GRB7

GRB7
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PQZ, 1MW4, 1WGR, 2L4K, 2QMS, 4WWQ, 4X6S, 5EEL, 5EEQ, 5D0J
معین‌کننده‌ها
نام‌های دیگر	GRB7, entrez:2886, growth factor receptor bound protein 7
شناسه‌های بیرونی	OMIM: 601522 MGI: 102683 HomoloGene: 3881 GeneCards: GRB7
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[1]
End	98,455,373 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948 پیوند پروتئینی; • phosphatidylinositol binding; • identical protein binding; • RNA binding; • protein kinase binding; • lipid binding;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • cell projection; • membrane; • focal adhesion; • پوسته یاخته; • پیوند میان‌یاخته‌ای; • cytoplasmic stress granule;
فرایند زیستی	• negative regulation of translation; • epidermal growth factor receptor signaling pathway; • positive regulation of cell migration; • leukocyte migration; • ورارسانی پیام; • stress granule assembly; • ERBB2 signaling pathway; • positive regulation of signal transduction; • axon guidance; • insulin receptor signaling pathway; • negative regulation of insulin receptor signaling pathway;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2886
	14786
	ENSG00000141738
	ENSMUSG00000019312
	Q14451
	Q03160
	NM_001242442، NM_001242443، NM_005310، NM_001330207، XM_024450729 NM_001030002، NM_001242442، NM_001242443، NM_005310، NM_001330207، XM_024450729
	XM_006532233، XM_030245575 NM_010346، XM_006532233، XM_030245575
	NP_001229371، NP_001229372، NP_001317136، NP_005301، XP_024306497 NP_001025173، NP_001229371، NP_001229372، NP_001317136، NP_005301، XP_024306497
	XP_006532296، XP_030101435 NP_034476، XP_006532296، XP_030101435
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین شمارهٔ ۷ متصل به گیرندهٔ فاکتور رشد (انگلیسی: Growth factor receptor-bound protein 7‎) که با نام اختصاری «GRB7» شناخته می‌شود، پروتئینی است که در انسان توسط ژن «GRB7» کد می‌شود.[4][5] این ژن بر روی بازوی باندِ کروموزوم ۱۷ قرار دارد.

این پروتئین متعلق یه خانوادهٔ کوچک «پروتئین‌های تعدیل‌کننده» است که با برخی ملکول‌های پیام‌ده و تیروزین کینازهای گیرنده‌ای واکنش نشان می‌دهند.

بیش‌فعالی این ژن با بروز برخی انواع سرطان بیضه، سرطان پستان، سرطان معده و سرطان مری در ارتباط است.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000019312 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: GRB7 growth factor receptor-bound protein 7".
Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K (Aug 1998). "A novel variant of human Grb7 is associated with invasive esophageal carcinoma". The Journal of Clinical Investigation. 102 (4): 821–7. doi:10.1172/JCI2921. PMC 508945. PMID 9710451.

مشارکت‌کنندگان ویکی‌پدیا. «GRB7». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ نوامبر ۲۰۱۷.

