PLAG1

پروتئین انگشت روی PLAG1 (انگلیسی: Zinc finger protein PLAG1‎) یک پروتئین است که در انسان توسط ژن «PLAG1» کُدگذاری می‌شود.[4][5]

PLAG1
معین‌کننده‌ها
نام‌های دیگرPLAG1, PSA, SGPA, ZNF912, PLAG1 zinc finger, SRS4
شناسه‌های بیرونیOMIM: 603026 MGI: 1891916 HomoloGene: 1993 GeneCards: PLAG1
الگوی گسترش RNA
More reference expression data
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

5324

56711

آنسامبل

ENSG00000181690

ENSMUSG00000003282

یونی‌پروت

Q6DJT9

Q9QYE0

RefSeq (mRNA)

NM_001114634، NM_001114635، NM_002655، XM_017013576، XM_017013577 XM_011517544، NM_001114634، NM_001114635، NM_002655، XM_017013576، XM_017013577

XM_006538116، XM_006538120، XM_006538121، XM_006538122، XM_011250079، XM_017320330، XM_017320331 NM_019969، XM_006538116، XM_006538120، XM_006538121، XM_006538122، XM_011250079، XM_017320330، XM_017320331

RefSeq (پروتئین)

NP_001108107، NP_002646، XP_011515846، XP_016869065، XP_016869066 NP_001108106، NP_001108107، NP_002646، XP_011515846، XP_016869065، XP_016869066

XP_006538179، XP_006538185، XP_017175820، XP_036020162، XP_036020163، XP_036020164، XP_036020165، XP_036020166 NP_064353، XP_006538179، XP_006538185، XP_017175820، XP_036020162، XP_036020163، XP_036020164، XP_036020165، XP_036020166

موقعیت (UCSC)n/aChr : 3.9 – 3.94 Mb
جستجوی PubMed[2][3]
ویکی‌داده
مشاهده/ویرایش HumanView/Edit Mouse

جابه‌جایی کروموزومی آینه‌ای میان کروموزوم‌های ۸ و ۱۲ سبب تشدید بیان این آنزیم در آدنوم چندشکلی غدد بزاقی می‌گردد.[5]

پروتئین PLAG1 با مولکول KPNA2، تعامل پروتئین-پروتئین دارد.[6]

منابع
  1. GRCm38: Ensembl release 89: ENSMUSG00000003282 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Kas K, Röijer E, Voz M, Meyen E, Stenman G, Van de Ven WJ (Nov 1997). "A 2-Mb YAC contig and physical map covering the chromosome 8q12 breakpoint cluster region in pleomorphic adenomas of the salivary glands". Genomics. 43 (3): 349–58. doi:10.1006/geno.1997.4819. PMID 9268638.
  5. "Entrez Gene: PLAG1 pleiomorphic adenoma gene 1".
  6. Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML (May 2002). "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal". J. Biol. Chem. 277 (22): 19673–8. doi:10.1074/jbc.M112112200. PMID 11882654.

برای مطالعهٔ بیشتر
  • Van Dyck F, Declercq J, Braem CV, Van de Ven WJ (2007). "PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review)". Int. J. Oncol. 30 (4): 765–74. doi:10.3892/ijo.30.4.765. PMID 17332914.
  • Kas K, Voz ML, Röijer E, Aström AK, Meyen E, Stenman G, Van de Ven WJ (1997). "Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations". Nat. Genet. 15 (2): 170–4. doi:10.1038/ng0297-170. PMID 9020842.
  • Voz ML, Aström AK, Kas K, Mark J, Stenman G, Van de Ven WJ (1998). "The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter". Oncogene. 16 (11): 1409–16. doi:10.1038/sj.onc.1201660. PMID 9525740.
  • Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
  • Aström AK, Voz ML, Kas K, Röijer E, Wedell B, Mandahl N, Van de Ven W, Mark J, Stenman G (1999). "Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene". Cancer Res. 59 (4): 918–23. PMID 10029085.
  • Voz ML, Agten NS, Van de Ven WJ, Kas K (2000). "PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II". Cancer Res. 60 (1): 106–13. PMID 10646861.
  • Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML (2002). "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal". J. Biol. Chem. 277 (22): 19673–8. doi:10.1074/jbc.M112112200. PMID 11882654.
  • Hensen K, Van Valckenborgh IC, Kas K, Van de Ven WJ, Voz ML (2002). "The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities". Cancer Res. 62 (5): 1510–7. PMID 11888928.
  • Enlund F, Nordkvist A, Sahlin P, Mark J, Stenman G (2002). "Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas". Int. J. Oncol. 20 (4): 713–6. doi:10.3892/ijo.20.4.713. PMID 11894114.
  • Zatkova A, Rouillard JM, Hartmann W, Lamb BJ, Kuick R, Eckart M, von Schweinitz D, Koch A, Fonatsch C, Pietsch T, Hanash SM, Wimmer K (2004). "Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma". Genes Chromosomes Cancer. 39 (2): 126–37. doi:10.1002/gcc.10307. PMID 14695992.
  • Van Dyck F, Delvaux EL, Van de Ven WJ, Chavez MV (2004). "Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation". J. Biol. Chem. 279 (34): 36121–31. doi:10.1074/jbc.M401753200. PMID 15208321.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Tsang YT, Chang YM, Lu X, Rao PH, Lau CC, Wong KK (2004). "Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification". Cancer Genet. Cytogenet. 152 (2): 124–8. doi:10.1016/j.cancergencyto.2003.12.001. PMID 15262430.
  • Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH (2005). "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11". Blood. 105 (7): 2900–7. doi:10.1182/blood-2004-09-3630. PMID 15585652.
  • Morerio C, Rapella A, Rosanda C, Tassano E, Gambini C, Romagnoli G, Panarello C (2005). "PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement". Cancer Genet. Cytogenet. 156 (2): 183–4. doi:10.1016/j.cancergencyto.2004.04.017. PMID 15642402.
  • Martins C, Fonseca I, Roque L, Pereira T, Ribeiro C, Bullerdiek J, Soares J (2005). "PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry". Mod. Pathol. 18 (8): 1048–55. doi:10.1038/modpathol.3800386. PMID 15920557.
  • Declercq J, Van Dyck F, Braem CV, Van Valckenborgh IC, Voz M, Wassef M, Schoonjans L, Van Damme B, Fiette L, Van de Ven WJ (2005). "Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression". Cancer Res. 65 (11): 4544–53. doi:10.1158/0008-5472.CAN-04-4041. PMID 15930271.
  • Zhao X, Ren W, Yang W, Wang Y, Kong H, Wang L, Yan L, Xu G, Fei J, Fu J, Zhang C, Wang Z (2006). "Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice". Int. J. Cancer. 118 (3): 643–8. doi:10.1002/ijc.21400. PMID 16108035.

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