GNAI1

پروتئین جی متصل‌شونده به نوکلئوتید گوانین، زیرواحد آلفا-۱ (انگلیسی: Guanine nucleotide-binding protein G(i), alpha-1 subunit‎) یک پروتئین است که در انسان توسط ژن «GNAI1» کُدگذاری می‌شود.[4][5]

GNAI1
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 1KJY, 1Y3A, 2G83, 2GTP, 2IK8, 2OM2, 2XNS, 3ONW, 3QE0, 3QI2, 3UMR, 3UMS, 4G5Q, 5JS7, 5JS8
معین‌کننده‌ها
نام‌های دیگر	GNAI1, Gi, G protein subunit alpha i1
شناسه‌های بیرونی	OMIM: 139310 MGI: 95771 HomoloGene: 74417 GeneCards: GNAI1
Gene location (Mouse) Chr. Chromosome 5 (mouse)[1] Band 5 A3|5 8.16 cM Start 18,265,135 bp[1] End 18,360,355 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • GTPase activating protein binding • nucleotide binding • G-protein beta/gamma-subunit complex binding • GDP binding • G protein-coupled serotonin receptor binding • signal transducer activity • metal ion binding • GO:0001948 پیوند پروتئینی • guanyl nucleotide binding • G protein-coupled receptor binding • GTP binding • magnesium ion binding • GO:0006184 GTPase activity ترکیبات سلولی • سیتوپلاسم • میان‌تن • membrane • پوسته یاخته • intracellular anatomical structure • microtubule organizing center • lysosomal membrane • midbody • heterotrimeric G-protein complex • لیپید رفت • extracellular exosome • اسکلت سلولی • هسته یاخته • هستک • cell cortex region • cell cortex • protein-containing complex فرایند زیستی • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to peptide hormone • negative regulation of synaptic transmission • تقسیم یاخته • چرخه یاخته‌ای • ورارسانی پیام • regulation of cAMP-mediated signaling • cellular response to forskolin • تاشدگی پروتئین • regulation of mitotic spindle organization • positive regulation of protein localization to cell cortex • transport • G protein-coupled receptor signaling pathway Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	2770	14677
آنسامبل	ENSG00000127955	ENSMUSG00000057614
یونی‌پروت	P63096	B2RSH2
RefSeq (mRNA)	NM_001256414 NM_002069، NM_001256414	NM_010305
RefSeq (پروتئین)	NP_002060 NP_001243343، NP_002060	NP_034435
موقعیت (UCSC)	n/a	Chr : 18.27 – 18.36 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000057614 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (Aug 1987). "Human cDNA clones for an alpha subunit of Gi signal-transduction protein". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5115–9. doi:10.1073/pnas.84.15.5115. PMC 298804. PMID 3110783.
5. "Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1".

• مشارکت‌کنندگان ویکی‌پدیا. «GNAI1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳۰ دسامبر ۲۰۱۸.

برای مطالعهٔ بیشتر

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• Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.
• De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788. Check date values in: |year= / |date= mismatch (help)
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