IRAK3

IRAK3
معین‌کننده‌ها
نام‌های دیگر	IRAK3, ASRT5, IRAKM, interleukin 1 receptor associated kinase 3
شناسه‌های بیرونی	OMIM: 604459 MGI: 1921164 HomoloGene: 36215 GeneCards: IRAK3
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[1]
End	120,202,130 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• nucleotide binding; • protein kinase activity; • transferase activity; • magnesium ion binding; • protein serine/threonine kinase activity; • kinase activity; • protein homodimerization activity; • protein heterodimerization activity; • ATP binding; • GO:0001948 پیوند پروتئینی;
ترکیبات سلولی	• سیتوپلاسم; • هسته یاخته; • پوسته یاخته;
فرایند زیستی	• response to lipopolysaccharide; • negative regulation of innate immune response; • ورارسانی پیام; • negative regulation of macrophage cytokine production; • protein autophosphorylation; • negative regulation of protein-containing complex disassembly; • response to interleukin-1; • response to exogenous dsRNA; • protein phosphorylation; • negative regulation of toll-like receptor signaling pathway; • cytokine-mediated signaling pathway; • response to virus; • response to peptidoglycan; • negative regulation of cytokine-mediated signaling pathway; • regulation of protein-containing complex disassembly; • positive regulation of macrophage tolerance induction; • negative regulation of NF-kappaB transcription factor activity; • فسفرگیری; • negative regulation of protein catabolic process; • negative regulation of interleukin-6 production; • interleukin-1-mediated signaling pathway; • positive regulation of NF-kappaB transcription factor activity; • مپ کیناز; • negative regulation of tumor necrosis factor production; • negative regulation of interleukin-12 production; • MyD88-dependent toll-like receptor signaling pathway; • GO:0007243 intracellular signal transduction;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	11213
	73914
	ENSG00000090376
	ENSMUSG00000020227
	Q9Y616
	Q8K4B2
	NM_001142523 NM_007199، NM_001142523
	XM_006514227، XM_006514228، NM_001359184، NR_152856 NM_028679، XM_006514227، XM_006514228، NM_001359184، NR_152856
	NP_009130 NP_001135995، NP_009130
	NP_001346113 NP_082955، NP_001346113
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

IRAK3 (انگلیسی: IRAK3‎) یا «کیناز ۳ مرتبط با گیرندهٔ اینترلوکین ۱» نام یک آنزیم است که در انسان توسط ژن «IRAK3» کُد می‌شود.[4][5]

این ژن بر روی کروموزوم ۱۲ قرار دارد.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000020227 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J Biol Chem. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
"Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".

مشارکت‌کنندگان ویکی‌پدیا. «IRAK3». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۹ اکتبر ۲۰۱۷.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000020227 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_10383454-4] Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (Jul 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J Biol Chem. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.

[entrez-5] "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".