HDAC5

HDAC5
معین‌کننده‌ها
نام‌های دیگر	HDAC5, HD5, NY-CO-9, histone deacetylase 5
شناسه‌های بیرونی	OMIM: 605315 MGI: 1333784 HomoloGene: 3995 GeneCards: HDAC5
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[1]
End	102,230,166 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• NAD-dependent histone deacetylase activity (H3-K14 specific); • protein deacetylase activity; • histone deacetylase binding; • chromatin binding; • metal ion binding; • GO:0001948 پیوند پروتئینی; • hydrolase activity; • protein kinase C binding; • histone deacetylase activity; • transcription factor binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
ترکیبات سلولی	• دستگاه گلژی; • histone deacetylase complex; • سیتوپلاسم; • هسته یاخته; • نوکلئوپلاسم; • سیتوزول; • nuclear speck; • protein-containing complex;
فرایند زیستی	• histone H3 deacetylation; • chromatin remodeling; • regulation of myotube differentiation; • chromatin silencing; • regulation of transcription, DNA-templated; • regulation of gene expression, epigenetic; • positive regulation of DNA-binding transcription factor activity; • regulation of histone H3-K9 acetylation; • response to activity; • transcription, DNA-templated; • protein deacetylation; • negative regulation of cell migration involved in sprouting angiogenesis; • B cell activation; • neuron differentiation; • negative regulation of myotube differentiation; • cellular response to insulin stimulus; • B cell differentiation; • inflammatory response; • regulation of protein binding; • negative regulation of transcription, DNA-templated; • cellular response to lipopolysaccharide; • response to drug; • positive regulation of transcription by RNA polymerase II; • response to cocaine; • negative regulation of transcription by RNA polymerase II; • histone deacetylation; • chromatin organization;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	10014
	15184
	ENSG00000108840
	ENSMUSG00000008855
	Q9UQL6
	Q9Z2V6
	NM_005474، NM_139205، XM_005256905، XM_011524149، XM_011524150، XM_017023988، XM_017023989، XM_017023990، XM_017023991، XM_017023992، XM_017023993، XM_017023996، NM_001382393 NM_001015053، NM_005474، NM_139205، XM_005256905، XM_011524149، XM_011524150، XM_017023988، XM_017023989، XM_017023990، XM_017023991، XM_017023992، XM_017023993، XM_017023996، NM_001382393
	NM_001284248، NM_001284249، NM_001284250، NM_010412، XM_006532254، XM_011248747، XM_011248748، XM_011248749، XM_011248750، XM_011248752، XM_011248754، XM_011248755، XM_017314281، XM_017314282، XR_001779878، XR_001779879، NM_001361596 NM_001077696، NM_001284248، NM_001284249، NM_001284250، NM_010412، XM_006532254، XM_011248747، XM_011248748، XM_011248749، XM_011248750، XM_011248752، XM_011248754، XM_011248755، XM_017314281، XM_017314282، XR_001779878، XR_001779879، NM_001361596
	NP_005465، XP_005256962، XP_011522451، XP_011522452، XP_016879477، XP_016879478، XP_016879479، XP_016879480، XP_016879481، XP_016879482، XP_016879485، NP_001369322 NP_001015053، NP_005465، XP_005256962، XP_011522451، XP_011522452، XP_016879477، XP_016879478، XP_016879479، XP_016879480، XP_016879481، XP_016879482، XP_016879485، NP_001369322
	n/a
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

هیستون دِاَستیلاز ۵ (انگلیسی: Histone deacetylase 5‎) یک آنزیم است که در انسان توسط ژن «HDAC5» کُدگذاری می‌شود.[4][5][6]

این پروتئین نقش بسیار مهمی در تنظیم رونویسی ژن‌ها، پیشرفتِ چرخهٔ سلولی و وقایع تکاملی سلول دارد.

هیستون دِاَستیلاز ۵ با مولکول‌های GATA1[7] و ZBTB16[8][9] تعامل پروتئین-پروتئین دارد.

اهمیت بالینی

این آنزیم در فرایند «تثبیت حافظه» (Memory consolidation) نقش دارد و به همین سبب ممکن است ساخت «بازدارنده‌های اختصاصی هیستون دِاَستیلاز» که هیستون دِاَستیلاز ۵ را هدف قرار می‌دهند، در درمان بیماری آلزایمر مؤثر باشد.[10]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000008855 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Grozinger CM, Hassig CA, Schreiber SL (June 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proc Natl Acad Sci U S A. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (June 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
"Entrez Gene: HDAC5 histone deacetylase 5".
Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, Naoe T, Saito H (2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene. 22 (57): 9176–84. doi:10.1038/sj.onc.1206902. PMID 14668799.
Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.
Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A (2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene. 23 (54): 8777–84. doi:10.1038/sj.onc.1208128. PMID 15467736.
Agis-Balboa RC, Pavelka Z, Kerimoglu C, Fischer A (January 2013). "Loss of HDAC5 impairs memory function: implications for Alzheimer's disease". J Alzheimers Dis. 33 (1): 35–44. doi:10.3233/JAD-2012-121009. hdl:2434/223089. PMID 22914591.

