پروتئین ۴ ریخت‌زایی استخوان

BMP4
معین‌کننده‌ها
نام‌های دیگر	BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4
شناسه‌های بیرونی	OMIM: 112262 MGI: 88180 HomoloGene: 7247 GeneCards: BMP4
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[1]
End	46,390,669 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• heparin binding; • cytokine activity; • co-receptor binding; • transforming growth factor beta receptor binding; • growth factor activity; • BMP receptor binding; • GO:0001948 پیوند پروتئینی; • chemoattractant activity;
ترکیبات سلولی	• extracellular region; • extracellular space; • endoplasmic reticulum lumen;
فرایند زیستی	• embryonic skeletal system morphogenesis; • negative regulation of T cell differentiation in thymus; • germ cell development; • skeletal system development; • mesenchymal cell differentiation involved in renal system development; • cardiac septum development; • ureteric bud development; • positive regulation of protein phosphorylation; • renal system process; • positive regulation of endothelial cell differentiation; • negative regulation of immature T cell proliferation in thymus; • bud elongation involved in lung branching; • tendon cell differentiation; • anatomical structure formation involved in morphogenesis; • ureter epithelial cell differentiation; • negative regulation of cell cycle; • mesenchymal to epithelial transition involved in metanephros morphogenesis; • trachea development; • post-embryonic development; • monocyte differentiation; • specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; • blood vessel endothelial cell proliferation involved in sprouting angiogenesis; • BMP signaling pathway involved in renal system segmentation; • cranial suture morphogenesis; • mesonephros development; • odontogenesis of dentin-containing tooth; • telencephalon regionalization; • negative regulation of chondrocyte differentiation; • blood vessel development; • negative regulation of mitotic nuclear division; • رگ‌زایی; • prostate gland morphogenesis; • positive regulation of ERK1 and ERK2 cascade; • smooth muscle tissue development; • BMP signaling pathway involved in heart induction; • negative regulation of epithelial cell proliferation; • بافت زایی; • metanephric collecting duct development; • inner ear receptor cell differentiation; • mesodermal cell fate determination; • metanephros development; • type B pancreatic cell development; • regulation of pathway-restricted SMAD protein phosphorylation; • negative regulation of cell population proliferation; • steroid hormone mediated signaling pathway; • mammary gland formation; • positive regulation of collagen biosynthetic process; • renal system development; • negative regulation of myoblast differentiation; • cell fate commitment; • common-partner SMAD protein phosphorylation; • glomerular visceral epithelial cell development; • SMAD protein signal transduction; • استخوان‌سازی; • activation of MAPKK activity; • kidney development; • lung development; • ureter smooth muscle cell differentiation; • embryonic digit morphogenesis; • epithelial-mesenchymal cell signaling; • negative regulation of thymocyte apoptotic process; • mesenchymal cell differentiation involved in kidney development; • negative regulation of cell death; • regulation of odontogenesis of dentin-containing tooth; • BMP signaling pathway involved in ureter morphogenesis; • mesenchymal cell proliferation involved in ureteric bud development; • smooth muscle cell differentiation; • lymphoid progenitor cell differentiation; • epithelium development; • positive regulation of transcription, DNA-templated; • deltoid tuberosity development; • negative regulation of prostatic bud formation; • heart development; • telencephalon development; • branching involved in ureteric bud morphogenesis; • positive regulation of kidney development; • cartilage development; • embryonic limb morphogenesis; • مپ کیناز; • positive regulation of cartilage development; • lens induction in camera-type eye; • positive regulation of neuron differentiation; • branching involved in prostate gland morphogenesis; • regulation of protein import into nucleus; • positive regulation of cell differentiation; • erythrocyte differentiation; • smoothened signaling pathway; • camera-type eye development; • secondary heart field specification; • negative regulation of phosphorylation; • regulation of smooth muscle cell differentiation; • regulation of cell fate commitment; • regulation of branching involved in prostate gland morphogenesis; • دگرگونی یاخته‌; • positive regulation of branching involved in lung morphogenesis; • chondrocyte differentiation; • regulation of cartilage development; • organ induction; • positive regulation of epithelial cell proliferation; • epithelial cell proliferation involved in lung morphogenesis; • negative regulation of cell proliferation involved in heart morphogenesis; • negative regulation of apoptotic process; • positive regulation of ossification; • استخوان‌سازی درون‌غضروفی; • regulation of smooth muscle cell proliferation; • regulation of morphogenesis of a branching structure; • BMP signaling