نوروکن

NCAN
معین‌کننده‌ها
نام‌های دیگر	NCAN, CSPG3, neurocan
شناسه‌های بیرونی	OMIM: 600826 MGI: 104694 HomoloGene: 3229 GeneCards: NCAN
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[1]
End	70,120,873 bp[1]
هستی‌شناسی ژن
عملکرد ملکولی	• calcium ion binding; • hyaluronic acid binding; • carbohydrate binding; • extracellular matrix structural constituent;
ترکیبات سلولی	• Golgi lumen; • extracellular region; • lysosomal lumen; • GO:0005578 بافت‌مانه برون‌یاخته‌ای;
فرایند زیستی	• chondroitin sulfate catabolic process; • skeletal system development; • central nervous system development; • chondroitin sulfate biosynthetic process; • extracellular matrix organization; • dermatan sulfate biosynthetic process; • cell adhesion;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	1463
	13004
	ENSG00000130287
	ENSMUSG00000002341
	O14594
	P55066
	NM_004386
	XM_006509543 NM_007789، XM_006509543
	NP_004377
	NP_031815
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

پروتئین اصلی نوروکَن (انگلیسی: Neurocan core protein‎) که به‌اختصار «نوروکَن» گفته می‌شود، پروتئینی است که در انسان توسط ژن «NCAN» کُد می‌شود.[4][5]

این مولکول یکی از اعضای خانوادهٔ لکتیکن/پروتئیوگلیکان‌های کوندروتین سولفات است و نقش احتمالی آن در یاخته‌ها، چسبندگی سلولی و جابجایی آنهاست.[5]

در یک بررسی ژنتیکی در سال ۲۰۱۱ میلادی، ارتباط بین این پروتئین و اختلال دوقطبی مطرح شد.[6] سپس در سال ۲۰۱۲ یک پژوهش گسترده نشان داد که واقعاً چنین ارتباطی وجود دارد.[7]

منابع

GRCm38: Ensembl release 89: ENSMUSG00000002341 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Rauch U, Karthikeyan L, Maurel P, Margolis RU, Margolis RK (Oct 1992). "Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain". J Biol Chem. 267 (27): 19536–47. PMID 1326557.
"Entrez Gene: NCAN neurocan".
Cichon S, Mühleisen TW, Degenhardt FA, Mattheisen M, Miró X, Strohmaier J, Steffens M, Meesters C, Herms S, Weingarten M, Priebe L, Haenisch B, Alexander M, Vollmer J, Breuer R, Schmäl C, Tessmann P, Moebus S, Wichmann HE, Schreiber S, Müller-Myhsok B, Lucae S, Jamain S, Leboyer M, Bellivier F, Etain B, Henry C, Kahn JP, Heath S, Hamshere M, O'Donovan MC, Owen MJ, Craddock N, Schwarz M, Vedder H, Kammerer-Ciernioch J, Reif A, Sasse J, Bauer M, Hautzinger M, Wright A, Mitchell PB, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Gustafsson O, Andreassen O, Djurovic S, Sigurdsson E, Steinberg S, Stefansson H, Stefansson K, Kapur-Pojskic L, Oruc L, Rivas F, Mayoral F, Chuchalin A, Babadjanova G, Tiganov AS, Pantelejeva G, Abramova LI, Grigoroiu-Serbanescu M, Diaconu CC, Czerski PM, Hauser J, Zimmer A, Lathrop M, Schulze TG, Wienker TF, Schumacher J, Maier W, Propping P, Rietschel M, Nöthen MM (March 2011). "Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder". Am. J. Hum. Genet. 88 (3): 372–81. doi:10.1016/j.ajhg.2011.01.017. PMC 3059436. PMID 21353194.
Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram Ö, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A (September 2012). "Studies in humans and mice implicate neurocan in the etiology of mania". Am J Psychiatry. 169 (9): 982–90. doi:10.1176/appi.ajp.2012.11101585. PMID 22952076.

مشارکت‌کنندگان ویکی‌پدیا. «Neurocan». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۲ دسامبر ۲۰۱۷.

