سایکلین دی۱

سایکلین دی۱ (انگلیسی: Cyclin D1‎) یک پروتئین است که در انسان توسط ژن «CCND1» کُدگذاری می‌شود. ژن مذکور بر روی بازوی بلند کروموزوم ۱۱ (باند 11q13) واقع است و در حدود ۱۳٬۳۸۸ جفت باز طول دارد و ۲۹۵ پروتئین را کُدگذاری می‌کند.[4][5]

CCND1
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 2W96, 2W99, 2W9F, 2W9Z
معین‌کننده‌ها
نام‌های دیگر	CCND1, BCL1, D11S287E, PRAD1, U21B31, cyclin D1
شناسه‌های بیرونی	OMIM: 168461 MGI: 88313 HomoloGene: 1334 GeneCards: CCND1
Gene location (Mouse) Chr. Chromosome 7 (mouse)[1] Band 7 F5|7 88.92 cM Start 144,929,931 bp[1] End 144,939,925 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • protein kinase activity • GO:0001106 transcription corepressor activity • transcription factor binding • histone deacetylase binding • kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity • GO:0001948 پیوند پروتئینی • enzyme binding • proline-rich region binding • protein kinase binding • cyclin-dependent protein serine/threonine kinase activity • GO:0032403 protein-containing complex binding ترکیبات سلولی • سیتوپلاسم • سیتوزول • cyclin-dependent protein kinase holoenzyme complex • membrane • bicellular tight junction • transcription repressor complex • intracellular anatomical structure • نوکلئوپلاسم • هسته یاخته فرایند زیستی • cellular response to organic substance • mammary gland epithelial cell proliferation • positive regulation of mammary gland epithelial cell proliferation • response to estradiol • positive regulation of protein phosphorylation • Leydig cell differentiation • regulation of transcription, DNA-templated • response to organic cyclic compound • response to steroid hormone • response to corticosterone • negative regulation of Wnt signaling pathway • response to magnesium ion • response to glucocorticoid • re-entry into mitotic cell cycle • negative regulation of transcription by RNA polymerase II • Wnt signaling pathway • mammary gland alveolus development • response to organic substance • transcription, DNA-templated • response to vitamin E • regulation of cell cycle • response to iron ion • response to estrogen • response to calcium ion • تقسیم یاخته • cellular response to DNA damage stimulus • endoplasmic reticulum unfolded protein response • protein phosphorylation • regulation of G1/S transition of mitotic cell cycle • liver regeneration • mitotic G1 DNA damage checkpoint signaling • animal organ regeneration • response to organonitrogen compound • positive regulation of cell population proliferation • positive regulation of cyclin-dependent protein serine/threonine kinase activity • canonical Wnt signaling pathway • response to UV-A • چرخه یاخته‌ای • liver development • positive regulation of G2/M transition of mitotic cell cycle • lactation • response to ethanol • response to leptin • negative regulation of epithelial cell differentiation • fat cell differentiation • response to X-ray • response to drug • positive regulation of cell cycle • transcription initiation from RNA polymerase II promoter • G1/S transition of mitotic cell cycle • cytokine-mediated signaling pathway • positive regulation of epithelial cell proliferation • regulation of cyclin-dependent protein serine/threonine kinase activity • GO:0007067 رشتمان • regulation of mitotic nuclear division • positive regulation of G1/S transition of mitotic cell cycle Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	595	12443
آنسامبل	ENSG00000110092	ENSMUSG00000070348
یونی‌پروت	P24385	P25322
RefSeq (mRNA)	NM_053056	XM_011241977، NM_001379248 NM_007631، XM_011241977، NM_001379248
RefSeq (پروتئین)	NP_444284	NP_001366177 NP_031657، NP_001366177
موقعیت (UCSC)	n/a	Chr : 144.93 – 144.94 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

اهمیت بالینی

تولید بیش از حد این پروتئین در مراحل آغازین سرطان و پیشرفت تومور مشاهده شده‌است[6] و می‌تواند از طریق رشد بدون حمایت تکیه‌گاه سلولی و همچنین رگ‌سازی وابسته به تولید فاکتور رشد اندوتلیال عروقی، منجر به سرطان‌زایی شود.[7] تولید زیاد این سایکلین دی۱ همچنین سبب کاهش بیان ژنی Fas شده و در نتیجه مقاوت به شیمی‌درمانی پیش می‌آید و سلول‌های سرطانی در برابر آپوپتوز محافظت می‌شوند.[7]

تولید بیش از حد این پروتئین با بقای کمتر بیماران سرطانی و افزایش متاستاز در ارتباط است.[8][9] چنین افزایشی در میزانِ این پروتئین در سرطان‌های زیر یافت شده‌است:

• سرطان ریه از نوع سلول غیر کوچک (۳۰–۴۶٪)[10][11]
• سرطان‌های بافت پوششی سر و گردن (۳۰–۵۰٪)[12][13][14]
• سرطان لوزالمعده (۲۵٪)[15]
• سرطان مثانه (۱۵٪)[16]
• آدنوم هیپوفیز (۴۹–۵۴٪)[17][18]
• سرطان پستان(۱۳٪)[19][20][21]

بیش‌تولیدی سایکلین دی۱ به‌ویژه در «سرطان‌های پستان نوع ER+» قویاً تأیید شده‌است[21] و عدم تنظیم آن با بروز مقاومت به هورمون‌درمانی در این سرطان‌ها مرتبط است.[22][23][24]

جابه‌جایی کروموزومی جایگاه ژنی سایکلین دی۱ در حدود ۱۵ – ۲۰٪ از موارد مولتیپل میلوما یافت شده‌است.[25][26]

از روش‌های رنگ‌آمیزی ایمونوهیستوشیمی آنتی‌بادی‌های سایکلین دی۱ برای تشخیص لنفوم سلول منتل استفاده می‌شود. همچنین پیشنهاد شده تا از آن به‌عنوان یک نشانگر زیستی برای تشخیص سرطان پستان استفاده شود.[27]

جستارهای وابسته

• لنفوم سلول منتل

منابع

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• مشارکت‌کنندگان ویکی‌پدیا. «Cyclin D1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ ژوئن ۲۰۱۹.

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