اکتینین آلفا ۴

اکتینین آلفا ۴ (انگلیسی: Actinin alpha 4‎) یک پروتئین است که در انسان توسط ژن «ACTN4» کُدگذاری می‌شود.[4]

ACTN4
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 1WLX, 1YDI, 2R0O
معین‌کننده‌ها
نام‌های دیگر	ACTN4, ACTININ-4, FSGS, FSGS1, Actinin alpha 4
شناسه‌های بیرونی	OMIM: 604638 MGI: 1890773 HomoloGene: 55857 GeneCards: ACTN4
Gene location (Mouse) Chr. Chromosome 7 (mouse)[1] Band 7|7 B1 Start 28,893,248 bp[1] End 28,962,340 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • metal ion binding • calcium ion binding • actin binding • GO:0032403 protein-containing complex binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • protein homodimerization activity • protein N-terminus binding • nucleoside binding • ion channel binding • nuclear receptor coactivator activity • integrin binding • retinoic acid receptor binding • chromatin DNA binding • GO:0001948 پیوند پروتئینی • actin filament binding • RNA binding • GO:0001105 transcription coactivator activity ترکیبات سلولی • extracellular exosome • extracellular region • brush border • پای کاذب • سیتوپلاسم • actin cytoskeleton • پیوند میان‌یاخته‌ای • هسته یاخته • stress fiber • cell-cell junction • neuron projection • focal adhesion • platelet alpha granule lumen • intracellular anatomical structure • Z disc • perinuclear region of cytoplasm • cortical cytoskeleton • extracellular space • سیتوزول • nuclear body • اسکلت سلولی • protein-containing complex • ribonucleoprotein complex فرایند زیستی • response to hypoxia • vesicle transport along actin filament • actin filament bundle assembly • positive regulation of NIK/NF-kappaB signaling • regulation of apoptotic process • positive regulation of cell migration • negative regulation of cellular component movement • bicellular tight junction assembly • positive regulation of sodium:proton antiporter activity • protein localization to bicellular tight junction • platelet degranulation • positive regulation of pinocytosis • retinoic acid receptor signaling pathway • regulation of nucleic acid-templated transcription • protein transport • peroxisome proliferator activated receptor signaling pathway • negative regulation of substrate adhesion-dependent cell spreading • positive regulation of cellular component movement • transport • tumor necrosis factor-mediated signaling pathway • positive regulation of nucleic acid-templated transcription Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	81	60595
آنسامبل	ENSG00000130402 ENSG00000282844	ENSMUSG00000054808
یونی‌پروت	O43707	P57780
RefSeq (mRNA)	NM_004924، XM_005259281، NM_001322033، XM_017027331 XM_006723406، NM_004924، XM_005259281، NM_001322033، XM_017027331	XM_006540255، XM_006540257، NM_001360548، NM_001360549، NM_001360550 NM_021895، XM_006540255، XM_006540257، NM_001360548، NM_001360549، NM_001360550
RefSeq (پروتئین)	NP_004915، XP_005259338، XP_006723469، XP_016882820 NP_001308962، NP_004915، XP_005259338، XP_006723469، XP_016882820	XP_006540318، XP_006540320، NP_001347477، NP_001347478، NP_001347479، XP_036009204، XP_036009205 NP_068695، XP_006540318، XP_006540320، NP_001347477، NP_001347478، NP_001347479، XP_036009204، XP_036009205
موقعیت (UCSC)	n/a	Chr : 28.89 – 28.96 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

آلفا اکتینین‌ها متعلق به ابرخانوادهٔ اسپکترین هستند که از پروتئین‌های ساختار اسکلتی سلول محسوب می‌شوند.

جهش در این ژن با بروز نوعی خاص از بیماری کلیوی به نام «گلومرولونفروز موضعی ناحیه‌ای» در ارتباط است.[4]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000054808 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: ACTN4 actinin, alpha 4".

