ساکس ۴

فاکتور رونویسی ساکس ۴ (انگلیسی: Transcription factor SOX-4‎) یک پروتئین است که در انسان توسط ژن «SOX4» کُدگذاری می‌شود.[4][5][6] این پروتئین متعلق به خانواده‌ای از فاکتورهای رونویسی است که در تنظیم رشد و نمو جنین و همچنین تعیین سرنوشت سلول‌ها نقش دارند.

SOX4
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 3U2B
معین‌کننده‌ها
نام‌های دیگر	SOX4, EVI16, SRY-box 4, SRY-box transcription factor 4, CSS10
شناسه‌های بیرونی	OMIM: 184430 MGI: 98366 HomoloGene: 2338 GeneCards: SOX4
Gene location (Mouse) Chr. Chromosome 13 (mouse)[1] Band 13 A3.1|13 12.87 cM Start 28,948,919 bp[1] End 28,953,713 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • DNA binding • GO:0001105 transcription coactivator activity • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000975 transcription cis-regulatory region binding • core promoter sequence-specific DNA binding • GO:0001948 پیوند پروتئینی • protein heterodimerization activity • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding ترکیبات سلولی • سیتوپلاسم • نوکلئوپلاسم • میتوکندری • هسته یاخته فرایند زیستی • skeletal system development • noradrenergic neuron differentiation • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • cardiac ventricle formation • glial cell development • regulation of transcription, DNA-templated • limb bud formation • regulation of protein stability • sympathetic nervous system development • somatic stem cell population maintenance • glucose homeostasis • positive regulation of canonical Wnt signaling pathway • ventricular septum morphogenesis • protein stabilization • ascending aorta morphogenesis • negative regulation of cell death • mitral valve morphogenesis • positive regulation of translation • transcription, DNA-templated • neuroepithelial cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of Wnt signaling pathway • negative regulation of protein ubiquitination • heart development • pro-B cell differentiation • atrial septum primum morphogenesis • T cell differentiation • kidney morphogenesis • positive regulation of cell population proliferation • spinal cord development • positive regulation of apoptotic process • glial cell proliferation • canonical Wnt signaling pathway • positive regulation of N-terminal peptidyl-lysine acetylation • spinal cord motor neuron differentiation • cardiac right ventricle morphogenesis • neural tube formation • cellular response to glucose stimulus • endocrine pancreas development • negative regulation of cell population proliferation • positive regulation of insulin secretion • positive regulation of transcription by RNA polymerase II • DNA damage response, detection of DNA damage • transcription by RNA polymerase II • دگرگونی یاخته‌ Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	6659	20677
آنسامبل	ENSG00000124766	ENSMUSG00000076431
یونی‌پروت	Q06945	Q06831
RefSeq (mRNA)	NM_003107	NM_009238
RefSeq (پروتئین)	NP_003098	NP_033264
موقعیت (UCSC)	n/a	Chr : 28.95 – 28.95 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

پروتئین ساکس ۴ در لنفوسیت‌ها (B و T) بیان می‌شوند و جهت تکامل لنفوسیت‌های B مورد نیازند.[7]

اهمیت بالینی

یک ناحیهٔ ژنومی در مجاورت ژن ساکس ۴ را با بروز سرطان مخاط رحم مرتبط دانسته‌اند.[8][9]

جستارهای وابسته

• پروتئین‌های خانواده ساکس

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000076431 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN (January 1994). "Characterization and mapping of the human SOX4 gene". Mammalian Genome. 4 (10): 577–84. doi:10.1007/BF00361388. PMID 8268656.
5. Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (October 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenetics and Cell Genetics. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625.
6. "Entrez Gene: SOX4 SRY (sex determining region Y)-box 4".
7. Smith E, Sigvardsson M (June 2004). "The roles of transcription factors in B lymphocyte commitment, development, and transformation". Journal of Leukocyte Biology. 75 (6): 973–81. doi:10.1189/jlb.1103554. PMID 14982952.
8. O'Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, et al. (August 2018). "Identification of nine new susceptibility loci for endometrial cancer". Nature Communications. 9 (1): 3166. doi:10.1038/s41467-018-05427-7. PMC 6085317. PMID 30093612.
9. Chen MM, O'Mara TA, Thompson DJ, Painter JN, Attia J, Black A, et al. (June 2016). "GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer". Human Molecular Genetics. 25 (12): 2612–2620. doi:10.1093/hmg/ddw092. PMC 5868213. PMID 27008869.

• مشارکت‌کنندگان ویکی‌پدیا. «SOX4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۰ اوت ۲۰۲۰.

برای مطالعهٔ بیشتر

• Kamachi Y, Uchikawa M, Kondoh H (April 2000). "Pairing SOX off: with partners in the regulation of embryonic development". Trends in Genetics. 16 (4): 182–7. doi:10.1016/S0168-9525(99)01955-1. PMID 10729834.
• Bowles J, Schepers G, Koopman P (November 2000). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators". Developmental Biology. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752.
• Wilson M, Koopman P (August 2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
• Schepers GE, Teasdale RD, Koopman P (August 2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
• Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A (June 1992). "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Research. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMC 336939. PMID 1614875.
• Wotton D, Lake RA, Farr CJ, Owen MJ (March 1995). "The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer". The Journal of Biological Chemistry. 270 (13): 7515–22. doi:10.1074/jbc.270.13.7515. PMID 7706298.
• van de Wetering M, Oosterwegel M, van Norren K, Clevers H (October 1993). "Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes". The EMBO Journal. 12 (10): 3847–54. doi:10.1002/j.1460-2075.1993.tb06063.x. PMC 413668. PMID 8404853.
• van Houte LP, Chuprina VP, van der Wetering M, Boelens R, Kaptein R, Clevers H (December 1995). "Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4". The Journal of Biological Chemistry. 270 (51): 30516–24. doi:10.1074/jbc.270.51.30516. PMID 8530483.
• Ahn SG, Cho GH, Jeong SY, Rhim H, Choi JY, Kim IK (June 1999). "Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells". Biochemical and Biophysical Research Communications. 260 (1): 216–21. doi:10.1006/bbrc.1999.0856. PMID 10381369.
• van Beest M, Dooijes D, van De Wetering M, Kjaerulff S, Bonvin A, Nielsen O, Clevers H (September 2000). "Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs". The Journal of Biological Chemistry. 275 (35): 27266–73. doi:10.1074/jbc.M004102200. PMID 10867006.
• Reppe S, Rian E, Jemtland R, Olstad OK, Gautvik VT, Gautvik KM (December 2000). "Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells". Journal of Bone and Mineral Research. 15 (12): 2402–12. doi:10.1359/jbmr.2000.15.12.2402. PMID 11127205.
• Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ (August 2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science. 293 (5532): 1136–8. doi:10.1126/science.1059157. PMID 11498591.
• Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ (May 2002). "Differential expression of SOX4 and SOX11 in medulloblastoma". Journal of Neuro-Oncology. 57 (3): 201–14. doi:10.1023/A:1015773818302. PMID 12125983.
• Ahn SG, Kim HS, Jeong SW, Kim BE, Rhim H, Shim JY, Kim JW, Lee JH, Kim IK (July 2002). "Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2)". Experimental & Molecular Medicine. 34 (3): 243–9. doi:10.1038/emm.2002.34. PMID 12216117.

پیوند به بیرون

• SOX4 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا