AMFR

AMFR
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EJS, 2LVN, 2LVO, 2LVP, 2LVQ, 2LXH, 2LXP, 3FSH, 3H8K, 3TIW, 4G3O, 4LAD
معین‌کننده‌ها
نام‌های دیگر	AMFR, GP78, RNF45, autocrine motility factor receptor
شناسه‌های بیرونی	OMIM: 603243 MGI: 1345634 HomoloGene: 888 GeneCards: AMFR
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[1]
End	94,012,842 bp[1]
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein-macromolecule adaptor activity; • chaperone binding; • GO:1904264، GO:1904822، GO:0090622، GO:0090302 ubiquitin protein ligase activity; • metal ion binding; • ubiquitin-protein transferase activity; • ubiquitin-ubiquitin ligase activity; • GO:0001948 پیوند پروتئینی; • ubiquitin-specific protease binding; • transferase activity; • identical protein binding; • BAT3 complex binding; • signaling receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • membrane; • growth cone; • integral component of endoplasmic reticulum membrane; • neuronal cell body; • دندریت; • Derlin-1 retrotranslocation complex; • perinuclear region of cytoplasm; • هسته یاخته; • شبکه آندوپلاسمی; • endoplasmic reticulum membrane; • دستگاه گلژی; • endoplasmic reticulum quality control compartment; • protein-containing complex; • ubiquitin ligase complex; • سیتوزول;
فرایند زیستی	• movement of cell or subcellular component; • ERAD pathway; • ubiquitin-dependent protein catabolic process; • پیرش; • protein polyubiquitination; • endoplasmic reticulum unfolded protein response; • protein K48-linked ubiquitination; • protein complex oligomerization; • protein ubiquitination; • ubiquitin-dependent ERAD pathway; • learning or memory; • positive regulation of protein binding; • ورارسانی پیام; • protein autoubiquitination; • تاشدگی پروتئین; • endoplasmic reticulum mannose trimming;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	267
	23802
	ENSG00000159461
	ENSMUSG00000031751
	Q9UKV5
	Q9R049
	NM_001144، NM_138958، NM_001323511، NM_001323512 XM_005255890، NM_001144، NM_138958، NM_001323511، NM_001323512
	XM_017312768 NM_011787، XM_017312768
	NP_001310440، NP_001310441، XP_005255947 NP_001135، NP_001310440، NP_001310441، XP_005255947
	XP_017168257 NP_035917، XP_017168257
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

گیرندهٔ عامل تحرک اتوکرین، ایزوفرم ۲ (انگلیسی: Autocrine motility factor receptor, isoform 2‎) یک پروتئین است که در انسان توسط ژن «AMFR» کدگذاری می‌شود.[4][5]

عامل تحرک اتوکرین یک پروتئین تحریک‌کنندهٔ جابجایی تومور است که توسط سلول‌های تومور ترشح می‌شود و در بروز متاستازهای سرطانی نقش دارد.[6] گیرندهٔ این پروتئین شباهت‌هایی از لحاظ توالی ژنی به پروتئین p53 دارد و در پخش شدن تومور مؤثر است.[5]

جستارهای وابسته

منابع

GRCm38: Ensembl release 89: ENSMUSG00000031751 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A (Aug 1991). "Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor". J Biol Chem. 266 (20): 13442–8. PMID 1649192.
"Entrez Gene: AMFR autocrine motility factor receptor".
Watanabe H, Takehana K, Date M, Shinozaki T, Raz A (1 July 1996). "Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide". Cancer Res. 56 (13): 2960–3. PMID 8674049.

مشارکت‌کنندگان ویکی‌پدیا. «AMFR». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۰ اکتبر ۲۰۱۸.