• مشارکت‌کنندگان ویکی‌پدیا. «Actinin alpha 4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۵ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Yürüker B, Niggli V (1992). "Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network". J. Cell Sci. 101. ( Pt 2): 403–14. PMID 1629252.
• Otey CA, Pavalko FM, Burridge K (1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro". J. Cell Biol. 111 (2): 721–9. doi:10.1083/jcb.111.2.721. PMC 2116186. PMID 2116421.
• Pavalko FM, LaRoche SM (1993). "Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". J. Immunol. 151 (7): 3795–807. PMID 8104223.
• Mathis BJ, Kim SH, Calabrese K, et al. (1998). "A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13". Kidney Int. 53 (2): 282–6. doi:10.1046/j.1523-1755.1998.00828.x. PMID 9461087.
• Honda K, Yamada T, Endo R, et al. (1998). "Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion". J. Cell Biol. 140 (6): 1383–93. doi:10.1083/jcb.140.6.1383. PMC 2132673. PMID 9508771.
• Zhang H, Wang L, Kao S, et al. (1999). "Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF". Curr. Biol. 9 (21): 1271–4. doi:10.1016/S0960-9822(99)80511-9. PMC 4513661. PMID 10556093.
• Nikolopoulos SN, Spengler BA, Kisselbach K, et al. (2000). "The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells". Oncogene. 19 (3): 380–6. doi:10.1038/sj.onc.1203310. PMID 10656685.
• El-Husseini AE, Kwasnicka D, Yamada T, et al. (2000). "BERP, a novel ring finger protein, binds to alpha-actinin-4". Biochem. Biophys. Res. Commun. 267 (3): 906–11. doi:10.1006/bbrc.1999.2045. PMID 10673389.
• Kaplan JM, Kim SH, North KN, et al. (2000). "Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis". Nat. Genet. 24 (3): 251–6. doi:10.1038/73456. PMID 10700177.
• Vallenius T, Luukko K, Mäkelä TP (2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4". J. Biol. Chem. 275 (15): 11100–5. doi:10.1074/jbc.275.15.11100. PMID 10753915.
• Holliday LS, Lu M, Lee BS, et al. (2000). "The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site". J. Biol. Chem. 275 (41): 32331–7. doi:10.1074/jbc.M004795200. PMID 10915794.
• Walikonis RS, Oguni A, Khorosheva EM, et al. (2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. 21 (2): 423–33. PMID 11160423.
• Echchakir H, Mami-Chouaib F, Vergnon I, et al. (2001). "A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma". Cancer Res. 61 (10): 4078–83. PMID 11358829.
• Xu F, Zhao R, Peng Y, et al. (2001). "Association of tyrosine phosphatase SHP-2 with F-actin at low cell densities". J. Biol. Chem. 276 (31): 29479–84. doi:10.1074/jbc.M104428200. PMID 11382784.
• Hüttelmaier S, Illenberger S, Grosheva I, et al. (2002). "Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins". J. Cell Biol. 155 (5): 775–86. doi:10.1083/jcb.200105044. PMC 2150882. PMID 11724819.
• Renoult C, Blondin L, Fattoum A, et al. (2002). "Binding of gelsolin domain 2 to actin. An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin". Eur. J. Biochem. 268 (23): 6165–75. doi:10.1046/j.0014-2956.2001.02574.x. PMID 11733011.
• Gonzalez AM, Otey C, Edlund M, Jones JC (2002). "Interactions of a hemidesmosome component and actinin family members". J. Cell Sci. 114 (Pt 23): 4197–206. PMID 11739652.
• Lukoyanova N, VanLoock MS, Orlova A, et al. (2002). "Each actin subunit has three nebulin binding sites: implications for steric blocking". Curr. Biol. 12 (5): 383–8. doi:10.1016/S0960-9822(02)00678-4. PMID 11882289.
• Kim JH, Lee-Kwon W, Park JB, et al. (2002). "Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis". J. Biol. Chem. 277 (26): 23714–24. doi:10.1074/jbc.M200835200. PMID 11948184.

پیوند به بیرون

• مکان ژنوم ACTN4 انسانی و صفحهٔ جزئیات ژنی ACTN4 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.