HCK

تیروزین-پروتئین کیناز HCK (انگلیسی: Tyrosine-protein kinase HCK‎) یک آنزیم است که در انسان توسط ژن «HCK» کُدگذاری می‌شود.[4]

HCK
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 1AD5, 1BU1, 1QCF, 2C0I, 2C0O, 2C0T, 2HCK, 2HK5, 2OI3, 2OJ2, 3HCK, 3NHN, 3RBB, 3REA, 3REB, 3VRY, 3VRZ, 3VS0, 3VS1, 3VS2, 3VS3, 3VS4, 3VS5, 3VS6, 3VS7, 4HCK, 4LUD, 4LUE, 4ORZ, 4U5W, 5HCK
معین‌کننده‌ها
نام‌های دیگر	HCK, JTK9, p59Hck, p61Hck, HCK proto-oncogene, Src family tyrosine kinase
شناسه‌های بیرونی	OMIM: 142370 MGI: 96052 HomoloGene: 20489 GeneCards: HCK
Gene location (Mouse) Chr. Chromosome 2 (mouse)[1] Band 2 H1|2 75.41 cM Start 153,108,468 bp[1] End 153,151,441 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • kinase activity • GO:0001948 پیوند پروتئینی • signaling receptor binding • ATP binding • protein tyrosine kinase activity • phosphotyrosine residue binding ترکیبات سلولی • سیتوپلاسم • سیتوزول • دستگاه گلژی • cell projection • membrane • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • transport vesicle • پیوند میان‌یاخته‌ای • ریزرشته • حفره غشایی • کافنده‌تن • اسکلت سلولی • GO:0016023 cytoplasmic vesicle • هسته یاخته • نوکلئوپلاسم • پوسته یاخته فرایند زیستی • دگرگونی یاخته‌ • leukocyte migration involved in immune response • positive regulation of actin filament polymerization • Fc-gamma receptor signaling pathway involved in phagocytosis • فسفرگیری • transmembrane receptor protein tyrosine kinase signaling pathway • cytokine-mediated signaling pathway • interferon-gamma-mediated signaling pathway • immune system process • leukocyte degranulation • negative regulation of apoptotic process • regulation of defense response to virus by virus • protein phosphorylation • cell adhesion • respiratory burst after phagocytosis • regulation of DNA-binding transcription factor activity • positive regulation of cell population proliferation • regulation of inflammatory response • regulation of cell shape • regulation of podosome assembly • peptidyl-tyrosine autophosphorylation • بیگانه‌خواری • integrin-mediated signaling pathway • protein autophosphorylation • peptidyl-tyrosine phosphorylation • regulation of phagocytosis • mesoderm development • inflammatory response • innate immune response-activating signal transduction • positive regulation of actin cytoskeleton reorganization • lipopolysaccharide-mediated signaling pathway • اگزوسیتوز • GO:0022415 viral process • دستگاه ایمنی ذاتی Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	3055	15162
آنسامبل	ENSG00000101336	ENSMUSG00000003283
یونی‌پروت	P08631	P08103
RefSeq (mRNA)	NM_001172129، NM_001172130، NM_001172131، NM_001172132، NM_001172133 NM_002110، NM_001172129، NM_001172130، NM_001172131، NM_001172132، NM_001172133	NM_010407 NM_001172117، NM_010407
RefSeq (پروتئین)	NP_001165601، NP_001165602، NP_001165603، NP_001165604، NP_002101 NP_001165600، NP_001165601، NP_001165602، NP_001165603، NP_001165604، NP_002101	NP_034537 NP_001165588، NP_034537
موقعیت (UCSC)	n/a	Chr : 153.11 – 153.15 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

این پروتئین با گیرنده فاکتور محرک کلونی گرانولوسیت[5] و RASA1[6] تعامل پروتئین-پروتئین دارد.

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000003283 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD (August 1987). "Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells". Mol Cell Biol. 7 (6): 2267–75. PMC 365351. PMID 3496523.
5. Ward AC, Monkhouse JL, Csar XF, Touw IP, Bello PA (Oct 1998). "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor". Biochemical and Biophysical Research Communications. 251 (1): 117–23. doi:10.1006/bbrc.1998.9441. PMID 9790917.
6. Briggs SD, Bryant SS, Jove R, Sanderson SD, Smithgall TE (Jun 1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". The Journal of Biological Chemistry. 270 (24): 14718–24. doi:10.1074/jbc.270.24.14718. PMID 7782336.

• مشارکت‌کنندگان ویکی‌پدیا. «HCK». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

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• Liao F, Shin HS, Rhee SG (1993). "In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases". Biochem. Biophys. Res. Commun. (Submitted manuscript). 191 (3): 1028–33. doi:10.1006/bbrc.1993.1320. PMID 7682059.
• Briggs SD, Bryant SS, Jove R, Sanderson SD, Smithgall TE (1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". J. Biol. Chem. 270 (24): 14718–24. doi:10.1074/jbc.270.24.14718. PMID 7782336.
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