گلیپیکان ۳

گلیپیکان ۳ (انگلیسی: Glypican 3‎) یک پروتئین است که در انسان توسط ژن «GPC3» کُدگذاری می‌شود.[5][6][7][8] این ژن بر روی بازوی بلندِ کروموزوم ایکس قرار دارد و یک پروتئین ۷۰ کیلو دالتونی را با ۵۸۰ اسید آمینه می‌سازد.[9]

GPC3
معین‌کننده‌ها
نام‌های دیگر	GPC3, DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1, Glypican 3
شناسه‌های بیرونی	OMIM: 300037 MGI: 104903 HomoloGene: 20944 GeneCards: GPC3
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.2 Start 133,535,745 bp[1] End 133,985,594 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A5 Start 52,272,426 bp[2] End 52,613,950 bp[2]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • peptidase inhibitor activity • GO:0001948 پیوند پروتئینی • peptidyl-dipeptidase inhibitor activity • heparan sulfate proteoglycan binding ترکیبات سلولی • membrane • anchored component of plasma membrane • پوسته یاخته • integral component of plasma membrane • extracellular region • lysosomal lumen • Golgi lumen • anchored component of membrane • کافنده‌تن • extracellular space • endoplasmic reticulum lumen • intrinsic component of plasma membrane • collagen-containing extracellular matrix فرایند زیستی • body morphogenesis • positive regulation of glucose import • bone mineralization • negative regulation of peptidase activity • negative regulation of growth • negative regulation of smoothened signaling pathway • positive regulation of protein catabolic process • positive regulation of smoothened signaling pathway • cell proliferation involved in metanephros development • lung development • kidney development • osteoclast differentiation • anatomical structure morphogenesis • mesenchymal cell proliferation involved in ureteric bud development • mesonephric duct morphogenesis • coronary vasculature development • retinoid metabolic process • cell proliferation involved in kidney development • positive regulation of endocytosis • branching involved in ureteric bud morphogenesis • glycosaminoglycan catabolic process • glycosaminoglycan biosynthetic process • negative regulation of epithelial cell proliferation • positive regulation of BMP signaling pathway • animal organ morphogenesis • regulation of growth • positive regulation of Wnt signaling pathway, planar cell polarity pathway • anterior/posterior axis specification • negative regulation of canonical Wnt signaling pathway • negative regulation of cell population proliferation • embryonic hindlimb morphogenesis • پیرایش پسارونویسی • cellular protein metabolic process • regulation of signal transduction • response to bacterium Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	2719	14734
آنسامبل	ENSG00000147257	ENSMUSG00000055653
یونی‌پروت	P51654	Q8CFZ4
RefSeq (mRNA)	NM_001164617، NM_001164618، NM_001164619، XM_017029413 NM_004484، NM_001164617، NM_001164618، NM_001164619، XM_017029413	NM_016697
RefSeq (پروتئین)	NP_001158090، NP_001158091، NP_004475، XP_016884902 NP_001158089، NP_001158090، NP_001158091، NP_004475، XP_016884902 NP_004475.1	NP_057906
موقعیت (UCSC)	Chr X: 133.54 – 133.99 Mb	Chr X: 52.27 – 52.61 Mb
جستجوی PubMed	[3]	[4]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

اهمیت بالینی

جهش در ژن «GPC3» با بروز «سندرم سیمپسون–گلابی–بیمل نوع ۱» در ارتباط است.[10]

از این پروتئین می‌توان در تمایز انواع سرطان‌های کبد با تغییرات دیسپلاستیک سیروز استفاده کرد.[11]

گلیپیکان ۳ یک هدف درمانی امیدبخش برای درمان سرطان کبد و برخی سرطان‌های دیگر است.[9][12]

