NLGN2

نورولایگین-۲ (به انگلیسی: Neuroligin-2) یک پروتئین است که در انسان توسط ژن «NLGN2» کُدگذاری می‌شود.[4][5][6]

NLGN2
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 3BL8
معین‌کننده‌ها
نام‌های دیگر	NLGN2, neuroligin 2
شناسه‌های بیرونی	OMIM: 606479 MGI: 2681835 HomoloGene: 69317 GeneCards: NLGN2
Gene location (Mouse) Chr. Chromosome 11 (mouse)[1] Band 11|11 B3 Start 69,823,122 bp[1] End 69,837,784 bp[1]
هستی‌شناسی ژن عملکرد ملکولی • GO:0004091 carboxylic ester hydrolase activity • neurexin family protein binding • cell adhesion molecule binding • signaling receptor activity • identical protein binding ترکیبات سلولی • integral component of membrane • postsynaptic membrane • membrane • سیناپس • inhibitory synapse • cell surface • پیوند میان‌یاخته‌ای • presynaptic membrane • پوسته یاخته • integral component of plasma membrane • integral component of postsynaptic membrane • intracellular anatomical structure • spanning component of membrane • glycinergic synapse • dopaminergic synapse • GABA-ergic synapse • symmetric, GABA-ergic, inhibitory synapse • integral component of postsynaptic specialization membrane فرایند زیستی • neuromuscular process controlling balance • neuron cell-cell adhesion • positive regulation of inhibitory postsynaptic potential • synapse organization • modulation of chemical synaptic transmission • positive regulation of protein localization to synapse • gephyrin clustering involved in postsynaptic density assembly • postsynaptic density protein 95 clustering • positive regulation of synaptic transmission, GABAergic • regulation of AMPA receptor activity • locomotory exploration behavior • regulation of respiratory gaseous exchange by nervous system process • cell-cell junction maintenance • positive regulation of synaptic vesicle clustering • positive regulation of synaptic transmission, glutamatergic • cell adhesion • positive regulation of excitatory postsynaptic potential • sensory perception of pain • terminal button organization • protein localization to synapse • positive regulation of insulin secretion • positive regulation of synapse assembly • inhibitory synapse assembly • synapse assembly • synaptic vesicle endocytosis • postsynaptic membrane assembly • presynaptic membrane assembly • cell-cell adhesion • postsynaptic specialization assembly • presynapse assembly Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	57555	216856
آنسامبل	ENSG00000169992 ENSG00000283859	ENSMUSG00000051790
یونی‌پروت	Q8NFZ4	Q69ZK9
RefSeq (mRNA)	NM_020795، XM_017024897 XM_005256744، NM_020795، XM_017024897	XM_006532902، XM_006532903، NM_001364137 NM_198862، XM_006532902، XM_006532903، NM_001364137
RefSeq (پروتئین)	XP_005256801، XP_016880386 NP_065846، XP_005256801، XP_016880386	XP_006532965، NP_001351066 NP_942562، XP_006532965، NP_001351066
موقعیت (UCSC)	n/a	Chr : 69.82 – 69.84 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

این پروتئین در شکل‌گیری و بازسازی سیناپس‌های دستگاه عصبی مرکزی نقش دارد.[6]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000051790 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
5. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
6. "Entrez Gene: NLGN2 neuroligin 2".

• مشارکت‌کنندگان ویکی‌پدیا. «NLGN2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۰ مه ۲۰۱۸.

بیشتر بخوانید

• Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ...". Curr. Biol. 10 (17): R620–3. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085.
• Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240.
• Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515.
• Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Scheiffele P, Fan J, Choih J, et al. (2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell. 101 (6): 657–69. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMC 1925054. PMID 12669065.