pathway; • macrophage differentiation; • negative regulation of metanephric comma-shaped body morphogenesis; • embryonic skeletal system development; • mesenchymal cell proliferation involved in ureter development; • osteoblast differentiation; • hematopoietic progenitor cell differentiation; • positive regulation of BMP signaling pathway; • ساماندهی بیان ژن; • embryonic cranial skeleton morphogenesis; • dorsal/ventral neural tube patterning; • lung alveolus development; • positive regulation of protein binding; • anterior/posterior axis specification; • negative regulation of transcription, DNA-templated; • positive regulation of epidermal cell differentiation; • branching morphogenesis of an epithelial tube; • trachea formation; • specification of animal organ position; • negative regulation of glomerular mesangial cell proliferation; • positive regulation of smooth muscle cell proliferation; • intermediate mesodermal cell differentiation; • pulmonary artery endothelial tube morphogenesis; • pituitary gland development; • positive regulation of cell death; • lung morphogenesis; • positive regulation of endothelial cell proliferation; • bud dilation involved in lung branching; • positive regulation of cardiac muscle fiber development; • negative regulation of striated muscle tissue development; • positive regulation of cell migration; • negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; • BMP signaling pathway involved in nephric duct formation; • positive regulation of pathway-restricted SMAD protein phosphorylation; • negative regulation of mesenchymal cell proliferation involved in ureter development; • mesoderm formation; • cellular response to growth factor stimulus; • glomerular capillary formation; • bronchus development; • positive regulation of endothelial cell migration; • multicellular organism development; • negative regulation of metanephric S-shaped body morphogenesis; • neural tube closure; • vasculature development; • embryonic morphogenesis; • protein localization to nucleus; • positive regulation of apoptotic process; • embryonic skeletal joint morphogenesis; • regulation of cell differentiation; • negative regulation of branching involved in ureteric bud morphogenesis; • mesodermal cell differentiation; • neuron fate commitment; • forebrain development; • cloacal septation; • bone development; • camera-type eye morphogenesis; • positive regulation of SMAD protein signal transduction; • negative regulation of glomerulus development; • embryonic hindlimb morphogenesis; • positive chemotaxis; • outflow tract morphogenesis; • odontogenesis; • negative regulation of transcription by RNA polymerase II; • epithelial to mesenchymal transition involved in endocardial cushion formation; • cardiac jelly development; • cellular response to BMP stimulus; • positive regulation of osteoblast differentiation; • epithelial tube branching involved in lung morphogenesis; • cardiac muscle cell differentiation; • apoptotic process involved in endocardial cushion morphogenesis; • muscular septum morphogenesis; • positive regulation of transcription by RNA polymerase II; • positive regulation of bone mineralization; • cardiac right ventricle morphogenesis; • outflow tract septum morphogenesis; • membranous septum morphogenesis; • aortic valve morphogenesis; • pulmonary valve morphogenesis; • endocardial cushion development; • endoderm development; • coronary vasculature development; • BMP signaling pathway involved in heart development; • pharyngeal arch artery morphogenesis; • positive regulation of cell proliferation involved in outflow tract morphogenesis; • negative regulation of extrinsic apoptotic signaling pathway; • regulation of pri-miRNA transcription by RNA polymerase II; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • پیرایش پسارونویسی; • cellular protein metabolic process; • positive regulation of gene expression; • positive regulation of epithelial to mesenchymal transition; • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; • regulation of signaling receptor activity; • positive regulation of cell population proliferation; • negative regulation of gene expression; • negative regulation of pri-miRNA transcription by RNA polymerase II; • regulation of apoptotic process; • regulation of MAPK cascade; • cell development; • growth;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	652
	12159
	ENSG00000125378
	ENSMUSG00000021835
	P12644
	P21275
	NM_001202، NM_130850، NM_130851، XM_017021603، XM_017021604، XM_017021605 XM_005268015، NM_001202، NM_130850، NM_130851، XM_017021603، XM_017021604، XM_017021605
	NM_001316360 NM_007554، NM_001316360
	NP_570911، NP_001334841، NP_001334842، NP_001334843، NP_001334844، NP_001334845، NP_001334846، NP_570912 NP_001193، NP_570911، NP_001334841، NP_001334842، NP_001334843، NP_001334844، NP_001334845، NP_001334846، NP_570912
	NP_031580 NP_001303289، NP_031580
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین شمارهٔ ۴ ریخت‌زایی استخوان (انگلیسی: Bone morphogenetic protein 4‎) پروتئینی است که در انسان توسط ژن «BMP4» کُد می‌شود.[4][5] این ژن بر روی بازوی بلند کروموزوم ۱۴ واقع است.

