SIN3A

پروتئین مارپیچ آمفی‌پاتیک مزدوج Sin3a (انگلیسی: Paired amphipathic helix protein Sin3a‎) یک پروتئین است که در انسان توسط ژن «SIN3A» کُدگذاری می‌شود.[4][5]

SIN3A
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 1PO4
معین‌کننده‌ها
نام‌های دیگر	SIN3A, Paired amphipathic helix protein Sin3a, SIN3 transcription regulator family member A, WITKOS
شناسه‌های بیرونی	OMIM: 607776 MGI: 107157 HomoloGene: 32124 GeneCards: SIN3A
Gene location (Mouse) Chr. Chromosome 9 (mouse)[1] Band 9 B|9 30.89 cM Start 57,072,040 bp[1] End 57,128,366 bp[1]
هستی‌شناسی ژن عملکرد ملکولی • DNA binding • GO:0001106 transcription corepressor activity • histone deacetylase activity • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity • protein deacetylase activity • transcription factor binding • chromatin binding • GO:0000975 transcription cis-regulatory region binding • GO:0001948 پیوند پروتئینی • RNA binding • GO:0032403 protein-containing complex binding ترکیبات سلولی • transcription regulator complex • transcription repressor complex • نوکلئوپلاسم • هستک • کروماتین • هسته یاخته • کینه توکور • Sin3 complex • protein-containing complex فرایند زیستی • negative regulation of protein localization to nucleus • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • rhythmic process • cellular response to dopamine • response to methylglyoxal • negative regulation of circadian rhythm • regulation of hormone levels • پیرش • negative regulation of apoptotic process • in utero embryonic development • negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • protein deacetylation • همانندسازی • cellular protein localization • negative regulation of transcription regulatory region DNA binding • response to organonitrogen compound • hematopoietic progenitor cell differentiation • activation of innate immune response • positive regulation of G2/M transition of mitotic cell cycle • negative regulation of transcription, DNA-templated • histone deacetylation • positive regulation of chromatin silencing • negative regulation of histone H3-K27 acetylation • cellular response to glucose stimulus • positive regulation of transcription by RNA polymerase II • positive regulation of defense response to virus by host • regulation of lipid metabolic process • regulation of megakaryocyte differentiation • negative regulation of nucleic acid-templated transcription Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	25942	20466
آنسامبل	ENSG00000169375	ENSMUSG00000042557
یونی‌پروت	Q96ST3	Q60520
RefSeq (mRNA)	NM_001145357، NM_001145358، NM_015477، XM_006720465، XM_006720466، XM_024449896 XM_006720467، NM_001145357، NM_001145358، NM_015477، XM_006720465، XM_006720466، XM_024449896	NM_001110351، NM_011378، XM_006510890، XM_006510891، XM_006510892، XM_006510893، XM_011242683، XM_011242684، XM_011242685، XM_011242686، NM_001357754، XM_030244150 NM_001110350، NM_001110351، NM_011378، XM_006510890، XM_006510891، XM_006510892، XM_006510893، XM_011242683، XM_011242684، XM_011242685، XM_011242686، NM_001357754، XM_030244150
RefSeq (پروتئین)	NP_001138830، NP_056292، XP_006720528، XP_006720529، XP_006720530، XP_024305664 NP_001138829، NP_001138830، NP_056292، XP_006720528، XP_006720529، XP_006720530، XP_024305664	NP_001103821، NP_035508، XP_006510953، XP_006510954، XP_006510955، XP_006510956، XP_011240985، XP_011240986، XP_011240987، XP_011240988، NP_001344683، XP_030100010، XP_036010639، XP_036010640، XP_036010641 NP_001103820، NP_001103821، NP_035508، XP_006510953، XP_006510954، XP_006510955، XP_006510956، XP_011240985، XP_011240986، XP_011240987، XP_011240988، NP_001344683، XP_030100010، XP_036010639، XP_036010640، XP_036010641
موقعیت (UCSC)	n/a	Chr : 57.07 – 57.13 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

این مولکول، یک پروتئینِ تنظیم‌کنندهٔ رونویسی ژنتیکی است.

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000042557 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Yu F, Thiesen J, Strätling WH (May 2000). "Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2". Nucleic Acids Research. 28 (10): 2201–6. doi:10.1093/nar/28.10.2201. PMC 105362. PMID 10773092.
5. Halleck MS, Pownall S, Harder KW, Duncan AM, Jirik FR, Schlegel RA (March 1995). "A widely distributed putative mammalian transcriptional regulator containing multiple paired amphipathic helices, with similarity to yeast SIN3". Genomics. 26 (2): 403–6. doi:10.1016/0888-7543(95)80229-F. PMID 7601471.

• مشارکت‌کنندگان ویکی‌پدیا. «SIN3A». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر

• Zhang Y, Dufau ML (June 2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". The Journal of Steroid Biochemistry and Molecular Biology. 85 (2–5): 401–14. doi:10.1016/S0960-0760(03)00230-9. PMID 12943729.
• Ayer DE, Lawrence QA, Eisenman RN (March 1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3". Cell. 80 (5): 767–76. doi:10.1016/0092-8674(95)90355-0. PMID 7889570.
• Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". The EMBO Journal. 14 (22): 5646–59. PMC 394680. PMID 8521822.
• Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE (May 1997). "Histone deacetylase activity is required for full transcriptional repression by mSin3A". Cell. 89 (3): 341–7. doi:10.1016/S0092-8674(00)80214-7. PMID 9150133.
• Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (May 1997). "Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression". Cell. 89 (3): 349–56. doi:10.1016/S0092-8674(00)80215-9. PMID 9150134.
• Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. PMID 9150135.
• Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.
• Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM (February 1998). "Role of the histone deacetylase complex in acute promyelocytic leukaemia". Nature. 391 (6669): 811–4. doi:10.1038/35895. PMID 9486654.
• David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.
• Wong CW, Privalsky ML (October 1998). "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". The Journal of Biological Chemistry. 273 (42): 27695–702. doi:10.1074/jbc.273.42.27695. PMID 9765306.
• Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D (October 1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities". Cell. 95 (2): 279–89. doi:10.1016/S0092-8674(00)81758-4. PMID 9790534.
• Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (October 1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature. 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427.
• Koipally J, Renold A, Kim J, Georgopoulos K (June 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
• Boutell JM, Thomas P, Neal JW, Weston VJ, Duce J, Harper PS, Jones AL (September 1999). "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Human Molecular Genetics. 8 (9): 1647–55. doi:10.1093/hmg/8.9.1647. PMID 10441327.
• Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (August 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.
• Kao HY, Downes M, Ordentlich P, Evans RM (January 2000). "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression". Genes & Development. 14 (1): 55–66. doi:10.1101/gad.14.1.55. PMC 316336. PMID 10640276.
• Huang S, Brandt SJ (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Molecular and Cellular Biology. 20 (6): 2248–59. doi:10.1128/MCB.20.6.2248-2259.2000. PMC 110841. PMID 10688671.
• Koipally J, Georgopoulos K (June 2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity". The Journal of Biological Chemistry. 275 (26): 19594–602. doi:10.1074/jbc.M000254200. PMID 10766745.

پیوند به بیرون

• SIN3A protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
• Sin3Ak-20 در دانشنامهٔ اجزای دی‌ان‌ای