NLGN4X

NLGN4X
ساختارهای موجود
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2WQZ, 2XB6, 3BE8
معین‌کننده‌ها
نام‌های دیگر	NLGN4X, ASPGX2, AUTSX2, HLNX, HNL4X, NLGN4, neuroligin 4, X-linked, neuroligin 4 X-linked
شناسه‌های بیرونی	OMIM: 300427 HomoloGene: 136297 GeneCards: NLGN4X
Gene location (Human)
Chr.	X chromosome (human)[1]
End	6,228,867 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein homodimerization activity; • scaffold protein binding; • GO:0004091 carboxylic ester hydrolase activity; • neurexin family protein binding; • GO:0001948 پیوند پروتئینی; • chloride ion binding; • cell adhesion molecule binding; • signaling receptor activity;
ترکیبات سلولی	• integral component of membrane; • postsynaptic membrane; • membrane; • GO:0097483، GO:0097481 postsynaptic density; • سیناپس; • integral component of plasma membrane; • excitatory synapse; • cell surface; • پیوند میان‌یاخته‌ای; • دندریت; • پوسته یاخته; • intracellular anatomical structure; • spanning component of membrane; • presynapse; • symmetric, GABA-ergic, inhibitory synapse; • asymmetric, glutamatergic, excitatory synapse;
فرایند زیستی	• cell-cell junction organization; • organ growth; • neuron cell-cell adhesion; • brainstem development; • synapse organization; • یادگیری; • cerebellum development; • negative regulation of excitatory postsynaptic potential; • presynaptic membrane assembly; • vocalization behavior; • adult behavior; • cell adhesion; • neuron differentiation; • رفتار اجتماعی; • synaptic vesicle endocytosis; • postsynaptic membrane assembly; • modulation of chemical synaptic transmission; • presynapse assembly;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	57502
	n/a
	ENSG00000146938
	n/a
	Q8N0W4
	n/a
	NM_001282145، NM_001282146، NM_020742، NM_181332، XM_005274564، XM_005274565، XM_005274566، XM_006724504، XM_011545547، XM_017029691، XM_017029692، XM_017029693 XM_011545548، NM_001282145، NM_001282146، NM_020742، NM_181332، XM_005274564، XM_005274565، XM_005274566، XM_006724504، XM_011545547، XM_017029691، XM_017029692، XM_017029693
	n/a
	NP_001269075، NP_065793، NP_851849، XP_005274621، XP_005274622، XP_005274623، XP_006724567، XP_011543849، XP_011543850، XP_016885180، XP_016885181، XP_016885182 NP_001269074، NP_001269075، NP_065793، NP_851849، XP_005274621، XP_005274622، XP_005274623، XP_006724567، XP_011543849، XP_011543850، XP_016885180، XP_016885181، XP_016885182
	n/a
	ویکی‌داده
مشاهده/ویرایش Human

نورولایگین-۴، مرتبط با کروموزوم ایکس (انگلیسی: Neuroligin-4, X-linked‎) یک پروتئین است که در انسان توسط ژن «NLGN4X » کُدگذاری می‌شود.[3][4]

این پروتئین در شکل‌گیری و بازسازی سیناپس‌های دستگاه عصبی مرکزی نقش دارد و جهش در ژن آن، احتمالاً با بروز اوتیسم و سندرم آسپرگر در ارتباط است. دو گونه رونویسی متفاوت از این ژن وجود دارد که هر دو منجر به تولید یک پروتئین می‌گردد.[4]

منابع

GRCh38: Ensembl release 89: ENSG00000146938 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
"Entrez Gene: NLGN4X neuroligin 4, X-linked".

مشارکت‌کنندگان ویکی‌پدیا. «NLGN4X». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۰ مه ۲۰۱۸.

بیشتر بخوانید

Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ...". Curr. Biol. 10 (17): R620–3. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085.
Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515.
Bolliger MF, Frei K, Winterhalter KH, Gloor SM (2001). "Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression". Biochem. J. 356 (Pt 2): 581–8. doi:10.1042/0264-6021:3560581. PMC 1221872. PMID 11368788.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMC 1925054. PMID 12669065.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Laumonnier F, Bonnet-Brilhault F, Gomot M, et al. (2004). "X-Linked Mental Retardation and Autism Are Associated with a Mutation in the NLGN4 Gene, a Member of the Neuroligin Family". Am. J. Hum. Genet. 74 (3): 552–7. doi:10.1086/382137. PMC 1182268. PMID 14963808.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Yan J, Oliveira G, Coutinho A, et al. (2005). "Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients". Mol. Psychiatry. 10 (4): 329–32. doi:10.1038/sj.mp.4001629. PMID 15622415.
Blasi F, Bacchelli E, Pesaresi G, et al. (2006). "Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (3): 220–1. doi:10.1002/ajmg.b.30287. PMID 16508939.
Talebizadeh Z, Lam DY, Theodoro MF, et al. (2006). "Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism". J. Med. Genet. 43 (5): e21. doi:10.1136/jmg.2005.036897. PMC 2564526. PMID 16648374.
Yamakawa H, Oyama S, Mitsuhashi H, et al. (2007). "Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations". Biochem. Biophys. Res. Commun. 355 (1): 41–6. doi:10.1016/j.bbrc.2007.01.127. PMID 17292328.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146938 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10574462-3] Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (Jan 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.

[entrez-4] "Entrez Gene: NLGN4X neuroligin 4, X-linked".