OGN

اُستئوگلیسین (انگلیسی: Osteoglycin‎) که با نام «میمیکَن» هم شناخته می‌شود، نام پروتئینی است که در انسان توسط ژن «OGN» کُد می‌شود.[4]

OGN
معین‌کننده‌ها
نام‌های دیگر	OGN, OG, OIF, SLRR3A, osteoglycin
شناسه‌های بیرونی	OMIM: 602383 MGI: 109278 HomoloGene: 8542 GeneCards: OGN
Gene location (Mouse) Chr. Chromosome 13 (mouse)[1] Band 13|13 A5 Start 49,608,046 bp[1] End 49,624,501 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • GO:0001948 پیوند پروتئینی • growth factor activity • extracellular matrix structural constituent conferring compression resistance ترکیبات سلولی • extracellular vesicle • GO:0005578 بافت‌مانه برون‌یاخته‌ای • lysosomal lumen • Golgi lumen • extracellular exosome • extracellular space • extracellular region • collagen-containing extracellular matrix فرایند زیستی • negative regulation of smooth muscle cell proliferation • axonogenesis • keratan sulfate catabolic process • keratan sulfate biosynthetic process • regulation of signaling receptor activity • ورارسانی پیام Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	4969	18295
آنسامبل	ENSG00000106809	ENSMUSG00000021390
یونی‌پروت	P20774	Q62000
RefSeq (mRNA)	NM_014057، NM_024416 NM_033014، NM_014057، NM_024416	NM_008760
RefSeq (پروتئین)	NP_077727، NP_148935 NP_054776، NP_077727، NP_148935 NP_148935.1 NP_054776.1، NP_148935.1	NP_032786
موقعیت (UCSC)	n/a	Chr : 49.61 – 49.62 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

این پروتئین در کنار TGF-β موجب استخوان‌سازی نابجا در بافت‌های دیگر می‌شود.

میزان بیان ژنی این پروتئین، با بروز کاردیومگالی و به‌ویژه هیپرتروفی بطن چپ در ارتباط است.[5][6]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000021390 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: OGN osteoglycin".
5. "Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. Retrieved 2008-06-07.
6. Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC 2742198. PMID 18443592.

• مشارکت‌کنندگان ویکی‌پدیا. «OGN (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۲ دسامبر ۲۰۱۷.

بیشتر بخوانید

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