GCM1

فاکتور رونویسی GCMa اختصاصیِ کوریون (انگلیسی: Chorion-specific transcription factor GCMa‎) یک پروتئین است که در انسان توسط ژن «GCM1» کُدگذاری می‌شود[4][5] و نوعی پروتئین دی‌ان‌آ پیوست با یک موتیف ساختاری gcm است.

GCM1
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 1ODH
معین‌کننده‌ها
نام‌های دیگر	GCM1, GCMA, hGCMa, glial cells missing homolog 1, glial cells missing transcription factor 1
شناسه‌های بیرونی	OMIM: 603715 MGI: 108045 HomoloGene: 2702 GeneCards: GCM1
Gene location (Mouse) Chr. Chromosome 9 (mouse)[1] Band 9 E1|9 43.49 cM Start 78,051,924 bp[1] End 78,065,624 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • DNA binding • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity • zinc ion binding • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • histone deacetylase binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948 پیوند پروتئینی • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ترکیبات سلولی • transcription regulator complex • هسته یاخته فرایند زیستی • regulation of transcription, DNA-templated • anatomical structure morphogenesis • positive regulation of syncytium formation by plasma membrane fusion • transcription by RNA polymerase II • transcription, DNA-templated • multicellular organism development • branching involved in labyrinthine layer morphogenesis • astrocyte fate commitment • positive regulation of transcription by RNA polymerase II • gliogenesis • regulation of cell differentiation involved in embryonic placenta development • cell differentiation involved in embryonic placenta development Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	8521	14531
آنسامبل	ENSG00000137270	ENSMUSG00000023333
یونی‌پروت	Q9NP62	P70348
RefSeq (mRNA)	XM_017011390 NM_003643، XM_017011390	NM_008103
RefSeq (پروتئین)	XP_016866879 NP_003634، XP_016866879	NP_032129
موقعیت (UCSC)	n/a	Chr : 78.05 – 78.07 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

ریشهٔ آمینیِ دومِـین متصل‌شونده به دی‌ان‌ای در این پروتئین، حاوی یک جایگاه منحصربه‌فرد برای اتصال به مولکول دی‌ان‌ای است.[5]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000023333 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Akiyama Y, Hosoya T, Poole AM, Hotta Y (Jan 1997). "The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals". Proc Natl Acad Sci U S A. 93 (25): 14912–6. doi:10.1073/pnas.93.25.14912. PMC 26236. PMID 8962155.
5. "Entrez Gene: GCM1 glial cells missing homolog 1 (Drosophila)".

• مشارکت‌کنندگان ویکی‌پدیا. «GCM1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۵ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

• Yamada K, Ogawa H, Honda S, et al. (1999). "A GCM motif protein is involved in placenta-specific expression of human aromatase gene". J. Biol. Chem. 274 (45): 32279–86. doi:10.1074/jbc.274.45.32279. PMID 10542267.
• Nait-Oumesmar B, Copperman AB, Lazzarini RA (2000). "Placental expression and chromosomal localization of the human Gcm 1 gene". J. Histochem. Cytochem. 48 (7): 915–22. doi:10.1177/002215540004800704. PMID 10858268.
• Yamada K, Ogawa H, Tamiya G, et al. (2001). "Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene". Biochem. Biophys. Res. Commun. 278 (1): 134–9. doi:10.1006/bbrc.2000.3775. PMID 11071865.
• Yu C, Shen K, Lin M, et al. (2003). "GCMa regulates the syncytin-mediated trophoblastic fusion". J. Biol. Chem. 277 (51): 50062–8. doi:10.1074/jbc.M209316200. PMID 12397062.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Chen CP, Chen CY, Yang YC, et al. (2005). "Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia". Placenta. 25 (5): 413–21. doi:10.1016/j.placenta.2003.10.014. PMID 15081636.
• Baczyk D, Satkunaratnam A, Nait-Oumesmar B, et al. (2004). "Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta". Placenta. 25 (6): 553–9. doi:10.1016/j.placenta.2003.12.004. PMID 15135239.
• Schubert SW, Kardash E, Khan MA, et al. (2005). "Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2". J. Biol. Chem. 279 (48): 50358–65. doi:10.1074/jbc.M404587200. PMID 15385555.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yang CS, Yu C, Chuang HC, et al. (2005). "FBW2 targets GCMa to the ubiquitin-proteasome degradation system". J. Biol. Chem. 280 (11): 10083–90. doi:10.1074/jbc.M413986200. PMID 15640526.
• Knerr I, Schubert SW, Wich C, et al. (2005). "Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions". FEBS Lett. 579 (18): 3991–8. doi:10.1016/j.febslet.2005.06.029. PMID 16004993.
• Chang CW, Chuang HC, Yu C, et al. (2005). "Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa". Mol. Cell. Biol. 25 (19): 8401–14. doi:10.1128/MCB.25.19.8401-8414.2005. PMC 1265739. PMID 16166624.
• Chuang HC, Chang CW, Chang GD, et al. (2006). "Histone deacetylase 3 binds to and regulates the GCMa transcription factor". Nucleic Acids Res. 34 (5): 1459–69. doi:10.1093/nar/gkl048. PMC 1401512. PMID 16528103.
• Fujito N, Samura O, Miharu N, et al. (2007). "Increased plasma mRNAs of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia". Hiroshima J. Med. Sci. 55 (1): 9–15. PMID 16594548.
• Chou CC, Chang C, Liu JH, et al. (2007). "Small ubiquitin-like modifier modification regulates the DNA binding activity of glial cell missing Drosophila homolog a.". J. Biol. Chem. 282 (37): 27239–49. doi:10.1074/jbc.M700351200. PMID 17646165.