منابع

1. GRCh38: Ensembl release 89: ENSG00000147257 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055653 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pilia G, Hughes-Benzie RM, MacKenzie A, Baybayan P, Chen EY, Huber R, Neri G, Cao A, Forabosco A, Schlessinger D (March 1996). "Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome". Nature Genetics. 12 (3): 241–7. doi:10.1038/ng0396-241. PMID 8589713.
6. Veugelers M, Vermeesch J, Watanabe K, Yamaguchi Y, Marynen P, David G (October 1998). "GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome". Genomics. 53 (1): 1–11. doi:10.1006/geno.1998.5465. PMID 9787072.
7. "Entrez Gene: GPC3 glypican 3".
8. Jakubovic BD, Jothy S (April 2007). "Glypican-3: from the mutations of Simpson-Golabi-Behmel genetic syndrome to a tumor marker for hepatocellular carcinoma". Experimental and Molecular Pathology. 82 (2): 184–9. doi:10.1016/j.yexmp.2006.10.010. PMID 17258707.
9. Ho M, Kim H (February 2011). "Glypican-3: a new target for cancer immunotherapy". European Journal of Cancer. 47 (3): 333–8. doi:10.1016/j.ejca.2010.10.024. PMC 3031711. PMID 21112773.
10. Davoodi J, Kelly J, Gendron NH, MacKenzie AE (June 2007). "The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26". Proteomics. 7 (13): 2300–10. doi:10.1002/pmic.200600654. PMID 17549790.
11. Anatelli F, Chuang ST, Yang XJ, Wang HL (August 2008). "Value of glypican 3 immunostaining in the diagnosis of hepatocellular carcinoma on needle biopsy". American Journal of Clinical Pathology. 130 (2): 219–23. doi:10.1309/WMB5PX57Y4P8QCTY. PMID 18628090.
12. Li N, Gao W, Zhang YF, Ho M (November 2018). "Glypicans as Cancer Therapeutic Targets". Trends in Cancer. 4 (11): 741–754. doi:10.1016/j.trecan.2018.09.004. PMC 6209326. PMID 30352677.

• مشارکت‌کنندگان ویکی‌پدیا. «Glypican 3». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ سپتامبر ۲۰۱۹.

برای مطالعهٔ بیشتر

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• Filmus J (March 2001). "Glypicans in growth control and cancer". Glycobiology. 11 (3): 19R–23R. doi:10.1093/glycob/11.3.19R. PMID 11320054.
• Filmus J, Shi W, Wong ZM, Wong MJ (October 1995). "Identification of a new membrane-bound heparan sulphate proteoglycan". The Biochemical Journal. 311 ( Pt 2) (Pt 2): 561–5. doi:10.1042/bj3110561. PMC 1136036. PMID 7487896.
• Watanabe K, Yamada H, Yamaguchi Y (September 1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney". The Journal of Cell Biology. 130 (5): 1207–18. doi:10.1083/jcb.130.5.1207. PMC 2120559. PMID 7657705.
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• Shen T, Sonoda G, Hamid J, Li M, Filmus J, Buick RN, Testa JR (January 1997). "Mapping of the Simpson-Golabi-Behmel overgrowth syndrome gene (GPC3) to chromosome X in human and rat by fluorescence in situ hybridization". Mammalian Genome. 8 (1): 72. doi:10.1007/s003359900357. PMID 9021160.
• Lage H, Dietel M (April 1997). "Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5". Gene. 188 (2): 151–6. doi:10.1016/S0378-1119(96)00689-0. PMID 9133586.
• Huber R, Crisponi L, Mazzarella R, Chen CN, Su Y, Shizuya H, Chen EY, Cao A, Pilia G (October 1997). "Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene". Genomics. 45 (1): 48–58. doi:10.1006/geno.1997.4916. PMID 9339360.
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• Huber R, Mazzarella R, Chen CN, Chen E, Ireland M, Lindsay S, Pilia G, Crisponi L (December 1998). "Glypican 3 and glypican 4 are juxtaposed in Xq26.1". Gene. 225 (1–2): 9–16. doi:10.1016/S0378-1119(98)00549-6. PMID 9931407.
• Xuan JY, Hughes-Benzie RM, MacKenzie AE (January 1999). "A small interstitial deletion in the GPC3 gene causes Simpson-Golabi-Behmel syndrome in a Dutch-Canadian family". Journal of Medical Genetics. 36 (1): 57–8. doi:10.1136/jmg.36.1.57 (inactive 2019-08-18). PMC 1762951. PMID 9950367.
• Veugelers M, Cat BD, Muyldermans SY, Reekmans G, Delande N, Frints S, Legius E, Fryns JP, Schrander-Stumpel C, Weidle B, Magdalena N, David G (May 2000). "Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene". Human Molecular Genetics. 9 (9): 1321–8. doi:10.1093/hmg/9.9.1321. PMID 10814714.
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