LAIR1

گیرندهٔ شبه ایمونوگلوبولینی ۱ وابسته به لکوسیت (انگلیسی: Leukocyte-associated immunoglobulin-like receptor 1‎) که با نام CD305 هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «LAIR1» کُدگذاری می‌شود.[4][5]

LAIR1
ساختارهای موجود
PDBOrtholog search: PDBe RCSB
معین‌کننده‌ها
نام‌های دیگرLAIR1, CD305, LAIR-1, leukocyte associated immunoglobulin like receptor 1
شناسه‌های بیرونیOMIM: 602992 MGI: 105492 HomoloGene: 48097 GeneCards: LAIR1
الگوی گسترش RNA


More reference expression data
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

3903

52855

آنسامبل

ENSMUSG00000055541

یونی‌پروت

Q6GTX8

Q8BG84

RefSeq (mRNA)

NM_001289025، NM_001289026، NM_001289027، NM_002287، NM_021706، NM_021708، NR_110279، NR_110280، XM_017026803 NM_001289023، NM_001289025، NM_001289026، NM_001289027، NM_002287، NM_021706، NM_021708، NR_110279، NR_110280، XM_017026803

NM_178611، XM_006540175، XM_006540176، XM_006540179، XM_006540183، NM_001302675، NM_001302676، NM_001302677، NM_001302681، NM_001302682، NM_001302683، XM_017322357، XM_017322358، XM_017322359 NM_001113474، NM_178611، XM_006540175، XM_006540176، XM_006540179، XM_006540183، NM_001302675، NM_001302676، NM_001302677، NM_001302681، NM_001302682، NM_001302683، XM_017322357، XM_017322358، XM_017322359

RefSeq (پروتئین)

NP_001275954، NP_001275955، NP_001275956، NP_002278، NP_068352، XP_016882292 NP_001275952، NP_001275954، NP_001275955، NP_001275956، NP_002278، NP_068352، XP_016882292

NP_001289604، NP_001289605، NP_001289606، NP_001289610، NP_001289611، NP_001289612، NP_848726، XP_006540238، XP_006540239، XP_006540242، XP_006540246، XP_036009133 NP_001106945، NP_001289604، NP_001289605، NP_001289606، NP_001289610، NP_001289611، NP_001289612، NP_848726، XP_006540238، XP_006540239، XP_006540242، XP_006540246، XP_036009133

موقعیت (UCSC)n/aChr : 4 – 4.06 Mb
جستجوی PubMed[2][3]
ویکی‌داده
مشاهده/ویرایش HumanView/Edit Mouse

این پروتئین بر روی سطح سلول‌های چندهسته‌ای محیطی نظیر لنفوسیت‌های تی، بی و سلول‌های کُشندهٔ طبیعی یافت می‌شود.[6]

منابع
  1. GRCm38: Ensembl release 89: ENSMUSG00000055541 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (September 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity. 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. PMID 9285412.
  5. "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1".
  6. van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (October 1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". European Journal of Immunology. 29 (10): 3160–7. doi:10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S. PMID 10540327.

برای مطالعهٔ بیشتر
  • Sinclair NR (1999). "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. doi:10.1046/j.1365-3083.1999.00580.x. PMID 10404045.
  • Meyaard L (1999). "LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells". Curr. Top. Microbiol. Immunol. Current Topics in Microbiology 244 and Immunology. 244: 151–7. doi:10.1007/978-3-642-58537-1_13. ISBN 978-3-540-65789-7. PMID 10453657.
  • Meyaard L (2004). "Leukocyte associated Ig-like receptor (LAIR)". J. Biol. Regul. Homeost. Agents. 17 (4): 330–3. PMID 15065762.
  • Poggi A, Tomasello E, Ferrero E, Zocchi MR, Moretta L (1998). "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor". Eur. J. Immunol. 28 (7): 2086–91. doi:10.1002/(SICI)1521-4141(199807)28:07<2086::AID-IMMU2086>3.0.CO;2-T. PMID 9692876.
  • Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. PMID 10229813.
  • Poggi A, Pellegatta F, Leone BE, Moretta L, Zocchi MR (2000). "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias". Eur. J. Immunol. 30 (10): 2751–8. doi:10.1002/1521-4141(200010)30:10<2751::AID-IMMU2751>3.0.CO;2-L. PMID 11069054.
  • Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ (2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. doi:10.4049/jimmunol.166.3.1763. PMID 11160222.
  • Saverino D, Fabbi M, Merlo A, Ravera G, Grossi CE, Ciccone E (2002). "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions". Hum. Immunol. 63 (7): 534–46. doi:10.1016/S0198-8859(02)00409-3. PMID 12072189.
  • Aoukaty A, Lee IF, Wu J, Tan R (2003). "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells". J. Clin. Immunol. 23 (2): 141–5. doi:10.1023/A:1022580929226. PMID 12757266.
  • Verbrugge A, de Ruiter T, Clevers H, Meyaard L (2003). "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment". Int. Immunol. 15 (11): 1349–58. doi:10.1093/intimm/dxg134. PMID 14565933.
  • De Milito A, Nilsson A, Titanji K, Thorstensson R, Reizenstein E, Narita M, Grutzmeier S, Sönnerborg A, Chiodi F (2004). "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection". Blood. 103 (6): 2180–6. doi:10.1182/blood-2003-07-2375. PMID 14604962.

پیوند به بیرون
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.