PRDX2

پروکسی‌ردوکسین ۲ (انگلیسی: Peroxiredoxin-2‎) یک پروتئین است که در انسان توسط ژن «PRDX2» کُدگذاری می‌شود.[4][5] این آنزیم یکی از اعضای خانوادهٔ آنزیم‌های آنتی‌اکسیدانی پروکسی‌ردوکسین است.

PRDX2
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 1QMV
معین‌کننده‌ها
نام‌های دیگر	PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxiredoxin 2
شناسه‌های بیرونی	OMIM: 600538 MGI: 109486 HomoloGene: 21182 GeneCards: PRDX2
Gene location (Mouse) Chr. Chromosome 8 (mouse)[1] Band 8 C3|8 41.4 cM Start 84,969,587 bp[1] End 84,974,834 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • oxidoreductase activity • antioxidant activity • peroxiredoxin activity • peroxidase activity • GO:0001948 پیوند پروتئینی • thioredoxin peroxidase activity ترکیبات سلولی • سیتوپلاسم • extracellular exosome • سیتوزول فرایند زیستی • regulation of apoptotic process • negative regulation of apoptotic process • hydrogen peroxide catabolic process • cell redox homeostasis • response to oxidative stress • cellular response to oxidative stress • removal of superoxide radicals • activation of MAPK activity • respiratory burst involved in inflammatory response • regulation of hydrogen peroxide metabolic process • positive regulation of blood coagulation • negative regulation of lipopolysaccharide-mediated signaling pathway • negative regulation of NF-kappaB transcription factor activity • response to lipopolysaccharide • T cell proliferation • hydrogen peroxide metabolic process • negative regulation of T cell differentiation • thymus development • homeostasis of number of cells • negative regulation of reactive oxygen species metabolic process • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • leukocyte activation Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	7001	21672
آنسامبل	ENSG00000167815	ENSMUSG00000005161
یونی‌پروت	P32119	Q61171
RefSeq (mRNA)	NM_005809، NM_181737 NM_181738، NM_005809، NM_181737	NM_001317385 NM_011563، NM_001317385
RefSeq (پروتئین)	NP_005800	NP_035693 NP_001304314، NP_035693
موقعیت (UCSC)	n/a	Chr : 84.97 – 84.97 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

این پروتئین خواص محافظت‌کنندهٔ آنتی‌اکسیدانی دارد و احتمالاً در فعالیت‌های ضد ویروسی لنفوسیت تی کشنده نیز مشارکت دارد. همچنین این پروتئین خواص تحریک‌کنندگی در زمینهٔ زایش و تکثیر سلولی دارد و به‌همین دلیل، ممکن است در بروز و پیشرفت سرطان نقش داشته باشد. چندین نسخهٔ رونویسی گوناگون از این ژن که ایزوفرم‌های پروتئینی متفاوتی را می‌سازند، تاکنون کشف شده‌است.[5]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000005161 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Pahl P, Berger R, Hart I, Chae HZ, Rhee SG, Patterson D (Aug 1995). "Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12". Genomics. 26 (3): 602–6. doi:10.1016/0888-7543(95)80183-M. PMID 7607688.
5. "Entrez Gene: PRDX2 peroxiredoxin 2".

• مشارکت‌کنندگان ویکی‌پدیا. «Peroxiredoxin 2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۶ آوریل ۲۰۱۸.

بیشتر بخوانید

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