DDR2

گیرندهٔ ۲ حاوی دومین دیسکوئیدین (انگلیسی: Discoidin domain-containing receptor 2‎) که با نام CD167b هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «DDR2» کُدگذاری می‌شود.[4]

DDR2
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 2WUH, 2Z4F
معین‌کننده‌ها
نام‌های دیگر	DDR2, MIG20a, NTRKR3, TKT, TYRO10, discoidin domain receptor tyrosine kinase 2, WRCN
شناسه‌های بیرونی	OMIM: 191311 MGI: 1345277 HomoloGene: 68505 GeneCards: DDR2
Gene location (Mouse) Chr. Chromosome 1 (mouse)[1] Band 1 H3|1 76.84 cM Start 169,972,307 bp[1] End 170,110,762 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • transferase activity • nucleotide binding • protein kinase activity • kinase activity • GO:0001948 پیوند پروتئینی • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase collagen receptor activity • protein tyrosine kinase activity • ATP binding • collagen binding ترکیبات سلولی • integral component of membrane • membrane • focal adhesion • integral component of plasma membrane • extracellular exosome • apical plasma membrane • پوسته یاخته • actin cytoskeleton • receptor complex فرایند زیستی • collagen-activated tyrosine kinase receptor signaling pathway • استخوان‌سازی • فسفرگیری • collagen fibril organization • transmembrane receptor protein tyrosine kinase signaling pathway • regulation of bone mineralization • positive regulation of fibroblast proliferation • biomineral tissue development • positive regulation of DNA-binding transcription factor activity • extracellular matrix organization • regulation of extracellular matrix disassembly • positive regulation of extracellular matrix disassembly • protein phosphorylation • cell adhesion • positive regulation of osteoblast differentiation • chondrocyte proliferation • positive regulation of cell population proliferation • peptidyl-tyrosine phosphorylation • endochondral bone growth • positive regulation of fibroblast migration • ورارسانی پیام • positive regulation of protein kinase activity • protein autophosphorylation • regulation of cell-matrix adhesion • cell-matrix adhesion • دگرگونی یاخته‌ • regulation of extracellular matrix organization Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	4921	18214
آنسامبل	ENSG00000162733	ENSMUSG00000026674
یونی‌پروت	Q16832	Q62371
RefSeq (mRNA)	NM_006182، XM_011509587، XM_011509588، NM_001354982، NM_001354983 NM_001014796، NM_006182، XM_011509587، XM_011509588، NM_001354982، NM_001354983	XM_006496696، XM_006496697، XM_006496698 NM_022563، XM_006496696، XM_006496697، XM_006496698
RefSeq (پروتئین)	NP_006173، XP_011507889، XP_011507890، NP_001341911، NP_001341912 NP_001014796، NP_006173، XP_011507889، XP_011507890، NP_001341911، NP_001341912	XP_006496759، XP_006496760، XP_006496761، XP_036018652 NP_072075، XP_006496759، XP_006496760، XP_006496761، XP_036018652
موقعیت (UCSC)	n/a	Chr : 169.97 – 170.11 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

این پروتئین نوعی تیروزین کیناز گیرنده‌ای است و نقش مهمی در ارتباطات سلول‌ها با محیط اطراف‌شان ایفا می‌کند.

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000026674 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: DDR2 discoidin domain receptor family, member 2".

• مشارکت‌کنندگان ویکی‌پدیا. «Discoidin domain-containing receptor 2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۵ سپتامبر ۲۰۱۹.

برای مطالعهٔ بیشتر

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