بیشتر بخوانید

Huang B, Xie Y, Raz A (1995). "Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor". Biochem. Biophys. Res. Commun. 212 (3): 727–42. doi:10.1006/bbrc.1995.2031. PMID 7626106.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Shimizu K, Tani M, Watanabe H, et al. (1999). "The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein". FEBS Lett. 456 (2): 295–300. doi:10.1016/S0014-5793(99)00966-7. PMID 10456327.
Fang S, Ferrone M, Yang C, et al. (2002). "The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14422–7. Bibcode:2001PNAS...9814422F. doi:10.1073/pnas.251401598. PMC 64697. PMID 11724934.
Luo Y, Long JM, Lu C, et al. (2002). "A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78". J. Neurochem. 80 (2): 354–61. doi:10.1046/j.0022-3042.2001.00707.x. PMID 11902125.
Tímár J, Rásó E, Döme B, et al. (2002). "Expression and function of the AMF receptor by human melanoma in experimental and clinical systems". Clin. Exp. Metastasis. 19 (3): 225–32. doi:10.1023/A:1015595708241. PMID 12067203.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liang JS, Kim T, Fang S, et al. (2003). "Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells". J. Biol. Chem. 278 (26): 23984–8. doi:10.1074/jbc.M302683200. PMID 12670940.
Takanami I, Takeuchi K (2003). "Autocrine motility factor-receptor gene expression in lung cancer". Jpn. J. Thorac. Cardiovasc. Surg. 51 (8): 368–73. doi:10.1007/BF02719469. PMID 12962414.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Registre M, Goetz JG, St Pierre P, et al. (2004). "The gene product of the gp78/AMFR ubiquitin E3 ligase cDNA is selectively recognized by the 3F3A antibody within a subdomain of the endoplasmic reticulum". Biochem. Biophys. Res. Commun. 320 (4): 1316–22. doi:10.1016/j.bbrc.2004.06.089. PMID 15303277.
Zhong X, Shen Y, Ballar P, et al. (2004). "AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation". J. Biol. Chem. 279 (44): 45676–84. doi:10.1074/jbc.M409034200. PMID 15331598.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Song BL, Sever N, DeBose-Boyd RA (2005). "Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase". Mol. Cell. 19 (6): 829–40. doi:10.1016/j.molcel.2005.08.009. PMID 16168377.
Kaynak K, Kara M, Oz B, et al. (2006). "Autocrine motility factor receptor expression implies an unfavourable prognosis in resected stage I pulmonary adenocarcinomas". Acta Chir. Belg. 105 (4): 378–82. PMID 16184720.
Ye Y, Shibata Y, Kikkert M, et al. (2006). "Inaugural Article: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14132–8. Bibcode:2005PNAS..10214132Y. doi:10.1073/pnas.0505006102. PMC 1242302. PMID 16186510.
Chen B, Mariano J, Tsai YC, et al. (2006). "The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site". Proc. Natl. Acad. Sci. U.S.A. 103 (2): 341–6. Bibcode:2006PNAS..103..341C. doi:10.1073/pnas.0506618103. PMC 1326157. PMID 16407162.
Haga A, Tanaka N, Funasaka T, et al. (2006). "The autocrine motility factor (AMF) and AMF-receptor combination needs sugar chain recognition ability and interaction using the C-terminal region of AMF". J. Mol. Biol. 358 (3): 741–53. doi:10.1016/j.jmb.2006.02.046. PMID 16563432.
Shen Y, Ballar P, Fang S (2006). "Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin". Biochem. Biophys. Res. Commun. 349 (4): 1285–93. doi:10.1016/j.bbrc.2006.08.173. PMID 16979136.

پیوند به بیرون

مکان ژنوم AMFR انسانی و صفحهٔ جزئیات ژنی AMFR در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000031751 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1649192-4] Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A (Aug 1991). "Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor". J Biol Chem. 266 (20): 13442–8. PMID 1649192.

[entrez-5] "Entrez Gene: AMFR autocrine motility factor receptor".

[6] Watanabe H, Takehana K, Date M, Shinozaki T, Raz A (1 July 1996). "Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide". Cancer Res. 56 (13): 2960–3. PMID 8674049.