BNIP3

BNIP3
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2J5D, 2KA1, 2KA2
معین‌کننده‌ها
نام‌های دیگر	BNIP3, NIP3, BCL2/adenovirus E1B 19kDa interacting protein 3, BCL2 interacting protein 3
شناسه‌های بیرونی	OMIM: 603293 MGI: 109326 HomoloGene: 2990 GeneCards: BNIP3
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[1]
End	138,909,519 bp[1]
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein homodimerization activity; • GO:0001948 پیوند پروتئینی; • identical protein binding; • protein heterodimerization activity; • GTPase binding;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • nuclear envelope; • mitochondrial membrane; • membrane; • integral component of mitochondrial outer membrane; • نوکلئوپلاسم; • mitochondrial outer membrane; • دندریت; • شبکه آندوپلاسمی; • میتوکندری; • mitochondrial envelope; • هسته یاخته; • GO:0097483، GO:0097481 postsynaptic density;
فرایند زیستی	• neuron apoptotic process; • regulation of aerobic respiration; • mitochondrial fragmentation involved in apoptotic process; • positive regulation of mitochondrial fission; • response to hypoxia; • positive regulation of autophagy; • regulation of mitochondrion organization; • response to hyperoxia; • positive regulation of cardiac muscle cell apoptotic process; • مرگ یاخته; • negative regulation of apoptotic process; • positive regulation of programmed cell death; • negative regulation of cell death; • toxin transport; • negative regulation of membrane potential; • reactive oxygen species metabolic process; • intrinsic apoptotic signaling pathway; • positive regulation of macroautophagy; • positive regulation of protein-containing complex disassembly; • cellular response to mechanical stimulus; • cellular response to cobalt ion; • regulation of mitochondrial membrane permeability; • میتوفاژی; • defense response to virus; • intrinsic apoptotic signaling pathway in response to hypoxia; • brown fat cell differentiation; • positive regulation of apoptotic process; • positive regulation of release of cytochrome c from mitochondria; • negative regulation of reactive oxygen species metabolic process; • GO:0022415 viral process; • negative regulation of mitochondrial fusion; • granzyme-mediated apoptotic signaling pathway; • mitochondrial outer membrane permeabilization; • mitochondrial protein catabolic process; • autophagic cell death; • cellular response to hydrogen peroxide; • مرگ برنامه‌ریزی‌شده یاخته; • cardiac muscle cell apoptotic process; • negative regulation of mitochondrial membrane potential; • positive regulation of necrotic cell death; • cerebral cortex development; • oligodendrocyte differentiation; • positive regulation of mitochondrial calcium ion concentration; • cellular response to hypoxia; • negative regulation of mitochondrial membrane permeability involved in apoptotic process; • positive regulation of autophagy of mitochondrion; • response to bacterium;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	664
	12176
	ENSG00000176171
	ENSMUSG00000078566
	Q12983
	O55003
	NM_004052
	NM_009760
	NP_004043
	NP_033890
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین ۳ واکنش‌دهنده با پروتئین ۱۹ کیلو دالتونی E1B 19 آدنوویروس/E1B 19 (انگلیسی: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3‎) یک پروتئین است که در انسان توسط ژن «BNIP3» کُدگذاری می‌شود.[4]

این پروتئین عضوی از خانوادهٔ Bcl-2 است و در آپوپتوز نقش مهمی دارد و نفوذپذیری غشاء خارجی میتوکندری را با تشکیل هومو- و هترواولیگومرهایی در درون غشاء کنترل می‌کند.[5] افزایش این پروتئین سبب کاهش پتانسیل الکتریکی میتوکندری، افزایش رادیکال‌های آزاد اکسیژن، تورم و شکافتگی در میتوکندری و مرگ آنها از طریق خودخواری می‌گردد.[6]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000078566 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, et al. (October 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341–51. doi:10.1016/0092-8674(94)90202-X. PMID 7954800. S2CID 38609845.
Sassone J, Colciago C, Marchi P, Ascardi C, Alberti L, Di Pardo A, et al. (January 2010). "Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)". Cell Death & Disease. 1 (1): e7. doi:10.1038/cddis.2009.6. PMC 3032515. PMID 21364626.
Liu KE, Frazier WA (2015-06-23). "Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy". PLOS ONE. 10 (6): e0129667. Bibcode:2015PLoSO..1029667L. doi:10.1371/journal.pone.0129667. PMC 4477977. PMID 26102349.

