BCL2L1

پروتئین ۱ شبه Bcl-2 (انگلیسی: BCL2-like 1‎) یک ژن در انسان است. این ژن، از طریق «پیرایش دگرسان»، دو پروتئین «Bcl-xL» و «Bcl-xS» را کُدگذاری می‌کند[4] که اولی فعال‌کنندهٔ آپوپتوز و دومی بازدارندهٔ آپوپتوز است.[4][5]

BCL2L1
ساختارهای موجود PDB Ortholog search: PDBe RCSB List of PDB id codes 1BXL, 1G5J, 1LXL, 1MAZ, 1R2D, 1R2E, 1R2G, 1R2H, 1R2I, 1YSG, 1YSI, 1YSN, 2B48, 2LP8, 2LPC, 2M03, 2M04, 2ME8, 2ME9, 2MEJ, 2O1Y, 2O2M, 2O2N, 2P1L, 2PON, 2YJ1, 2YQ6, 2YQ7, 2YXJ, 3CVA, 3FDL, 3FDM, 3INQ, 3IO8, 3PL7, 3QKD, 3R85, 3SP7, 3SPF, 3WIZ, 3ZK6, 3ZLN, 3ZLO, 3ZLR, 4A1U, 4A1W, 4AQ3, 4BPK, 4C52, 4C5D, 4CIN, 4EHR, 4HNJ, 4IEH, 4PPI, 4QVE, 4QVF, 4QVX, 4TUH, 5AGW, 5AGX, 4Z9V, 5FMK, 5FMJ, 5C3G
معین‌کننده‌ها
نام‌های دیگر	BCL2L1, Bcl2l1, Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, BCL-XL/S, BCLXL, BCLXS, PPP1R52, bcl-xS, BCL2L, BCLX, Bcl-X, bcl-xL, BCL2 like 1
شناسه‌های بیرونی	OMIM: 600039 MGI: 88139 HomoloGene: 7639 GeneCards: BCL2L1
Gene location (Mouse) Chr. Chromosome 2 (mouse)[1] Band 2 75.41 cM|2 H1 Start 152,780,668 bp[1] End 152,831,728 bp[1]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • BH3 domain binding • GO:0001948 پیوند پروتئینی • identical protein binding • protein kinase binding • protein homodimerization activity • protein heterodimerization activity ترکیبات سلولی • سیتوپلاسم • integral component of membrane • سیتوزول • میان‌تن • پوشش هسته‌ای • mitochondrial membrane • membrane • Bcl-2 family protein complex • سیناپس • intracellular anatomical structure • synaptic vesicle membrane • microtubule organizing center • پیوند میان‌یاخته‌ای • mitochondrial matrix • میتوکندری • mitochondrial inner membrane • اسکلت سلولی • GO:0016023 cytoplasmic vesicle • هسته یاخته • شبکه آندوپلاسمی • mitochondrial outer membrane فرایند زیستی • negative regulation of neuron apoptotic process • neuron apoptotic process • germ cell development • negative regulation of execution phase of apoptosis • regulation of apoptotic process • response to cytokine • male gonad development • اندوسیتوز • negative regulation of intrinsic apoptotic signaling pathway • mitotic cell cycle checkpoint signaling • negative regulation of release of cytochrome c from mitochondria • response to virus • negative regulation of apoptotic process • response to cycloheximide • in utero embryonic development • cellular response to alkaloid • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • regulation of mitochondrial membrane potential • regulation of mitochondrial membrane permeability • apoptotic mitochondrial changes • cellular response to gamma radiation • اسپرماتوژنز • positive regulation of cell population proliferation • positive regulation of apoptotic process • cellular response to amino acid stimulus • ovarian follicle development • apoptotic process in bone marrow cell • لقاح • response to radiation • suppression by virus of host apoptotic process • cell population proliferation • mitochondrion morphogenesis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of autophagy • positive regulation of intrinsic apoptotic signaling pathway • negative regulation of anoikis • hepatocyte apoptotic process • release of cytochrome c from mitochondria • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • مرگ برنامه‌ریزی‌شده یاخته • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • growth • negative regulation of protein localization to plasma membrane • cytokine-mediated signaling pathway • regulation of cytokinesis • regulation of growth • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	598	12048
آنسامبل	ENSG00000171552	ENSMUSG00000007659
یونی‌پروت	Q07817 Q5TE64	Q64373
RefSeq (mRNA)	NM_138578، XM_011528964، XR_936599، NM_001317919، NM_001317920، NM_001317921، NR_134257، NM_001322239، NM_001322240، NM_001322242، XM_017027993، XR_001754364 NM_001191، NM_138578، XM_011528964، XR_936599، NM_001317919، NM_001317920، NM_001317921، NR_134257، NM_001322239، NM_001322240، NM_001322242، XM_017027993، XR_001754364	NM_001289717، NM_001289739، NM_009743، XM_006498611، XM_006498612، XM_011239260، XR_374396، NM_001355053، NR_149254، XM_030246899 NM_001289716، NM_001289717، NM_001289739، NM_009743، XM_006498611، XM_006498612، XM_011239260، XR_374396، NM_001355053، NR_149254، XM_030246899
RefSeq (پروتئین)	NP_001304848، NP_001304849، NP_001304850، NP_001309168، NP_001309169، NP_001309171، NP_612815، XP_011527266، XP_016883482 NP_001182، NP_001304848، NP_001304849، NP_001304850، NP_001309168، NP_001309169، NP_001309171، NP_612815، XP_011527266، XP_016883482	NP_001276646، NP_001276668، NP_033873، XP_006498674، XP_006498675، XP_011237562، NP_001341982 NP_001276645، NP_001276646، NP_001276668، NP_033873، XP_006498674، XP_006498675، XP_011237562، NP_001341982
موقعیت (UCSC)	n/a	Chr : 152.78 – 152.83 Mb
جستجوی PubMed	[2]	[3]
ویکی‌داده
مشاهده/ویرایش Human View/Edit Mouse

