CBX5

CBX5
ساختارهای موجود
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FDT, 3I3C
معین‌کننده‌ها
نام‌های دیگر	CBX5, HEL25, HP1, HP1A, chromobox 5
شناسه‌های بیرونی	OMIM: 604478 MGI: 109372 HomoloGene: 7257 GeneCards: CBX5
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[1]
End	103,239,816 bp[1]
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein homodimerization activity; • GO:0001948 پیوند پروتئینی; • protein-macromolecule adaptor activity; • chromatin binding; • histone deacetylase binding; • methylated histone binding; • ribonucleoprotein complex binding; • GO:0032403 protein-containing complex binding; • identical protein binding;
ترکیبات سلولی	• کینه توکور; • هسته یاخته; • nuclear envelope; • pericentric heterochromatin; • هستک; • histone deacetylase complex; • نوکلئوپلاسم; • chromocenter; • heterochromatin; • میان‌پار; • histone methyltransferase complex; • transcription repressor complex; • کروموزوم; • PML body; • protein-containing complex; • ribonucleoprotein complex; • site of DNA damage;
فرایند زیستی	• انعقاد خون; • negative regulation of transcription, DNA-templated; • GO:0022415 viral process; • negative regulation of transcription by RNA polymerase II; • negative regulation of G0 to G1 transition; • cellular response to DNA damage stimulus;
	Sources:آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	23468
	12419
	ENSG00000094916
	ENSMUSG00000009575
	P45973
	Q61686
	NM_001127321، NM_001127322 NM_012117، NM_001127321، NM_001127322
	NM_001110216، NM_007626، XM_006520372، XM_006520374، XM_006520375، XM_006520376، XM_006520377، NM_001358950، XM_030248308 NM_001076789، NM_001110216، NM_007626، XM_006520372، XM_006520374، XM_006520375، XM_006520376، XM_006520377، NM_001358950، XM_030248308
	NP_001120794، NP_036249 NP_001120793، NP_001120794، NP_036249
	NP_001103686، NP_031652، XP_006520435، XP_006520437، XP_006520438، XP_006520439، XP_006520440، NP_001345879، XP_030104168 NP_001070257، NP_001103686، NP_031652، XP_006520435، XP_006520437، XP_006520438، XP_006520439، XP_006520440، NP_001345879، XP_030104168
	ویکی‌داده
مشاهده/ویرایش Human	View/Edit Mouse

هم‌ساخت ۵ پروتئین کروموباکس (انگلیسی: Chromobox protein homolog 5‎) یک پروتئین است که در انسان توسط ژن «CBX5» کُدگذاری می‌شود[4][5] و نوعی پروتئین غیر هستونی و به‌شدت محافظت‌شده‌است.

تعامل‌های مولکولی

این پروتئین با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

منابع

GRCm38: Ensembl release 89: ENSMUSG00000009575 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ye Q, Worman HJ (Jun 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". The Journal of Biological Chemistry. 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349.
"Entrez Gene: CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila)".
Nielsen AL, Oulad-Abdelghani M, Ortiz JA, Remboutsika E, Chambon P, Losson R (Apr 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Molecular Cell. 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. PMID 11336697.
Zhang CL, McKinsey TA, Olson EN (Oct 2002). "Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation". Molecular and Cellular Biology. 22 (20): 7302–12. doi:10.1128/mcb.22.20.7302-7312.2002. PMC 139799. PMID 12242305.

مشارکت‌کنندگان ویکی‌پدیا. «CBX5 (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۵ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

Saunders WS, Chue C, Goebl M, Craig C, Clark RF, Powers JA, Eissenberg JC, Elgin SC, Rothfield NF, Earnshaw WC (Feb 1993). "Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity". Journal of Cell Science. 104 (2): 573–82. PMID 8505380.
Sugimoto K, Yamada T, Muro Y, Himeno M (Jul 1996). "Human homolog of Drosophila heterochromatin-associated protein 1 (HP1) is a DNA-binding protein which possesses a DNA-binding motif with weak similarity to that of human centromere protein C (CENP-C)". Journal of Biochemistry. 120 (1): 153–9. doi:10.1093/oxfordjournals.jbchem.a021378. PMID 8864858.
Ye Q, Callebaut I, Pezhman A, Courvalin JC, Worman HJ (Jun 1997). "Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR". The Journal of Biological Chemistry. 272 (23): 14983–9. doi:10.1074/jbc.272.23.14983. PMID 9169472.
Lessard J, Baban S, Sauvageau G (Feb 1998). "Stage-specific expression of polycomb group genes in human bone marrow cells". Blood. 91 (4): 1216–24. PMID 9454751.
Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC (Dec 1998). "INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1". The Journal of Cell Biology. 143 (7): 1763–74. doi:10.1083/jcb.143.7.1763. PMC 2175214. PMID 9864353.
Minc E, Allory Y, Worman HJ, Courvalin JC, Buendia B (Aug 1999). "Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells". Chromosoma. 108 (4): 220–34. doi:10.1007/s004120050372. PMID 10460410.
Murzina N, Verreault A, Laue E, Stillman B (Oct 1999). "Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins". Molecular Cell. 4 (4): 529–40. doi:10.1016/S1097-2765(00)80204-X. PMID 10549285.
Nielsen AL, Ortiz JA, You J, Oulad-Abdelghani M, Khechumian R, Gansmuller A, Chambon P, Losson R (Nov 1999). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family". The EMBO Journal. 18 (22): 6385–95. doi:10.1093/emboj/18.22.6385. PMC 1171701. PMID 10562550.
Zhao T, Heyduk T, Allis CD, Eissenberg JC (Sep 2000). "Heterochromatin protein 1 binds to nucleosomes and DNA in vitro". The Journal of Biological Chemistry. 275 (36): 28332–8. doi:10.1074/jbc.M003493200. PMID 10882726.
Lechner MS, Begg GE, Speicher DW, Rauscher FJ (Sep 2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential". Molecular and Cellular Biology. 20 (17): 6449–65. doi:10.1128/MCB.20.17.6449-6465.2000. PMC 86120. PMID 10938122.
Song K, Jung Y, Jung D, Lee I (Mar 2001). "Human Ku70 interacts with heterochromatin protein 1alpha". The Journal of Biological Chemistry. 276 (11): 8321–7. doi:10.1074/jbc.M008779200. PMID 11112778.
Lachner M, O'Carroll D, Rea S, Mechtler K, Jenuwein T (Mar 2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins". Nature. 410 (6824): 116–20. doi:10.1038/35065132. PMID 11242053.
Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T (Mar 2001). "Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain". Nature. 410 (6824): 120–4. doi:10.1038/35065138. PMID 11242054.
Nielsen AL, Oulad-Abdelghani M, Ortiz JA, Remboutsika E, Chambon P, Losson R (Apr 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Molecular Cell. 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. PMID 11336697.
Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC (Jun 2001). "INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis". Current Biology. 11 (11): 886–90. doi:10.1016/S0960-9822(01)00238-X. PMID 11516652.
Scholzen T, Endl E, Wohlenberg C, van der Sar S, Cowell IG, Gerdes J, Singh PB (Feb 2002). "The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure". The Journal of Pathology. 196 (2): 135–44. doi:10.1002/path.1016. PMID 11793364.
Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ (Jan 2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes & Development. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
Sugimoto K, Tasaka H, Dotsu M (Dec 2001). "Molecular behavior in living mitotic cells of human centromere heterochromatin protein HPLalpha ectopically expressed as a fusion to red fluorescent protein". Cell Structure and Function. 26 (6): 705–18. doi:10.1247/csf.26.705. PMID 11942629.
Vassallo MF, Tanese N (Apr 2002). "Isoform-specific interaction of HP1 with human TAFII130". Proceedings of the National Academy of Sciences of the United States of America. 99 (9): 5919–24. doi:10.1073/pnas.092025499. PMC 122877. PMID 11959914.

پیوند به بیرون

مکان ژنوم CBX5 انسانی و صفحهٔ جزئیات ژنی CBX5 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000009575 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8663349-4] Ye Q, Worman HJ (Jun 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". The Journal of Biological Chemistry. 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349.

[entrez-5] "Entrez Gene: CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila)".

[pmid11336697-6] Nielsen AL, Oulad-Abdelghani M, Ortiz JA, Remboutsika E, Chambon P, Losson R (Apr 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Molecular Cell. 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. PMID 11336697.

[pmid12242305-7] Zhang CL, McKinsey TA, Olson EN (Oct 2002). "Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation". Molecular and Cellular Biology. 22 (20): 7302–12. doi:10.1128/mcb.22.20.7302-7312.2002. PMC 139799. PMID 12242305.