مشارکت‌کنندگان ویکی‌پدیا. «BNIP3». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۸ اکتبر ۲۰۲۰.

برای مطالعهٔ بیشتر

Kataoka N, Ohno M, Moda I, Shimura Y (September 1995). "Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein". Nucleic Acids Research. 23 (18): 3638–41. doi:10.1093/nar/23.18.3638. PMC 307259. PMID 7478990.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Chen G, Ray R, Dubik D, Shi L, Cizeau J, Bleackley RC, et al. (December 1997). "The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis". The Journal of Experimental Medicine. 186 (12): 1975–83. doi:10.1084/jem.186.12.1975. PMC 2199165. PMID 9396766.
Yasuda M, Theodorakis P, Subramanian T, Chinnadurai G (May 1998). "Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence". The Journal of Biological Chemistry. 273 (20): 12415–21. doi:10.1074/jbc.273.20.12415. PMID 9575197.
Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, et al. (January 1999). "Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins". The Journal of Biological Chemistry. 274 (1): 7–10. doi:10.1074/jbc.274.1.7. PMID 9867803.
Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G (February 1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3". Cancer Research. 59 (3): 533–7. PMID 9973195.
Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, et al. (April 1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region". Cell Death and Differentiation. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623.
Ray R, Chen G, Vande Velde C, Cizeau J, Park JH, Reed JC, et al. (January 2000). "BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites". The Journal of Biological Chemistry. 275 (2): 1439–48. doi:10.1074/jbc.275.2.1439. PMID 10625696.
Vande Velde C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, et al. (August 2000). "BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore". Molecular and Cellular Biology. 20 (15): 5454–68. doi:10.1128/MCB.20.15.5454-5468.2000. PMC 85997. PMID 10891486.
Lee SM, Li ML, Tse YC, Leung SC, Lee MM, Tsui SK, et al. (September 2002). "Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway". Life Sciences. 71 (19): 2267–77. doi:10.1016/S0024-3205(02)01962-8. PMID 12215374.
Lamy L, Ticchioni M, Rouquette-Jazdanian AK, Samson M, Deckert M, Greenberg AH, Bernard A (June 2003). "CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis". The Journal of Biological Chemistry. 278 (26): 23915–21. doi:10.1074/jbc.M301869200. PMID 12690108.
Kothari S, Cizeau J, McMillan-Ward E, Israels SJ, Bailes M, Ens K, et al. (July 2003). "BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF". Oncogene. 22 (30): 4734–44. doi:10.1038/sj.onc.1206666. PMID 12879018.
Okami J, Simeone DM, Logsdon CD (August 2004). "Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer". Cancer Research. 64 (15): 5338–46. CiteSeerX 10.1.1.326.628. doi:10.1158/0008-5472.CAN-04-0089. PMID 15289340. S2CID 16163067.
Giatromanolaki A, Koukourakis MI, Sowter HM, Sivridis E, Gibson S, Gatter KC, Harris AL (August 2004). "BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer". Clinical Cancer Research. 10 (16): 5566–71. doi:10.1158/1078-0432.CCR-04-0076. PMID 15328198.
Shen XY, Zacal N, Singh G, Rainbow AJ (2005). "Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells". Photochemistry and Photobiology. 81 (2): 306–13. doi:10.1562/2004-07-22-RA-242. PMID 15560738.

پیوند به بیرون

مکان ژنوم BNIP3 انسانی و صفحهٔ جزئیات ژنی BNIP3 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000078566 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7954800-4] Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, et al. (October 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341–51. doi:10.1016/0092-8674(94)90202-X. PMID 7954800. S2CID 38609845.

[5] Sassone J, Colciago C, Marchi P, Ascardi C, Alberti L, Di Pardo A, et al. (January 2010). "Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)". Cell Death & Disease. 1 (1): e7. doi:10.1038/cddis.2009.6. PMC 3032515. PMID 21364626.

[:1-6] Liu KE, Frazier WA (2015-06-23). "Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy". PLOS ONE. 10 (6): e0129667. Bibcode:2015PLoSO..1029667L. doi:10.1371/journal.pone.0129667. PMC 4477977. PMID 26102349.