regulation of cell population proliferation • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • axon development • neuron projection extension • cell-matrix adhesion • positive regulation of cell population proliferation • دگرگونی یاخته‌ • regulation of extracellular matrix organization Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	780	12305
آنسامبل	ENSG00000215522 ENSG00000137332 ENSG00000229767 ENSG00000230456 ENSG00000234078 ENSG00000204580 ENSG00000223680	ENSMUSG00000003534
یونی‌پروت	Q08345	Q03146
RefSeq (mRNA)	NM_001202522، NM_001202523، NM_001297652، NM_001297653، NM_001297654، NM_001954، NM_013993، NM_013994، XM_006715185، XM_011514882، XM_011514883، XM_011514884، XM_011514885، XM_011514886، XM_011514887، XM_011514888، XM_017011268، XM_017011269، XM_024446540، XM_024446541، XM_024446542 NM_001202521، NM_001202522، NM_001202523، NM_001297652، NM_001297653، NM_001297654، NM_001954، NM_013993، NM_013994، XM_006715185، XM_011514882، XM_011514883، XM_011514884، XM_011514885، XM_011514886، XM_011514887، XM_011514888، XM_017011268، XM_017011269، XM_024446540، XM_024446541، XM_024446542	NM_001198833، NM_007584، NM_172962، XM_006523534، XM_006523535، XM_006523536، XM_006523537، XM_006523538، XM_011246259، XR_001782030، XM_030249460، XM_030249461، XM_030249462، XM_030249463، XM_030249464 NM_001198831، NM_001198833، NM_007584، NM_172962، XM_006523534، XM_006523535، XM_006523536، XM_006523537، XM_006523538، XM_011246259، XR_001782030، XM_030249460، XM_030249461، XM_030249462، XM_030249463، XM_030249464
RefSeq (پروتئین)	NP_001189451، NP_001189452، NP_001284581، NP_001284582، NP_001284583، NP_001945، NP_054699، NP_054700، XP_006715248، XP_011513184، XP_011513185، XP_011513186، XP_011513187، XP_011513188، XP_011513189، XP_011513190، XP_016866757، XP_016866758، XP_024302308، XP_024302309، XP_024302310 NP_001189450، NP_001189451، NP_001189452، NP_001284581، NP_001284582، NP_001284583، NP_001945، NP_054699، NP_054700، XP_006715248، XP_011513184، XP_011513185، XP_011513186، XP_011513187، XP_011513188، XP_011513189، XP_011513190، XP_016866757، XP_016866758، XP_024302308، XP_024302309، XP_024302310 NP_054699.2 NP_001284583.1، NP_054699.2	NP_001185762، NP_031610، NP_766550، XP_006523597، XP_006523598، XP_006523599، XP_006523600، XP_006523601، XP_011244561، XP_030105321، XP_030105322، XP_030105323، XP_030105324، XP_036016169، XP_036016170، XP_036016171، XP_036016172، XP_036016173 NP_001185760، NP_001185762، NP_031610، NP_766550، XP_006523597، XP_006523598، XP_006523599، XP_006523600، XP_006523601، XP_011244561، XP_030105321، XP_030105322، XP_030105323، XP_030105324، XP_036016169، XP_036016170، XP_036016171، XP_036016172، XP_036016173
موقعیت (UCSC)	n/a	Chr : 35.68 – 35.7 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

ژن یادشده بر روی بازوی کوتاه کروموزوم ۶ و در نزدیکی ژن‌های HLA-I قرار دارد.

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000003534 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: DDR1 discoidin domain receptor family, member 1".

• مشارکت‌کنندگان ویکی‌پدیا. «DDR1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۵ سپتامبر ۲۰۱۹.