بیشتر بخوانید

Rauch U, Grimpe B, Kulbe G, Arnold-Ammer I, Beier DR, Fässler R (1996). "Structure and chromosomal localization of the mouse neurocan gene". Genomics. 28 (3): 405–10. doi:10.1006/geno.1995.1168. PMID 7490074.
Friedlander DR, Milev P, Karthikeyan L, Margolis RK, Margolis RU, Grumet M (1994). "The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth". J. Cell Biol. 125 (3): 669–80. doi:10.1083/jcb.125.3.669. PMC 2119998. PMID 7513709.
Milev P, Maurel P, Häring M, Margolis RK, Margolis RU (1996). "TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM". J. Biol. Chem. 271 (26): 15716–23. doi:10.1074/jbc.271.26.15716. PMID 8663515.
Retzler C, Göhring W, Rauch U (1996). "Analysis of neurocan structures interacting with the neural cell adhesion molecule N-CAM". J. Biol. Chem. 271 (44): 27304–10. doi:10.1074/jbc.271.44.27304. PMID 8910306.
Rauch U, Clement A, Retzler C, Fröhlich L, Fässler R, Göhring W, Faissner A (1997). "Mapping of a defined neurocan binding site to distinct domains of tenascin-C". J. Biol. Chem. 272 (43): 26905–12. doi:10.1074/jbc.272.43.26905. PMID 9341124.
Milev P, Chiba A, Häring M, Rauvala H, Schachner M, Ranscht B, Margolis RK, Margolis RU (1998). "High affinity binding and overlapping localization of neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta with tenascin-R, amphoterin, and the heparin-binding growth-associated molecule". J. Biol. Chem. 273 (12): 6998–7005. doi:10.1074/jbc.273.12.6998. PMID 9507007.
Prange CK, Pennacchio LA, Lieuallen K, Fan W, Lennon GG (1998). "Characterization of the human neurocan gene, CSPG3". Gene. 221 (2): 199–205. doi:10.1016/S0378-1119(98)00455-7. PMID 9795216.
Oleszewski M, Gutwein P, von der Lieth W, Rauch U, Altevogt P (2000). "Characterization of the L1-neurocan-binding site. Implications for L1-L1 homophilic binding". J. Biol. Chem. 275 (44): 34478–85. doi:10.1074/jbc.M004147200. PMID 10934197.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000002341 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1326557-4] Rauch U, Karthikeyan L, Maurel P, Margolis RU, Margolis RK (Oct 1992). "Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain". J Biol Chem. 267 (27): 19536–47. PMID 1326557.

[entrez-5] "Entrez Gene: NCAN neurocan".

[6] Cichon S, Mühleisen TW, Degenhardt FA, Mattheisen M, Miró X, Strohmaier J, Steffens M, Meesters C, Herms S, Weingarten M, Priebe L, Haenisch B, Alexander M, Vollmer J, Breuer R, Schmäl C, Tessmann P, Moebus S, Wichmann HE, Schreiber S, Müller-Myhsok B, Lucae S, Jamain S, Leboyer M, Bellivier F, Etain B, Henry C, Kahn JP, Heath S, Hamshere M, O'Donovan MC, Owen MJ, Craddock N, Schwarz M, Vedder H, Kammerer-Ciernioch J, Reif A, Sasse J, Bauer M, Hautzinger M, Wright A, Mitchell PB, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Gustafsson O, Andreassen O, Djurovic S, Sigurdsson E, Steinberg S, Stefansson H, Stefansson K, Kapur-Pojskic L, Oruc L, Rivas F, Mayoral F, Chuchalin A, Babadjanova G, Tiganov AS, Pantelejeva G, Abramova LI, Grigoroiu-Serbanescu M, Diaconu CC, Czerski PM, Hauser J, Zimmer A, Lathrop M, Schulze TG, Wienker TF, Schumacher J, Maier W, Propping P, Rietschel M, Nöthen MM (March 2011). "Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder". Am. J. Hum. Genet. 88 (3): 372–81. doi:10.1016/j.ajhg.2011.01.017. PMC 3059436. PMID 21353194.

[7] Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram Ö, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A (September 2012). "Studies in humans and mice implicate neurocan in the etiology of mania". Am J Psychiatry. 169 (9): 982–90. doi:10.1176/appi.ajp.2012.11101585. PMID 22952076.