گیرنده پروژسترون

گیرنده پروژسترون (انگلیسی: Progesterone receptor‎) یا به اختصار «PR» که با نامِ «NR3C3» هم شناخته می‌شود، یک گیرندهٔ داخل سلولی است که توسط هورمون استروئیدی پروژسترون فعال می‌شود.

PGR
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 4OAR, 1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU, 5CC0
معین‌کننده‌ها
نام‌های دیگر	PGR, NR3C3, PR, progesterone receptor
شناسه‌های بیرونی	OMIM: 607311 MGI: 97567 HomoloGene: 713 GeneCards: PGR
Gene location (Mouse) Chr. Chromosome 9 (mouse)[1] Band 9|9 A1 Start 8,899,833 bp[1] End 8,968,611 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • DNA binding • sequence-specific DNA binding • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity • ATPase binding • zinc ion binding • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • steroid hormone receptor activity • steroid binding • GO:0001948 پیوند پروتئینی • enzyme binding • signaling receptor binding • lipid binding • GO:0038050، GO:0004886، GO:0038051 nuclear receptor activity • identical protein binding • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ترکیبات سلولی • سیتوپلاسم • membrane • نوکلئوپلاسم • mitochondrial outer membrane • میتوکندری • هسته یاخته • سیتوزول فرایند زیستی • regulation of transcription, DNA-templated • cell-cell signaling • negative regulation of gene expression • transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • ورارسانی پیام • steroid hormone mediated signaling pathway • positive regulation of transcription by RNA polymerase II • ovulation from ovarian follicle • epithelial cell maturation • mammary gland development • پیام‌رسانی پاراکراین • lung alveolus development • regulation of epithelial cell proliferation • progesterone receptor signaling pathway • tertiary branching involved in mammary gland duct morphogenesis Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	5241	18667
آنسامبل	ENSG00000082175	ENSMUSG00000031870
یونی‌پروت	P06401	Q00175
RefSeq (mRNA)	NM_001202474، NM_001271161، NM_001271162، NR_073141، NR_073142، NR_073143، XM_006718858، XM_011542869 NM_000926، NM_001202474، NM_001271161، NM_001271162، NR_073141، NR_073142، NR_073143، XM_006718858، XM_011542869	XM_006509848 NM_008829، XM_006509848
RefSeq (پروتئین)	NP_001189403، NP_001258090، NP_001258091، XP_006718921، XP_011541171 NP_000917، NP_001189403، NP_001258090، NP_001258091، XP_006718921، XP_011541171	XP_006509911 NP_032855، XP_006509911
موقعیت (UCSC)	n/a	Chr : 8.9 – 8.97 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

گیرنده پروژسترون، N-ترمینال
شناسه‌ها
نماد	Progest_rcpt_N
پی‌فم	PF02161
اینترپرو	IPR000128
ساختارهای پروتئینی در دسترس: پی‌فم   structures / ECOD   پی‌دی‌بی RCSB PDB; PDBe; PDBj پی‌دی‌بی‌سام structure summary

این گیرندهٔ پروتئینی در انسان توسط ژن «PGR» که بر روی بازوی بلند کروموزوم ۱۱ قرار دارد، کُد می‌شود[4][5][6] و دو نوع مختلف دارد: «PRA» و «PRB» که وزن ملکولی‌ِشان با یکدیگر متفاوت است.[7][8][9] یک ایزوفرم کمتر شناخته‌شدهٔ سوم به نام «PRC» هم برای این گیرنده شناخته شده‌است.[10]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000031870 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E (March 1987). "Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochemical and Biophysical Research Communications. 143 (2): 740–8. doi:10.1016/0006-291X(87)91416-1. PMID 3551956.
5. Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW (May 1987). "The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2877–81. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240.
6. ensembl.org, Gene: ESR1 (ENSG00000091831)
7. Gadkar-Sable S, Shah C, Rosario G, Sachdeva G, Puri C (2005). "Progesterone receptors: various forms and functions in reproductive tissues". Frontiers in Bioscience. 10: 2118–30. doi:10.2741/1685. PMID 15970482.
8. Kase NG, Speroff L, Glass RL (1999). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 0-683-30379-1.
9. Fritz MA, Speroff L (2005). Clinical gynecologic endocrinology and infertility. Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 0-7817-4795-3.
10. Jacobsen BM, Horwitz KB (2012). "Progesterone receptors, their isoforms and progesterone regulated transcription". Mol. Cell. Endocrinol. 357 (1–2): 18–29. doi:10.1016/j.mce.2011.09.016. PMC 3272316. PMID 21952082.

• مشارکت‌کنندگان ویکی‌پدیا. «Progesterone receptor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۱ نوامبر ۲۰۱۷.