عملکرد

پروتئین حاصل از این ژن که در غشاء بیرونی میتوکندری جای دارد، به خانواده Bcl-2 تعلق داشته و در تنظیم فرایند آپوپتوز دخالت دارد.

تعامل‌های شیمیایی

این پروتئین با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

• APAF1[6][7]
• PPP1CA[8]
• RAD9A[9][10]
• BIK[9][11][12][13]
• BAK1[9][14][15][16][17]
• BAD[14][11][10][18][8][19][20][21][22][23][24]
• BAX[14][18][25][12]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000007659 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Boise LH, González-García M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nuñez G, Thompson CB (Aug 1993). "bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death" (PDF). Cell. 74 (4): 597–608. doi:10.1016/0092-8674(93)90508-N. hdl:2027.42/30629. PMID 8358789. S2CID 13542617.
5. "Entrez Gene: BCL2L1 BCL2-like 1".
6. Hu Y, Benedict MA, Wu D, Inohara N, Núñez G (Apr 1998). "Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation". Proceedings of the National Academy of Sciences of the United States of America. 95 (8): 4386–91. Bibcode:1998PNAS...95.4386H. doi:10.1073/pnas.95.8.4386. PMC 22498. PMID 9539746.
7. Pan G, O'Rourke K, Dixit VM (Mar 1998). "Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex". The Journal of Biological Chemistry. 273 (10): 5841–5. doi:10.1074/jbc.273.10.5841. PMID 9488720.
8. Ayllón V, Cayla X, García A, Fleischer A, Rebollo A (Jul 2002). "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad". European Journal of Immunology. 32 (7): 1847–55. doi:10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7. PMID 12115603.
9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
10. Komatsu K, Miyashita T, Hang H, Hopkins KM, Zheng W, Cuddeback S, Yamada M, Lieberman HB, Wang HG (Jan 2000). "Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis". Nature Cell Biology. 2 (1): 1–6. doi:10.1038/71316. PMID 10620799. S2CID 52847351.
11. Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (Feb 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Molecular Cell. 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
12. Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT (Jul 2003). "Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway". The EMBO Journal. 22 (14): 3580–90. doi:10.1093/emboj/cdg343. PMC 165613. PMID 12853473.
13. Jiang A, Clark EA (May 2001). "Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis". Journal of Immunology. 166 (10): 6025–33. doi:10.4049/jimmunol.166.10.6025. PMID 11342619.
14. Zhang H, Nimmer P, Rosenberg SH, Ng SC, Joseph M (Aug 2002). "Development of a high-throughput fluorescence polarization assay for Bcl-x(L)". Analytical Biochemistry. 307 (1): 70–5. doi:10.1016/S0003-2697(02)00028-3. PMID 12137781.
15. Whitfield J, Harada K, Bardelle C, Staddon JM (Nov 2003). "High-throughput methods to detect dimerization of Bcl-2 family proteins". Analytical Biochemistry. 322 (2): 170–8. doi:10.1016/j.ab.2003.07.014. PMID 14596824.
16. Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC (Jun 2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins". Genes & Development. 19 (11): 1294–305. doi:10.1101/gad.1304105. PMC 1142553. PMID 15901672.
17. Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J (Feb 2001). "Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL". Nature Cell Biology. 3 (2): 173–82. doi:10.1038/35055085. PMID 11175750. S2CID 32934759.
18. Strobel T, Tai YT, Korsmeyer S, Cannistra SA (Nov 1998). "BAD partly reverses paclitaxel resistance in human ovarian cancer cells". Oncogene. 17 (19): 2419–27. doi:10.1038/sj.onc.1202180. PMID 9824152.
19. Jin Z, Xin M, Deng X (Apr 2005). "Survival function of protein kinase C{iota} as a novel nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-activated bad kinase". The Journal of Biological Chemistry. 280 (16): 16045–52. doi:10.1074/jbc.M413488200. PMID 15705582.
20. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ (Jan 1995). "Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death". Cell. 80 (2): 285–91. doi:10.1016/0092-8674(95)90411-5. PMID 7834748. S2CID 10343291.
21. Petros AM, Nettesheim DG, Wang Y, Olejniczak ET, Meadows RP, Mack J, Swift K, Matayoshi ED, Zhang H, Thompson CB, Fesik SW (Dec 2000). "Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies". Protein Science. 9 (12): 2528–34. doi:10.1110/ps.9.12.2528. PMC 2144516. PMID 11206074.
22. Chattopadhyay A, Chiang CW, Yang E (Jul 2001). "BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest". Oncogene. 20 (33): 4507–18. doi:10.1038/sj.onc.1204584. PMID 11494146.
23. Iwahashi H, Eguchi Y, Yasuhara N, Hanafusa T, Matsuzawa Y, Tsujimoto Y (Nov 1997). "Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy". Nature. 390 (6658): 413–7. Bibcode:1997Natur.390..413I. doi:10.1038/37144. PMID 9389483. S2CID 1936633.
24. Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG (Nov 2000). "PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition". Oncogene. 19 (46): 5291–7. doi:10.1038/sj.onc.1203901. PMID 11077446.
25. Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, Korsmeyer SJ (Aug 1995). "Multiple Bcl-2 family members demonstrate selective dimerizations with Bax". Proceedings of the National Academy of Sciences of the United States of America. 92 (17): 7834–8. Bibcode:1995PNAS...92.7834S. doi:10.1073/pnas.92.17.7834. PMC 41240. PMID 7644501.

• مشارکت‌کنندگان ویکی‌پدیا. «BCL2-like 1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۵ اکتبر ۲۰۲۰.

برای مطالعهٔ بیشتر

• Ogata Y, Takahashi M (Sep 2003). "Bcl-xL as an antiapoptotic molecule for cardiomyocytes". Drug News & Perspectives. 16 (7): 446–52. doi:10.1358/dnp.2003.16.7.829356. PMID 14668940.

پیوند به بیرون

• مکان ژنوم BCL2L1 انسانی و صفحهٔ جزئیات ژنی BCL2L1 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.