این مولکول حیاتی در مراحل اولیه رشد و تکامل جنینی در ناحیه چشم‌ها، قلب و کیسهٔ شنوایی وجود دارد.[6]

این پروتئین با بروز برخی از بیماری‌های استخوانی از جمله «فیبرودیسپلازی استخوانی‌شونده پیشرونده» در ارتباط است[7] و احتمالاً در بروز لب‌شکری هم نقش دارد.[8]

از دیگر نقش‌های مهم این پروتئین می‌توان به رشد و تکامل چشم‌ها و همچنین ریزش مو و کچلی اشاره کرد.

منابع

GRCm38: Ensembl release 89: ENSMUSG00000021835 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
van den Wijngaard A, Weghuis DO, Boersma CJ, van Zoelen EJ, Geurts van Kessel A, Olijve W (November 1995). "Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization". Genomics. 27 (3): 559–60. doi:10.1006/geno.1995.1096. PMID 7558046.
Oida S, Iimura T, Maruoka Y, Takeda K, Sasaki S (November 1995). "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library". DNA Seq. 5 (5): 273–5. doi:10.3109/10425179509030980. PMID 7579580.
Knöchel S, Dillinger K, Köster M, Knöchel W (November 2001). "Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes". Mech. Dev. 109 (1): 79–82. doi:10.1016/S0925-4773(01)00506-8. PMID 11677055.
Kan L, Hu M, Gomes WA, Kessler JA (October 2004). "Transgenic Mice Overexpressing BMP4 Develop a Fibrodysplasia Ossificans Progressiva (FOP)-Like Phenotype". Am. J. Pathol. 165 (4): 1107–15. doi:10.1016/S0002-9440(10)63372-X. PMC 1618644. PMID 15466378.
Dixon MJ, Marazita ML, Beaty TH, Murray JC (March 2011). "Cleft lip and palate: understanding genetic and environmental influences". Nat. Rev. Genet. 12 (3): 167–78. doi:10.1038/nrg2933. PMC 3086810. PMID 21331089.

مشارکت‌کنندگان ویکی‌پدیا. «Bone morphogenetic protein 4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ دسامبر ۲۰۱۷.