برای مطالعهٔ بیشتر

• Edelhoff S, Sweetser DA, Disteche CM (Jan 1995). "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C". Genomics. 25 (1): 309–11. doi:10.1016/0888-7543(95)80144-B. PMID 7774938.
• Shelling AN, Butler R, Jones T, Laval S, Boyle JM, Ganesan TS (Jan 1995). "Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16". Genomics. 25 (2): 584–7. doi:10.1016/0888-7543(95)80065-T. PMID 7789998.
• Weiner TM, Liu ET, Craven RJ, Cance WG (Jan 1994). "Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors". Annals of Surgical Oncology. 1 (1): 18–27. doi:10.1007/BF02303537. PMID 7834423.
• Laval S, Butler R, Shelling AN, Hanby AM, Poulsom R, Ganesan TS (Nov 1994). "Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line". Cell Growth & Differentiation. 5 (11): 1173–83. PMID 7848919.
• Kato JY, Matsuoka M, Strom DK, Sherr CJ (Apr 1994). "Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase". Molecular and Cellular Biology. 14 (4): 2713–21. doi:10.1128/MCB.14.4.2713. PMC 358637. PMID 8139570.
• Di Marco E, Cutuli N, Guerra L, Cancedda R, De Luca M (Nov 1993). "Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues". The Journal of Biological Chemistry. 268 (32): 24290–5. PMID 8226977.
• Perez JL, Shen X, Finkernagel S, Sciorra L, Jenkins NA, Gilbert DJ, Copeland NG, Wong TW (Jan 1994). "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain". Oncogene. 9 (1): 211–9. PMID 8302582.
• Johnson JD, Edman JC, Rutter WJ (Jun 1993). "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain". Proceedings of the National Academy of Sciences of the United States of America. 90 (12): 5677–81. doi:10.1073/pnas.90.12.5677. PMC 46784. PMID 8390675.
• Perez JL, Jing SQ, Wong TW (Apr 1996). "Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines". Oncogene. 12 (7): 1469–77. PMID 8622863.
• Valent A, Meddeb M, Danglot G, Duverger A, Nguyen VC, Bernheim A (Jul 1996). "Assignment of the NTRK4 (trkE) gene to chromosome 6p21". Human Genetics. 98 (1): 12–5. doi:10.1007/s004390050152. PMID 8682498.
• Playford MP, Butler RJ, Wang XC, Katso RM, Cooke IE, Ganesan TS (Jul 1996). "The genomic structure of discoidin receptor tyrosine kinase". Genome Research. 6 (7): 620–7. doi:10.1101/gr.6.7.620. PMID 8796349.
• Sakuma S, Saya H, Tada M, Nakao M, Fujiwara T, Roth JA, Sawamura Y, Shinohe Y, Abe H (Dec 1996). "Receptor protein tyrosine kinase DDR is up-regulated by p53 protein". FEBS Letters. 398 (2–3): 165–9. doi:10.1016/S0014-5793(96)01234-3. PMID 8977099.
• Nemoto T, Ohashi K, Akashi T, Johnson JD, Hirokawa K (1998). "Overexpression of protein tyrosine kinases in human esophageal cancer". Pathobiology. 65 (4): 195–203. doi:10.1159/000164123. PMID 9396043.
• Tanaka K, Nagayama Y, Nakano T, Takamura N, Namba H, Fukada S, Kuma K, Yamashita S, Niwa M (Mar 1998). "Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid". Endocrinology. 139 (3): 852–8. doi:10.1210/en.139.3.852. PMID 9492013.
• Vogel W, Gish GD, Alves F, Pawson T (Dec 1997). "The discoidin domain receptor tyrosine kinases are activated by collagen". Molecular Cell. 1 (1): 13–23. doi:10.1016/S1097-2765(00)80003-9. PMID 9659899.
• Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, Davis S, Goldfarb MP, Glass DJ, Lemke G, Yancopoulos GD (Dec 1997). "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors". Molecular Cell. 1 (1): 25–34. doi:10.1016/S1097-2765(00)80004-0. PMID 9659900.
• Vogel W, Brakebusch C, Fässler R, Alves F, Ruggiero F, Pawson T (Feb 2000). "Discoidin domain receptor 1 is activated independently of beta(1) integrin". The Journal of Biological Chemistry. 275 (8): 5779–84. doi:10.1074/jbc.275.8.5779. PMID 10681566.
• Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA (May 2000). "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors". FASEB Journal. 14 (7): 973–81. PMID 10783152.
• Weiner HL, Huang H, Zagzag D, Boyce H, Lichtenbaum R, Ziff EB (Dec 2000). "Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors". Neurosurgery. 47 (6): 1400–9. doi:10.1097/00006123-200012000-00028. PMID 11126911.
• Mohan RR, Mohan RR, Wilson SE (Jan 2001). "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea". Experimental Eye Research. 72 (1): 87–92. doi:10.1006/exer.2000.0932. PMID 11133186.