بیشتر بخوانید

Han DC, Shen TL, Guan JL (Oct 2001). "The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions". Oncogene. 20 (44): 6315–21. doi:10.1038/sj.onc.1204775. PMID 11607834.
Margolis B, Silvennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, Schlessinger J (Oct 1992). "High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 8894–8. doi:10.1073/pnas.89.19.8894. PMC 50030. PMID 1409582.
Skotheim RI, Abeler VM, Nesland JM, Fosså SD, Holm R, Wagner U, Flørenes VA, Aass N, Kallioniemi OP, Lothe RA (2003). "Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays". Neoplasia. 5 (5): 397–404. doi:10.1016/s1476-5586(03)80042-8. PMC 1502610. PMID 14670177.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Pandey A, Liu X, Dixon JE, Di Fiore PP, Dixit VM (May 1996). "Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7". The Journal of Biological Chemistry. 271 (18): 10607–10. doi:10.1074/jbc.271.18.10607. PMID 8631863.
Yokote K, Margolis B, Heldin CH, Claesson-Welsh L (Nov 1996). "Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors". The Journal of Biological Chemistry. 271 (48): 30942–9. doi:10.1074/jbc.271.48.30942. PMID 8940081.
Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K (Jan 1997). "Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma". Cancer Research. 57 (1): 28–31. PMID 8988034.
Janes PW, Lackmann M, Church WB, Sanderson GM, Sutherland RL, Daly RJ (Mar 1997). "Structural determinants of the interaction between the erbB2 receptor and the Src homology 2 domain of Grb7". The Journal of Biological Chemistry. 272 (13): 8490–7. doi:10.1074/jbc.272.13.8490. PMID 9079677.
Kishi T, Sasaki H, Akiyama N, Ishizuka T, Sakamoto H, Aizawa S, Sugimura T, Terada M (Mar 1997). "Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer". Biochemical and Biophysical Research Communications. 232 (1): 5–9. doi:10.1006/bbrc.1997.6218. PMID 9125150.
Dong LQ, Du H, Porter SG, Kolakowski LF, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F, Mandarino J (Nov 1997). "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma". The Journal of Biological Chemistry. 272 (46): 29104–12. doi:10.1074/jbc.272.46.29104. PMID 9360986.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Fiddes RJ, Campbell DH, Janes PW, Sivertsen SP, Sasaki H, Wallasch C, Daly RJ (Mar 1998). "Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3". The Journal of Biological Chemistry. 273 (13): 7717–24. doi:10.1074/jbc.273.13.7717. PMID 9516479.
Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K (Aug 1998). "A novel variant of human Grb7 is associated with invasive esophageal carcinoma". The Journal of Clinical Investigation. 102 (4): 821–7. doi:10.1172/JCI2921. PMC 508945. PMID 9710451.
Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L (Jul 1999). "Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor". The Biochemical Journal. 341 (1): 211–6. doi:10.1042/0264-6021:3410211. PMC 1220349. PMID 10377264.
Han DC, Guan JL (Aug 1999). "Association of focal adhesion kinase with Grb7 and its role in cell migration". The Journal of Biological Chemistry. 274 (34): 24425–30. doi:10.1074/jbc.274.34.24425. PMID 10446223.
Jones N, Master Z, Jones J, Bouchard D, Gunji Y, Sasaki H, Daly R, Alitalo K, Dumont DJ (Oct 1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration". The Journal of Biological Chemistry. 274 (43): 30896–905. doi:10.1074/jbc.274.43.30896. PMID 10521483.
Vayssière B, Zalcman G, Mahé Y, Mirey G, Ligensa T, Weidner KM, Chardin P, Camonis J (Feb 2000). "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family". FEBS Letters. 467 (1): 91–6. doi:10.1016/S0014-5793(99)01530-6. PMID 10664463.
Kasus-Jacobi A, Béréziat V, Perdereau D, Girard J, Burnol AF (Apr 2000). "Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2". Oncogene. 19 (16): 2052–9. doi:10.1038/sj.onc.1203469. PMID 10803466.
Han DC, Shen TL, Guan JL (Sep 2000). "Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration". The Journal of Biological Chemistry. 275 (37): 28911–7. doi:10.1074/jbc.M001997200. PMID 10893408.
Lee H, Volonte D, Galbiati F, Iyengar P, Lublin DM, Bregman DB, Wilson MT, Campos-Gonzalez R, Bouzahzah B, Pestell RG, Scherer PE, Lisanti MP (Nov 2000). "Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette". Molecular Endocrinology. 14 (11): 1750–75. doi:10.1210/me.14.11.1750. PMID 11075810.
Skotheim RI, Abeler VM, Nesland JM, Fosså SD, Holm R, Wagner U, Flørenes VA, Aass N, Kallioniemi OP, Lothe RA (2003). "Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays". Neoplasia. 5 (5): 397–404. doi:10.1016/s1476-5586(03)80042-8. PMC 1502610. PMID 14670177.

پیوند به بیرون

GRB7 Adaptor Protein در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000019312 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: GRB7 growth factor receptor-bound protein 7".

[pmid_9710451-5] Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K (Aug 1998). "A novel variant of human Grb7 is associated with invasive esophageal carcinoma". The Journal of Clinical Investigation. 102 (4): 821–7. doi:10.1172/JCI2921. PMC 508945. PMID 9710451.