بیشتر بخوانید

Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA (1989). "Novel regulators of bone formation: molecular clones and activities". Science. 242 (4885): 1528–34. doi:10.1126/science.3201241. PMID 3201241.
Rosenzweig BL, Imamura T, Okadome T, Cox GN, Yamashita H, ten Dijke P, Heldin CH, Miyazono K (1995). "Cloning and characterization of a human type II receptor for bone morphogenetic proteins". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7632–6. doi:10.1073/pnas.92.17.7632. PMC 41199. PMID 7644468.
Nohno T, Ishikawa T, Saito T, Hosokawa K, Noji S, Wolsing DH, Rosenbaum JS (1995). "Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors". J. Biol. Chem. 270 (38): 22522–6. doi:10.1074/jbc.270.38.22522. PMID 7673243.
Yamaji N, Celeste AJ, Thies RS, Song JJ, Bernier SM, Goltzman D, Lyons KM, Nove J, Rosen V, Wozney JM (1995). "A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4". Biochem. Biophys. Res. Commun. 205 (3): 1944–51. doi:10.1006/bbrc.1994.2898. PMID 7811286.
Harris SE, Harris MA, Mahy P, Wozney J, Feng JQ, Mundy GR (1994). "Expression of bone morphogenetic protein messenger RNAs by normal rat and human prostate and prostate cancer cells". Prostate. 24 (4): 204–11. doi:10.1002/pros.2990240406. PMID 8146069.
van den Wijngaard A, van Kraay M, van Zoelen EJ, Olijve W, Boersma CJ (1996). "Genomic organization of the human bone morphogenetic protein-4 gene: molecular basis for multiple transcripts". Biochem. Biophys. Res. Commun. 219 (3): 789–94. doi:10.1006/bbrc.1996.0312. PMID 8645259.
Nishitoh H, Ichijo H, Kimura M, Matsumoto T, Makishima F, Yamaguchi A, Yamashita H, Enomoto S, Miyazono K (1996). "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5". J. Biol. Chem. 271 (35): 21345–52. doi:10.1074/jbc.271.35.21345. PMID 8702914.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Shore EM, Xu M, Shah PB, Janoff HB, Hahn GV, Deardorff MA, Sovinsky L, Spinner NB, Zasloff MA, Wozney JM, Kaplan FS (1998). "The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation". Calcif. Tissue Int. 63 (3): 221–9. doi:10.1007/s002239900518. PMID 9701626.
Tucker AS, Matthews KL, Sharpe PT (1998). "Transformation of tooth type induced by inhibition of BMP signaling". Science. 282 (5391): 1136–8. doi:10.1126/science.282.5391.1136. PMID 9804553.
Van den Wijngaard A, Pijpers MA, Joosten PH, Roelofs JM, Van zoelen EJ, Olijve W (1999). "Functional characterization of two promoters in the human bone morphogenetic protein-4 gene". J. Bone Miner. Res. 14 (8): 1432–41. doi:10.1359/jbmr.1999.14.8.1432. PMID 10457277.
Li W, LoTurco JJ (2000). "Noggin is a negative regulator of neuronal differentiation in developing neocortex". Dev. Neurosci. 22 (1–2): 68–73. doi:10.1159/000017428. PMID 10657699.
Raatikainen-Ahokas A, Hytönen M, Tenhunen A, Sainio K, Sariola H (2000). "BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney". Dev. Dyn. 217 (2): 146–58. doi:10.1002/(SICI)1097-0177(200002)217:2<146::AID-DVDY2>3.0.CO;2-I. PMID 10706139.
van den Wijngaard A, Mulder WR, Dijkema R, Boersma CJ, Mosselman S, van Zoelen EJ, Olijve W (2000). "Antiestrogens specifically up-regulate bone morphogenetic protein-4 promoter activity in human osteoblastic cells". Mol. Endocrinol. 14 (5): 623–33. doi:10.1210/me.14.5.623. PMID 10809227.
Ying Y, Liu XM, Marble A, Lawson KA, Zhao GQ (2000). "Requirement of Bmp8b for the generation of primordial germ cells in the mouse". Mol. Endocrinol. 14 (7): 1053–63. doi:10.1210/mend.14.7.0479. PMID 10894154.
Nakade O, Takahashi K, Takuma T, Aoki T, Kaku T (2001). "Effect of extracellular calcium on the gene expression of bone morphogenetic protein-2 and -4 of normal human bone cells". J. Bone Miner. Metab. 19 (1): 13–9. doi:10.1007/s007740170055. PMID 11156467.
Hatta T, Konishi H, Katoh E, Natsume T, Ueno N, Kobayashi Y, Yamazaki T (2001). "Identification of the ligand-binding site of the BMP type IA receptor for BMP-4". Biopolymers. 55 (5): 399–406. doi:10.1002/1097-0282(2000)55:5<399::AID-BIP1014>3.0.CO;2-9. PMID 11241215.
Aoki H, Fujii M, Imamura T, Yagi K, Takehara K, Kato M, Miyazono K (2001). "Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction". J. Cell Sci. 114 (Pt 8): 1483–9. PMID 11282024.
Kalinovsky A, Boukhtouche F, Blazeski R, Bornmann C, Suzuki N, Mason CA, Scheiffele P (2011). Polleux F, ed. "Development of Axon-Target Specificity of Ponto-Cerebellar Afferents". PLoS Biology. 9 (2): e1001013. doi:10.1371/journal.pbio.1001013. PMC 3035609. PMID 21346800.
Cotsarelis G, Millar SE (July 2001). "Towards a molecular understanding of hair loss and its treatment". Trends Mol Med. 7 (7): 293–301. doi:10.1016/S1471-4914(01)02027-5. PMID 11425637.
Feijen A, Goumans MJ, van den Eijnden-van Raaij AJ (December 1994). "Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins". Development. 120 (12): 3621–37. PMID 7821227.
Graham A, Francis-West P, Brickell P, Lumsden A (December 1994). "The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest". Nature. 372 (6507): 684–6. doi:10.1038/372684a0. PMID 7990961.
Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W (May 2001). "beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin". Cell. 105 (4): 533–45. doi:10.1016/S0092-8674(01)00336-1. PMID 11371349.
Kulessa H, Turk G, Hogan BL (December 2000). "Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle". EMBO J. 19 (24): 6664–74. doi:10.1093/emboj/19.24.6664. PMC 305899. PMID 11118201.
Leong LM, Brickell PM (December 1996). "Bone morphogenic protein-4". Int. J. Biochem. Cell Biol. 28 (12): 1293–6. doi:10.1016/S1357-2725(96)00075-1. PMID 9022288.
Liem KF, Tremml G, Roelink H, Jessell TM (September 1995). "Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm". Cell. 82 (6): 969–79. doi:10.1016/0092-8674(95)90276-7. PMID 7553857.
Millar SE (February 2002). "Molecular mechanisms regulating hair follicle development". J. Invest. Dermatol. 118 (2): 216–25. doi:10.1046/j.0022-202x.2001.01670.x. PMID 11841536.
Pourquié O, Fan CM, Coltey M, Hirsinger E, Watanabe Y, Bréant C, Francis-West P, Brickell P, Tessier-Lavigne M, Le Douarin NM (February 1996). "Lateral and axial signals involved in avian somite patterning: a role for BMP4". Cell. 84 (3): 461–71. doi:10.1016/S0092-8674(00)81291-X. PMID 8608600.
Wang EA, Israel DI, Kelly S, Luxenberg DP (1993). "Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells". Growth Factors. 9 (1): 57–71. doi:10.3109/08977199308991582. PMID 8347351.
Winnier G, Blessing M, Labosky PA, Hogan BL (September 1995). "Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse". Genes Dev. 9 (17): 2105–16. doi:10.1101/gad.9.17.2105. PMID 7657163.

