PRDX4

PRDX4
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PN8, 3TJB, 3TJF, 3TJG, 3TJJ, 3TJK, 3TKP, 3TKQ, 3TKR, 3TKS, 4RQX
معین‌کننده‌ها
نام‌های دیگر	PRDX4, AOE37-2, AOE372, HEL-S-97n, PRX-4, peroxiredoxin 4
شناسه‌های بیرونی	OMIM: 300927 MGI: 1859815 HomoloGene: 4672 GeneCards: PRDX4
Gene location (Human)
Chr.	X chromosome (human)[1]
End	23,686,397 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	155,340,754 bp[2]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein homodimerization activity; • peroxidase activity; • thioredoxin peroxidase activity; • antioxidant activity; • GO:0001948 پیوند پروتئینی; • peroxiredoxin activity; • oxidoreductase activity;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • smooth endoplasmic reticulum; • شبکه آندوپلاسمی; • میتوکندری; • extracellular exosome; • هسته یاخته; • extracellular space; • secretory granule lumen; • ficolin-1-rich granule lumen; • extracellular region;
فرایند زیستی	• male gonad development; • 4-hydroxyproline metabolic process; • extracellular matrix organization; • I-kappaB phosphorylation; • protein maturation by protein folding; • cell redox homeostasis; • reactive oxygen species metabolic process; • اسپرماتوژنز; • negative regulation of male germ cell proliferation; • cellular oxidant detoxification; • neutrophil degranulation; • response to oxidative stress; • hydrogen peroxide catabolic process;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	10549
	53381
	ENSG00000123131
	ENSMUSG00000025289
	Q13162
	O08807
	NM_006406
	NM_001313711، XM_011247844 NM_016764، NM_001313711، XM_011247844
	NP_006397
	NP_058044، XP_011246146 NP_001300640، NP_058044، XP_011246146
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروکسی‌ردوکسین ۴ (انگلیسی: Peroxiredoxin-4‎) یک پروتئین است که در انسان توسط ژن «PRDX4» کُدگذاری می‌شود.[5][6] این آنزیم یکی از اعضای خانوادهٔ آنزیم‌های آنتی‌اکسیدانی پروکسی‌ردوکسین است.

جایگاه این پروتئین در سیتوپلاسم سلول است و نقش تنظیمی مهمی در فعال‌شدن فاکتور رونویسی NF-κB ایفا می‌کند.[6]

منابع

GRCh38: Ensembl release 89: ENSG00000123131 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025289 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jin DY, Chae HZ, Rhee SG, Jeang KT (Jan 1998). "Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation". J. Biol. Chem. 272 (49): 30952–61. doi:10.1074/jbc.272.49.30952. PMID 9388242.
"Entrez Gene: PRDX4 peroxiredoxin 4".

مشارکت‌کنندگان ویکی‌پدیا. «PRDX4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۶ آوریل ۲۰۱۸.

بیشتر بخوانید

Sasagawa I, Matsuki S, Suzuki Y, Iuchi Y, Tohya K, Kimura M, Nakada T, Fujii J (2001). "Possible involvement of the membrane-bound form of peroxiredoxin 4 in acrosome formation during spermiogenesis of rats". Eur. J. Biochem. 268 (10): 3053–61. doi:10.1046/j.1432-1327.2001.02200.x. PMID 11358524.
Wagner E, Luche S, Penna L, Chevallet M, Van Dorsselaer A, Leize-Wagner E, Rabilloud T (2002). "A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress". Biochem. J. 366 (Pt 3): 777–85. doi:10.1042/BJ20020525. PMC 1222825. PMID 12059788.
Shen C, Nathan C (2002). "Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells". Mol. Med. 8 (2): 95–102. PMC 2039972. PMID 12080185.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
Giguère P, Turcotte ME, Hamelin E, Parent A, Brisson J, Laroche G, Labrecque P, Dupuis G, Parent JL (2007). "Peroxiredoxin-4 interacts with and regulates the thromboxane A(2) receptor". FEBS Lett. 581 (20): 3863–8. doi:10.1016/j.febslet.2007.07.011. PMID 17644091.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123131 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025289 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9388242-5] Jin DY, Chae HZ, Rhee SG, Jeang KT (Jan 1998). "Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation". J. Biol. Chem. 272 (49): 30952–61. doi:10.1074/jbc.272.49.30952. PMID 9388242.

[entrez-6] "Entrez Gene: PRDX4 peroxiredoxin 4".