مشارکت‌کنندگان ویکی‌پدیا. «Histone deacetylase 5». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۱ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

Verdin E, Dequiedt F, Kasler HG (2003). "Class II histone deacetylases: versatile regulators" (PDF). Trends Genet. 19 (5): 286–93. doi:10.1016/S0168-9525(03)00073-8. PMID 12711221.
Huang EY, Zhang J, Miska EA, et al. (2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes Dev. 14 (1): 45–54. PMC 316335. PMID 10640275.
Lemercier C, Verdel A, Galloo B, et al. (2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity". J. Biol. Chem. 275 (20): 15594–9. doi:10.1074/jbc.M908437199. PMID 10748098.
Grozinger CM, Schreiber SL (2000). "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3- 3-dependent cellular localization". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7835–40. doi:10.1073/pnas.140199597. PMC 16631. PMID 10869435.
Huynh KD, Fischle W, Verdin E, Bardwell VJ (2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes Dev. 14 (14): 1810–23. doi:10.1101/gad.14.14.1810 (inactive 2020-01-22). PMC 316791. PMID 10898795.
Mahlknecht U, Schnittger S, Ottmann OG, et al. (2000). "Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5)". Biochim. Biophys. Acta. 1493 (3): 342–8. doi:10.1016/S0167-4781(00)00191-3. PMID 11018260.
Zhang CL, McKinsey TA, Lu JR, Olson EN (2001). "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor". J. Biol. Chem. 276 (1): 35–9. doi:10.1074/jbc.M007364200. PMID 11022042.
McKinsey TA, Zhang CL, Lu J, Olson EN (2000). "Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation". Nature. 408 (6808): 106–11. doi:10.1038/35040593. PMC 4459600. PMID 11081517.
McKinsey TA, Zhang CL, Olson EN (2001). "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14400–5. doi:10.1073/pnas.260501497. PMC 18930. PMID 11114197.
Fischle W, Dequiedt F, Fillion M, et al. (2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.
McKinsey TA, Zhang CL, Olson EN (2001). "Identification of a Signal-Responsive Nuclear Export Sequence in Class II Histone Deacetylases". Mol. Cell. Biol. 21 (18): 6312–21. doi:10.1128/MCB.21.18.6312-6321.2001. PMC 87361. PMID 11509672.
Ozawa Y, Towatari M, Tsuzuki S, et al. (2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2". Blood. 98 (7): 2116–23. doi:10.1182/blood.V98.7.2116. PMID 11567998.
Potter GB, Beaudoin GM, DeRenzo CL, et al. (2001). "The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor". Genes Dev. 15 (20): 2687–701. doi:10.1101/gad.916701. PMC 312820. PMID 11641275.
Fischle W, Dequiedt F, Hendzel MJ, et al. (2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell. 9 (1): 45–57. doi:10.1016/S1097-2765(01)00429-4. PMID 11804585.
Lemercier C, Brocard MP, Puvion-Dutilleul F, et al. (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.
Huang Y, Tan M, Gosink M, et al. (2002). "Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis". Cancer Res. 62 (10): 2913–22. PMID 12019172.

پیوند به بیرون

HDAC5 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000008855 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10220385-4] Grozinger CM, Hassig CA, Schreiber SL (June 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proc Natl Acad Sci U S A. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.

[pmid9610721-5] Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (June 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.

[entrez-6] "Entrez Gene: HDAC5 histone deacetylase 5".

[pmid14668799-7] Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, Naoe T, Saito H (2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation". Oncogene. 22 (57): 9176–84. doi:10.1038/sj.onc.1206902. PMID 14668799.

[pmid11929873-8] Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.

[pmid15467736-9] Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A (2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene. 23 (54): 8777–84. doi:10.1038/sj.onc.1208128. PMID 15467736.

[pmid22914591-10] Agis-Balboa RC, Pavelka Z, Kerimoglu C, Fischer A (January 2013). "Loss of HDAC5 impairs memory function: implications for Alzheimer's disease". J Alzheimers Dis. 33 (1): 35–44. doi:10.3233/JAD-2012-121009. hdl:2434/223089. PMID 22914591.