PHB2

پروهیبیتین ۲ (انگلیسی: Prohibitin-2‎) یک پروتئین است که در انسان توسط ژن «PHB2» کُدگذاری می‌شود.[4][5][6]

PHB2
معین‌کننده‌ها
نام‌های دیگر	PHB2, BAP, BCAP37, Bap37, PNAS-141, REA, p22, hBAP, prohibitin 2, Prohibitin-2
شناسه‌های بیرونی	OMIM: 610704 MGI: 102520 HomoloGene: 5263 GeneCards: PHB2
Gene location (Mouse) Chr. Chromosome 6 (mouse)[1] Band 6 F2|6 59.17 cM Start 124,712,336 bp[1] End 124,716,950 bp[1]
هستی‌شناسی ژن عملکرد ملکولی • protein N-terminus binding • amide binding • protein C-terminus binding • GO:0001948 پیوند پروتئینی • estrogen receptor binding • sphingolipid binding ترکیبات سلولی • سیتوپلاسم • membrane • ماتریکس هسته ای • cell surface • mitochondrial outer membrane • میتوکندری • extracellular exosome • هسته یاخته • cell periphery • mitochondrial inner membrane • آسه • GO:0097483، GO:0097481 postsynaptic density • protein-containing complex • presynaptic active zone • glutamatergic synapse • GABA-ergic synapse فرایند زیستی • regulation of transcription, DNA-templated • mammary gland branching involved in thelarche • protein stabilization • regulation of branching involved in mammary gland duct morphogenesis • mitochondrion organization • negative regulation of mammary gland epithelial cell proliferation • positive regulation of DNA-binding transcription factor activity • positive regulation of exit from mitosis • mammary gland alveolus development • negative regulation of DNA-binding transcription factor activity • transcription, DNA-templated • sister chromatid cohesion • positive regulation of cell cycle G1/S phase transition • positive regulation of ERK1 and ERK2 cascade • negative regulation of transcription, DNA-templated • negative regulation of intracellular estrogen receptor signaling pathway • regulation of complement activation • mitochondrial calcium ion transmembrane transport • response to wounding • negative regulation of apoptotic process • cellular response to retinoic acid • cellular response to hypoxia • protein import into nucleus • regulation of cytochrome-c oxidase activity Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	11331	12034
آنسامبل	ENSG00000215021	ENSMUSG00000004264
یونی‌پروت	Q99623	O35129
RefSeq (mRNA)	NM_001144831، NM_001267700 XR_242980، NM_001144831، NM_001267700	NM_007531
RefSeq (پروتئین)	NP_001254629 NP_001138303، NP_001254629	NP_031557
موقعیت (UCSC)	n/a	Chr : 124.71 – 124.72 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

این پروتئین با PTMA تعامل پروتئین-پروتئین دارد.[7]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000004264 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Coates PJ, Nenutil R, McGregor A, Picksley SM, Crouch DH, Hall PA, Wright EG (Apr 2001). "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence". Exp Cell Res. 265 (2): 262–73. doi:10.1006/excr.2001.5166. PMID 11302691.
5. Coates PJ, Jamieson DJ, Smart K, Prescott AR, Hall PA (Oct 1997). "The prohibitin family of mitochondrial proteins regulate replicative lifespan". Curr Biol. 7 (8): 607–10. doi:10.1016/S0960-9822(06)00261-2. PMID 9259555.
6. "Entrez Gene: PHB2 prohibitin 2".
7. Martini, Paolo G V; Katzenellenbogen Benita S (Jun 2003). "Modulation of estrogen receptor activity by selective coregulators". J. Steroid Biochem. Mol. Biol. 85 (2–5): 117–22. doi:10.1016/S0960-0760(03)00207-3. ISSN 0960-0760. PMID 12943695.

• مشارکت‌کنندگان ویکی‌پدیا. «PHB2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۷ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

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• Martini PG, Delage-Mourroux R, Kraichely DM, Katzenellenbogen BS (2000). "Prothymosin Alpha Selectively Enhances Estrogen Receptor Transcriptional Activity by Interacting with a Repressor of Estrogen Receptor Activity". Mol. Cell. Biol. 20 (17): 6224–32. doi:10.1128/MCB.20.17.6224-6232.2000. PMC 86097. PMID 10938099.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Kurtev V, Margueron R, Kroboth K, et al. (2004). "Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases". J. Biol. Chem. 279 (23): 24834–43. doi:10.1074/jbc.M312300200. PMID 15140878.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
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• Kasashima K, Ohta E, Kagawa Y, Endo H (2007). "Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2". J. Biol. Chem. 281 (47): 36401–10. doi:10.1074/jbc.M605260200. PMID 17008324.
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• Takata H, Matsunaga S, Morimoto A, et al. (2007). "PHB2 protects sister-chromatid cohesion in mitosis". Curr. Biol. 17 (15): 1356–61. doi:10.1016/j.cub.2007.07.009. PMID 17656096.