پیوند به بیرون

مکان ژن انسانی BMP4 در مرورگر ژنومی UCSC.
جزئیات ژن انسانی BMP4 در مرورگر ژنومی UCSC.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000021835 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7558046-4] van den Wijngaard A, Weghuis DO, Boersma CJ, van Zoelen EJ, Geurts van Kessel A, Olijve W (November 1995). "Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization". Genomics. 27 (3): 559–60. doi:10.1006/geno.1995.1096. PMID 7558046.

[pmid7579580-5] Oida S, Iimura T, Maruoka Y, Takeda K, Sasaki S (November 1995). "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library". DNA Seq. 5 (5): 273–5. doi:10.3109/10425179509030980. PMID 7579580.

[pmid11677055-6] Knöchel S, Dillinger K, Köster M, Knöchel W (November 2001). "Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes". Mech. Dev. 109 (1): 79–82. doi:10.1016/S0925-4773(01)00506-8. PMID 11677055.

[pmid15466378-7] Kan L, Hu M, Gomes WA, Kessler JA (October 2004). "Transgenic Mice Overexpressing BMP4 Develop a Fibrodysplasia Ossificans Progressiva (FOP)-Like Phenotype". Am. J. Pathol. 165 (4): 1107–15. doi:10.1016/S0002-9440(10)63372-X. PMC 1618644. PMID 15466378.

[pmid21331089-8] Dixon MJ, Marazita ML, Beaty TH, Murray JC (March 2011). "Cleft lip and palate: understanding genetic and environmental influences". Nat. Rev. Genet. 12 (3): 167–78. doi:10.1038/nrg2933. PMC 3086810. PMID 21331089.