بیشتر بخوانید

• Butnor KJ, Burchette JL, Robboy SJ (July 1999). "Progesterone receptor activity in leiomyomatosis peritonealis disseminata". International Journal of Gynecological Pathology. 18 (3): 259–64. doi:10.1097/00004347-199907000-00012. PMID 12090595.
• Leonhardt SA, Boonyaratanakornkit V, Edwards DP (November 2003). "Progesterone receptor transcription and non-transcription signaling mechanisms". Steroids. 68 (10–13): 761–70. doi:10.1016/S0039-128X(03)00129-6. PMID 14667966.
• Conneely OM, Mulac-Jericevic B, Lydon JP (November 2003). "Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms". Steroids. 68 (10–13): 771–8. doi:10.1016/S0039-128X(03)00126-0. PMID 14667967.
• Bagchi MK, Tsai SY, Tsai MJ, O'Malley BW (April 1992). "Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro". Proceedings of the National Academy of Sciences of the United States of America. 89 (7): 2664–8. doi:10.1073/pnas.89.7.2664. PMC 48722. PMID 1557371.
• Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P (May 1990). "Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B". The EMBO Journal. 9 (5): 1603–14. PMC 551856. PMID 2328727.
• Guiochon-Mantel A, Loosfelt H, Lescop P, Sar S, Atger M, Perrot-Applanat M, Milgrom E (June 1989). "Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers". Cell. 57 (7): 1147–54. doi:10.1016/0092-8674(89)90052-4. PMID 2736623.
• Fernandez MD, Carter GD, Palmer TN (January 1983). "The interaction of canrenone with oestrogen and progesterone receptors in human uterine cytosol". British Journal of Clinical Pharmacology. 15 (1): 95–101. doi:10.1111/j.1365-2125.1983.tb01470.x. PMC 1427833. PMID 6849751.
• Oñate SA, Tsai SY, Tsai MJ, O'Malley BW (November 1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science. 270 (5240): 1354–7. doi:10.1126/science.270.5240.1354. PMID 7481822.
• Zhang Y, Beck CA, Poletti A, Edwards DP, Weigel NL (December 1994). "Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II". The Journal of Biological Chemistry. 269 (49): 31034–40. PMID 7983041.
• Mansour I, Reznikoff-Etievant MF, Netter A (August 1994). "No evidence for the expression of the progesterone receptor on peripheral blood lymphocytes during pregnancy". Human Reproduction. 9 (8): 1546–9. PMID 7989520.
• Kalkhoven E, Wissink S, van der Saag PT, van der Burg B (March 1996). "Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptor". The Journal of Biological Chemistry. 271 (11): 6217–24. doi:10.1074/jbc.271.11.6217. PMID 8626413.
• Wang JD, Zhu JB, Fu Y, Shi WL, Qiao GM, Wang YQ, Chen J, Zhu PD (February 1996). "Progesterone receptor immunoreactivity at the maternofetal interface of first trimester pregnancy: a study of the trophoblast population". Human Reproduction. 11 (2): 413–9. doi:10.1093/humrep/11.2.413. PMID 8671234.
• Thénot S, Henriquet C, Rochefort H, Cavaillès V (May 1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1". The Journal of Biological Chemistry. 272 (18): 12062–8. doi:10.1074/jbc.272.18.12062. PMID 9115274.
• Jenster G, Spencer TE, Burcin MM, Tsai SY, Tsai MJ, O'Malley BW (July 1997). "Steroid receptor induction of gene transcription: a two-step model". Proceedings of the National Academy of Sciences of the United States of America. 94 (15): 7879–84. doi:10.1073/pnas.94.15.7879. PMC 21523. PMID 9223281.
• Shanker YG, Sharma SC, Rao AJ (September 1997). "Expression of progesterone receptor mRNA in the first trimester human placenta". Biochemistry and Molecular Biology International. 42 (6): 1235–40. doi:10.1080/15216549700203701. PMID 9305541.
• Richer JK, Lange CA, Wierman AM, Brooks KM, Tung L, Takimoto GS, Horwitz KB (April 1998). "Progesterone receptor variants found in breast cells repress transcription by wild-type receptors". Breast Cancer Research and Treatment. 48 (3): 231–41. doi:10.1023/A:1005941117247. PMID 9598870.
• Williams SP, Sigler PB (May 1998). "Atomic structure of progesterone complexed with its receptor". Nature. 393 (6683): 392–6. doi:10.1038/30775. PMID 9620806.
• Boonyaratanakornkit V, Melvin V, Prendergast P, Altmann M, Ronfani L, Bianchi ME, Taraseviciene L, Nordeen SK, Allegretto EA, Edwards DP (August 1998). "High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells". Molecular and Cellular Biology. 18 (8): 4471–87. doi:10.1128/mcb.18.8.4471. PMC 109033. PMID 9671457.
• Nawaz Z, Lonard DM, Smith CL, Lev-Lehman E, Tsai SY, Tsai MJ, O'Malley BW (February 1999). "The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily". Molecular and Cellular Biology. 19 (2): 1182–9. doi:10.1128/mcb.19.2.1182. PMC 116047. PMID 9891052.

پیوند به بیرون

• Progesterone Receptors در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا